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    PLPP5 phospholipid phosphatase 5 [ Homo sapiens (human) ]

    Gene ID: 84513, updated on 3-Apr-2024

    Summary

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    Official Symbol
    PLPP5provided by HGNC
    Official Full Name
    phospholipid phosphatase 5provided by HGNC
    Primary source
    HGNC:HGNC:25026
    See related
    Ensembl:ENSG00000147535 MIM:610626; AllianceGenome:HGNC:25026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPPL1; HTPAP; PPAPDC1B
    Summary
    Enables diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in prostate (RPKM 24.6), duodenum (RPKM 12.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8p11.23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38263130..38269224, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38540085..38546179, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38120648..38126742, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38032979-38033836 Neighboring gene RNA, U6 small nuclear 323, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38033837-38034694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27245 Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27246 Neighboring gene BAG cochaperone 4 Neighboring gene Sharpr-MPRA regulatory region 4585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19117 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38089405-38089904 Neighboring gene DDHD domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19119 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19120 Neighboring gene NUP98-NSD3 recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27247 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38235530-38236031 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38238312-38238846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38239137-38239927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38242638-38243268 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:38243269-38243898 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38244052-38244553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19125 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38247000-38247501 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38248280-38248781 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38257600-38258101 Neighboring gene uncharacterized LOC102723716 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38261681-38262180 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38262831-38263332 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma. Wu JC, et al. PLoS One, 2014. PMID 24603412, Free PMC Article
    2. Association of specific genotypes in metastatic suppressor HTPAP with tumor metastasis and clinical prognosis in hepatocellular carcinoma. Ren N, et al. Cancer Res, 2011 May 1. PMID 21531764
    3. Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma. Dai C, et al. Cancer Sci, 2011 Mar. PMID 21219541
    4. HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma. Wu X, et al. Oncogene, 2006 Mar 16. PMID 16261160
    5. PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors. Mahmood SF, et al. Am J Pathol, 2013 Nov. PMID 24051013

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. genetic variants at loci -1053 and +64 of the HTPAP promoter affect the expression of HTPAP, which might be a novel determinant and target for HCC prognosis
      Title: Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma.
    2. PPAPDC1B and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines.
      Title: PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.
    3. Findings identify an HTPAP genotype and associated gene expression pattern that favors metastasis progression and that could be used to predict tumor metastasis and prognosis in HCC patients.
      Title: Association of specific genotypes in metastatic suppressor HTPAP with tumor metastasis and clinical prognosis in hepatocellular carcinoma.
    4. HTPAP-1 may be the transcript of HTPAP to exhibit a suppressive role on hepatocellular cancer(HCC) metastasis, and can be a prognostic marker for HCC.
      Title: Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma.
    5. microarray experiments on PPAPDC1B knockdown indicated this gene interfered with cell signaling pathways, including Janus-activated kinase-signal transducer and activator of transcription, mitogen-activated protein kinase, and protein kinase C pathways
      Title: Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.
    6. DPPL1 and DPPL2 represent a novel type of mammalian phosphatidate phosphatase.
      Title: Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.
    7. HTPAP is a novel metastatic suppressor gene for hepatocellular carcinoma
      Title: HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables diacylglycerol diphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phospholipid phosphatase 5
    Names
    diacylglycerol pyrophosphate like 1
    diacylglycerol pyrophosphate phosphatase-like 1
    phosphatidate phosphatase PPAPDC1B
    phosphatidic acid phosphatase type 2 domain containing 1B
    phosphatidic acid phosphatase type 2 domain-containing protein 1B
    testicular secretory protein Li 38
    NP_001096029.1
    NP_001096030.1
    NP_001341381.1
    NP_001341383.1
    NP_001341385.1
    NP_001341386.1
    NP_001341387.1
    NP_001341388.1
    NP_001397849.1
    NP_115872.2
    XP_011542974.1
    XP_011542976.2
    XP_011542977.2
    XP_016869394.2
    XP_024303074.1
    XP_024303075.2
    XP_047278277.1
    XP_047278279.1
    XP_054217329.1
    XP_054217330.1
    XP_054217331.1
    XP_054217332.1
    XP_054217333.1
    XP_054217334.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102559.2 → NP_001096029.1  phospholipid phosphatase 5 isoform 1

      See identical proteins and their annotated locations for NP_001096029.1

      Status: VALIDATED

      Source sequence(s)
      AA761242, AC087362, BC033025, BC106014, DB458595
      Consensus CDS
      CCDS47841.1
      UniProtKB/Swiss-Prot
      C9JKF5, Q3KQX6, Q8NEB5, Q9BY45
      UniProtKB/TrEMBL
      A0A140VK38, H0YCQ3
      Related
      ENSP00000392553.2, ENST00000424479.7
      Conserved Domains (1) summary
      cd03390
      Location:43 → 231
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    2. NM_001102560.2 → NP_001096030.1  phospholipid phosphatase 5 isoform 3

