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    Uso1 USO1 vesicle docking factor [ Mus musculus (house mouse) ]

    Gene ID: 56041, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Uso1provided by MGI
    Official Full Name
    USO1 vesicle docking factorprovided by MGI
    Primary source
    MGI:MGI:1929095
    See related
    Ensembl:ENSMUSG00000029407 AllianceGenome:MGI:1929095
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAP; Vdp; 115kDa
    Summary
    Acts upstream of or within several processes, including regulation of cellular response to insulin stimulus; secretory granule localization; and small GTPase mediated signal transduction. Located in cytosol and perinuclear region of cytoplasm. Is expressed in central nervous system and retina. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 26.6), genital fat pad adult (RPKM 19.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 E2; 5 46.05 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (92285770..92350659)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (92137909..92202800)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene STARR-positive B cell enhancer mm9_chr5:92512687-92512988 Neighboring gene predicted gene, 46933 Neighboring gene STARR-seq mESC enhancer starr_13632 Neighboring gene uncharacterized LOC105246914 Neighboring gene STARR-seq mESC enhancer starr_13633 Neighboring gene STARR-positive B cell enhancer ABC_E11293 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:92612573-92612756 Neighboring gene predicted gene, 25290 Neighboring gene predicted gene, 42113 Neighboring gene cDNA sequence U90926 Neighboring gene predicted gene, 42112

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GM130 and p115 play a key role in the organisation of the early secretory pathway during skeletal muscle differentiation. Giacomello E, et al. J Cell Sci, 2019 Jan 23. PMID 30630895
    2. Golgi disruption and early embryonic lethality in mice lacking USO1. Kim S, et al. PLoS One, 2012. PMID 23185636, Free PMC Article
    3. p115 Interacts with the GLUT4 vesicle protein, IRAP, and plays a critical role in insulin-stimulated GLUT4 translocation. Hosaka T, et al. Mol Biol Cell, 2005 Jun. PMID 15800058, Free PMC Article
    4. FGF signalling regulates bone growth through autophagy. Cinque L, et al. Nature, 2015 Dec 10. PMID 26595272
    5. RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. Lo JC, et al. PLoS Genet, 2012. PMID 23055941, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within secretory granule localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    general vesicular transport factor p115
    Names
    USO1 homolog, vesicle docking protein
    protein USO1 homolog
    transcytosis associated protein p115
    transcytosis-associated protein
    vesicle docking protein, 115 kDa
    vesicle-docking protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417623.1 → NP_001404552.1  general vesicular transport factor p115 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC122438, AC125542

    2. NM_001417624.1 → NP_001404553.1  general vesicular transport factor p115 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC122438, AC125542

    3. NM_001417625.1 → NP_001404554.1  general vesicular transport factor p115 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC122438, AC125542

    4. NM_001417626.1 → NP_001404555.1  general vesicular transport factor p115 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC122438, AC125542

    5. NM_001417627.1 → NP_001404556.1  general vesicular transport factor p115 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC122438, AC125542
      Related
      ENSMUSP00000144592.2, ENSMUST00000202155.2

    6. NM_001417628.1 → NP_001404557.1  general vesicular transport factor p115 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC122438, AC125542

    7. NM_019490.2 → NP_062363.1  general vesicular transport factor p115 isoform 2

      See identical proteins and their annotated locations for NP_062363.1

      Status: VALIDATED

      Source sequence(s)
      AC122438, AC125542
      Consensus CDS
      CCDS39150.1
      UniProtKB/Swiss-Prot
      Q3T9L9, Q3TH58, Q3U1C7, Q3UMW6, Q91WE7, Q99JZ5, Q9Z1Z0
      Related
      ENSMUSP00000031355.7, ENSMUST00000031355.10
      Conserved Domains (3) summary
      cd00020
      Location:19 → 153
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04869
      Location:347 → 628
      Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
      pfam04871
      Location:841 → 934
      Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      92285770..92350659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535141.5 → XP_006535204.1  general vesicular transport factor p115 isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:652 → 906
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04869
      Location:347 → 635
      Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
      pfam18770
      Location:269 → 329
      Arm_vescicular; Armadillo tether-repeat of vescicular transport factor

    2. XM_036165322.1 → XP_036021215.1  general vesicular transport factor p115 isoform X4

      Conserved Domains (3) summary
      COG1196
      Location:487 → 774
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam04869
      Location:182 → 470
      Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
      pfam18770
      Location:105 → 164
      Arm_vescicular; Armadillo tether-repeat of vescicular transport factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1Z0.2 GenPept UniProtKB/Swiss-Prot:Q9Z1Z0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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