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    Hnf4g hepatocyte nuclear factor 4, gamma [ Mus musculus (house mouse) ]

    Gene ID: 30942, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Hnf4gprovided by MGI
    Official Full Name
    hepatocyte nuclear factor 4, gammaprovided by MGI
    Primary source
    MGI:MGI:1353604
    See related
    Ensembl:ENSMUSG00000017688 AllianceGenome:MGI:1353604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NR2A2
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Acts upstream of or within positive regulation of transcription, DNA-templated. Predicted to be located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; and nervous system. Orthologous to human HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 18.4), small intestine adult (RPKM 7.7) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 A1; 3 1.82 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (3573090..3724863)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (3508030..3659800)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA lysine 31 (anticodon CTT) Neighboring gene STARR-seq mESC enhancer starr_06769 Neighboring gene RAB3 GTPase activating protein subunit 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06770 Neighboring gene STARR-seq mESC enhancer starr_06771 Neighboring gene STARR-seq mESC enhancer starr_06773 Neighboring gene STARR-seq mESC enhancer starr_06774 Neighboring gene STARR-seq mESC enhancer starr_06775 Neighboring gene STARR-seq mESC enhancer starr_06776 Neighboring gene STARR-seq mESC enhancer starr_06777 Neighboring gene STARR-seq mESC enhancer starr_06779 Neighboring gene STARR-seq mESC enhancer starr_06780 Neighboring gene ribosomal protein S24, pseudogene 2 Neighboring gene POU domain, class 5, transcription factor 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption. Ayari S, et al. J Endocrinol, 2021 Nov 24. PMID 34647524
    2. Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice. Gerdin AK, et al. Biochem Biophys Res Commun, 2006 Oct 20. PMID 16945327
    3. Three-dimensional interactions between enhancers and promoters during intestinal differentiation depend upon HNF4. Chen L, et al. Cell Rep, 2021 Jan 26. PMID 33503426, Free PMC Article
    4. Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage. Baraille F, et al. Diabetes, 2015 Aug. PMID 25829452
    5. Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma. Taraviras S, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786614

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.
      Title: HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription.
    2. Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption.
      Title: Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption.
    3. Genetic inactivation of Hnf4a and its paralog Hnf4g revealed that HNF4 factors are redundantly required for fetal maturation.
      Title: HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.
    4. HNF4A acts redundantly with an intestine-restricted HNF4 paralog, HNF4G, to activate enhancer chromatin and upregulate the majority of transcripts in the differentiated epithelium; cells fail to differentiate on double knockout of both HNF4 paralogs. Furthermore, we show that SMAD4 and HNF4 function via a reinforcing feed-forward loop.
      Title: A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity.
    5. the loss of HNF-4gamma improves glucose homeostasis through a modulation of the enteroendocrine cell lineage.
      Title: Glucose Tolerance Is Improved in Mice Invalidated for the Nuclear Receptor HNF-4γ: A Critical Role for Enteroendocrine Cell Lineage.
    6. HNF4g has a role in energy expenditure, locomotor activity during night time, and higher body weight
      Title: Phenotypic screening of hepatocyte nuclear factor (HNF) 4-gamma receptor knockout mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte nuclear factor 4-gamma
    Names
    HNF-4-gamma
    nuclear receptor subfamily 2 group A member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395870.1 → NP_001382799.1  hepatocyte nuclear factor 4-gamma isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157926, AC170259
      UniProtKB/TrEMBL
      E9QPS1, Q059V1
      Related
      ENSMUSP00000104031.2, ENSMUST00000108394.4
      Conserved Domains (2) summary
      cd06931
      Location:157 → 378
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:66 → 141
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    2. NM_013920.3 → NP_038948.2  hepatocyte nuclear factor 4-gamma isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157764, AC157926, AC170259
      Consensus CDS
      CCDS17226.1
      UniProtKB/Swiss-Prot
      Q9WUU6
      UniProtKB/TrEMBL
      Q059V1
      Related
      ENSMUSP00000104030.3, ENSMUST00000108393.9
      Conserved Domains (2) summary
      cd06931
      Location:103 → 324
      NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
      cd06960
      Location:12 → 87
      NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      3573090..3724863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUU6.2 GenPept UniProtKB/Swiss-Prot:Q9WUU6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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