      See identical proteins and their annotated locations for NP_001096030.1

      Status: VALIDATED

      Source sequence(s)
      AC087362, BE856962, DB458595
      Consensus CDS
      CCDS47843.1
      UniProtKB/Swiss-Prot
      Q8NEB5
      Related
      ENSP00000414522.2, ENST00000419686.2
      Conserved Domains (1) summary
      cl00474
      Location:43 → 155
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    3. NM_001354452.2 → NP_001341381.1  phospholipid phosphatase 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087362
      UniProtKB/TrEMBL
      H0YCQ3
      Related
      ENSP00000432122.1, ENST00000524616.5
      Conserved Domains (1) summary
      cd03390
      Location:43 → 213
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    4. NM_001354454.2 → NP_001341383.1  phospholipid phosphatase 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087362
      Conserved Domains (1) summary
      cd03390
      Location:43 → 240
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    5. NM_001354456.2 → NP_001341385.1  phospholipid phosphatase 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC087362
      Conserved Domains (1) summary
      cd03390
      Location:43 → 214
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    6. NM_001354457.2 → NP_001341386.1  phospholipid phosphatase 5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC087362
      Conserved Domains (1) summary
      cl00474
      Location:43 → 94
      PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

    7. NM_001354458.2 → NP_001341387.1  phospholipid phosphatase 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC087362
      Consensus CDS
      CCDS87598.1
      UniProtKB/TrEMBL
      E9PNB1
      Conserved Domains (1) summary
      cd03390
      Location:2 → 99
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    8. NM_001354459.2 → NP_001341388.1  phospholipid phosphatase 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC087362
      Consensus CDS
      CCDS87598.1
      UniProtKB/TrEMBL
      E9PNB1
      Related
      ENSP00000437248.1, ENST00000531823.5
      Conserved Domains (1) summary
      cd03390
      Location:2 → 99
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    9. NM_001410920.1 → NP_001397849.1  phospholipid phosphatase 5 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC087362
      Consensus CDS
      CCDS94281.1
      Related
      ENSP00000434916.1, ENST00000529359.5

    10. NM_032483.4 → NP_115872.2  phospholipid phosphatase 5 isoform 2

      See identical proteins and their annotated locations for NP_115872.2

      Status: VALIDATED

      Source sequence(s)
      AC087362, BC106014, DB458595
      Consensus CDS
      CCDS47842.1
      UniProtKB/Swiss-Prot
      Q8NEB5
      Related
      ENSP00000390622.2, ENST00000422581.6
      Conserved Domains (1) summary
      cd03390
      Location:43 → 211
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    RNA

    1. NR_148893.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087362

    2. NR_148894.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC087362

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      38263130..38269224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447307.2 → XP_024303075.2  phospholipid phosphatase 5 isoform X8

    2. XM_024447306.2 → XP_024303074.1  phospholipid phosphatase 5 isoform X7

      UniProtKB/TrEMBL
      E9PNB1
      Conserved Domains (1) summary
      cd03390
      Location:2 → 99
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    3. XM_047422323.1 → XP_047278279.1  phospholipid phosphatase 5 isoform X6

    4. XM_011544672.3 → XP_011542974.1  phospholipid phosphatase 5 isoform X1

      See identical proteins and their annotated locations for XP_011542974.1

      UniProtKB/TrEMBL
      A8K7V3
      Conserved Domains (1) summary
      cd03390
      Location:1 → 174
      PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

    5. XM_047422321.1 → XP_047278277.1  phospholipid phosphatase 5 isoform X5

    6. XM_011544675.4 → XP_011542977.2  phospholipid phosphatase 5 isoform X4

    7. XM_011544674.3 → XP_011542976.2  phospholipid phosphatase 5 isoform X3

    8. XM_017013905.2 → XP_016869394.2  phospholipid phosphatase 5 isoform X2

    RNA

    1. XR_001745609.3 RNA Sequence

    2. XR_001745608.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      38540085..38546179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361359.1 → XP_054217334.1  phospholipid phosphatase 5 isoform X8

    2. XM_054361358.1 → XP_054217333.1  phospholipid phosphatase 5 isoform X6

    3. XM_054361354.1 → XP_054217329.1  phospholipid phosphatase 5 isoform X1

    4. XM_054361357.1 → XP_054217332.1  phospholipid phosphatase 5 isoform X4

    5. XM_054361356.1 → XP_054217331.1  phospholipid phosphatase 5 isoform X3

    6. XM_054361355.1 → XP_054217330.1  phospholipid phosphatase 5 isoform X2

    RNA

    1. XR_008487886.1 RNA Sequence

    2. XR_008487885.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NEB5.2 GenPept UniProtKB/Swiss-Prot:Q8NEB5

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