U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    tpp2 tripeptidyl peptidase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 100331669, updated on 27-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tpp2provided by ZNC
    Official Full Name
    tripeptidyl peptidase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-121214-290
    See related
    Ensembl:ENSDARG00000078751 AllianceGenome:ZFIN:ZDB-GENE-121214-290
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch73-244f7.4
    Summary
    Predicted to enable tripeptidyl-peptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be active in cytosol. Is expressed in embryonic structure. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (418866..443739)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (423683..447251)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene protein S Neighboring gene RAS p21 protein activator 3 Neighboring gene protein-lysine methyltransferase METTL21C-like Neighboring gene methyltransferase like 21e Neighboring gene excision repair cross-complementation group 5 Neighboring gene basic leucine zipper nuclear factor 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Yang Y, et al. Mol Cell, 2019 Sep 19. PMID 31399345
    2. Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations. Zhao Y, et al. Environ Sci Technol, 2016 Sep 20. PMID 27618422
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tripeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tripeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tripeptidyl-peptidase 2
    Names
    tripeptidyl peptidase II
    XP_002660367.2
    XP_005168067.1
    XP_005168068.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      418866..443739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005168010.4 → XP_005168067.1  tripeptidyl-peptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BFH5, R4GDQ0
      Related
      ENSDARP00000126605.1, ENSDART00000152173.2
      Conserved Domains (4) summary
      cd04857
      Location:14 → 489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:237 → 500
      Peptidase_S8; Subtilase family
      pfam12580
      Location:778 → 961
      TPPII; Tripeptidyl peptidase II
      pfam12583
      Location:1033 → 1079
      TPPII_N; Tripeptidyl peptidase II N terminal

    2. XM_005168011.4 → XP_005168068.1  tripeptidyl-peptidase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BG24
      Conserved Domains (4) summary
      cd04857
      Location:14 → 489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:237 → 500
      Peptidase_S8; Subtilase family
      pfam12580
      Location:778 → 961
      TPPII; Tripeptidyl peptidase II
      pfam12583
      Location:1032 → 1078
      TPPII_N; Tripeptidyl peptidase II N terminal

    3. XM_002660321.6 → XP_002660367.2  tripeptidyl-peptidase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M1RJV2
      Conserved Domains (4) summary
      cd04857
      Location:14 → 489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam00082
      Location:237 → 500
      Peptidase_S8; Subtilase family
      pfam12580
      Location:778 → 961
      TPPII; Tripeptidyl peptidase II
      pfam12583
      Location:1019 → 1065
      TPPII_N; Tripeptidyl peptidase II N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous