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USO1 USO1 vesicle transport factor [ Homo sapiens (human) ]

Gene ID: 8615, updated on 21-Dec-2019

Summary

Official Symbol
USO1provided by HGNC
Official Full Name
USO1 vesicle transport factorprovided by HGNC
Primary source
HGNC:HGNC:30904
See related
Ensembl:ENSG00000138768 MIM:603344
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAP; VDP; P115
Summary
The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in thyroid (RPKM 38.1), testis (RPKM 30.9) and 25 other tissues See more
Orthologs

Genomic context

See USO1 in Genome Data Viewer
Location:
4q21.1
Exon count:
26
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (75724522..75814289)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76649829..76735366)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 6C pseudogene 9 Neighboring gene cyclin dependent kinase like 2 Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene uncharacterized LOC105377284 Neighboring gene RNA, U2 small nuclear 16, pseudogene Neighboring gene uncharacterized LOC105377285 Neighboring gene protein phosphatase with EF-hand domain 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of vesicle transport factor p115 (USO1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII vesicle coating TAS
Traceable Author Statement
more info
 
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
Golgi organization IEA
Inferred from Electronic Annotation
more info
 
Golgi vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 
secretory granule localization IEA
Inferred from Electronic Annotation
more info
 
small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
transcytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle fusion with Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ER to Golgi transport vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ER to Golgi transport vesicle membrane TAS
Traceable Author Statement
more info
 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
Golgi stack IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
transport vesicle TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
general vesicular transport factor p115
Names
USO1 vesicle docking protein homolog
transcytosis associated protein
vesicle docking protein p115

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290049.1NP_001276978.1  general vesicular transport factor p115 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK314289, AL832010, AL833753, AW043712, BC032654, DA107349, HY008203
    Consensus CDS
    CCDS77929.1
    UniProtKB/Swiss-Prot
    O60763
    Related
    ENSP00000264904.7, ENST00000264904.8
    Conserved Domains (5) summary
    cd00020
    Location:1992
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04869
    Location:351639
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam04871
    Location:837947
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam15619
    Location:672876
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl19219
    Location:746877
    DUF342; Protein of unknown function (DUF342)
  2. NM_003715.3NP_003706.2  general vesicular transport factor p115 isoform 2

    See identical proteins and their annotated locations for NP_003706.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the central coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK314289, AL833753, AW043712, BC032654, DA107349, HY008203
    Consensus CDS
    CCDS75144.1
    UniProtKB/Swiss-Prot
    O60763
    UniProtKB/TrEMBL
    A0A024RDG1
    Related
    ENSP00000444850.2, ENST00000514213.6
    Conserved Domains (5) summary
    cd00020
    Location:19153
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04869
    Location:347628
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam04871
    Location:826936
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam15619
    Location:661865
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl19219
    Location:735866
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    75724522..75814289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714397.3XP_006714460.1  general vesicular transport factor p115 isoform X2

    Conserved Domains (5) summary
    cd00020
    Location:1992
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04869
    Location:351632
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam04871
    Location:830940
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam15619
    Location:665869
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl19219
    Location:739870
    DUF342; Protein of unknown function (DUF342)
  2. XM_006714396.4XP_006714459.1  general vesicular transport factor p115 isoform X1

    Conserved Domains (5) summary
    cd00020
    Location:19153
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam04869
    Location:347635
    Uso1_p115_head; Uso1 / p115 like vesicle tethering protein, head region
    pfam04871
    Location:833943
    Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region
    pfam15619
    Location:668872
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl19219
    Location:742873
    DUF342; Protein of unknown function (DUF342)
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