U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    LRP8 LDL receptor related protein 8 [ Canis lupus familiaris (dog) ]

    Gene ID: 489584, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LRP8provided by VGNC
    Official Full Name
    LDL receptor related protein 8provided by VGNC
    Primary source
    VGNC:VGNC:42779
    See related
    Ensembl:ENSCAFG00845016444
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (55794174..55873703)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (55671125..55750885)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (56066954..56146662)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (55787220..55866738)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (55677366..55756833)

    Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111095955 Neighboring gene uncharacterized LOC119876303 Neighboring gene phosphate carrier protein, mitochondrial-like Neighboring gene mago homolog, exon junction complex subunit Neighboring gene CXXC motif containing zinc binding protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    low-density lipoprotein receptor-related protein 8; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 8

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051809.1 Reference ROS_Cfam_1.0

      Range
      55794174..55873703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038666202.1 → XP_038522130.1  low-density lipoprotein receptor-related protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KFZ1, A0A8I3P6H4
      Related
      ENSCAFP00845023550.1, ENSCAFT00845030016.1
      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:527 → 569
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:414 → 444
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:590 → 630
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:378 → 412
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_038666205.1 → XP_038522133.1  low-density lipoprotein receptor-related protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0PQ76, A0A8C0QZN5
      Related
      ENSCAFP00845023596.1, ENSCAFT00845030086.1
      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:486 → 528
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:373 → 403
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:549 → 589
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:337 → 371
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_038666206.1 → XP_038522134.1  low-density lipoprotein receptor-related protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A8C0KHX2, A0A8I3P2X7
      Related
      ENSCAFP00845023413.1, ENSCAFT00845029811.1
      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:486 → 528
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:373 → 403
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:549 → 589
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:337 → 371
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    4. XM_038666207.1 → XP_038522135.1  low-density lipoprotein receptor-related protein 8 isoform X6

      UniProtKB/TrEMBL
      A0A8C0KGF5
      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:403 → 445
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:290 → 320
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:466 → 506
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:254 → 288
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    5. XM_038666210.1 → XP_038522138.1  low-density lipoprotein receptor-related protein 8 isoform X9

      UniProtKB/TrEMBL
      A0A8C0PVJ0, A0A8I3RZL2
      Related
      ENSCAFP00845023622.1, ENSCAFT00845030116.1
      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:362 → 404
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:249 → 279
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:425 → 465
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:213 → 247
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    6. XM_038666211.1 → XP_038522139.1  low-density lipoprotein receptor-related protein 8 isoform X10

      UniProtKB/TrEMBL
      A0A8I3P165
      Related
      ENSCAFP00845023475.1, ENSCAFT00845029895.1
      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:362 → 404
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:249 → 279
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:425 → 465
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:213 → 247
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    7. XM_038666203.1 → XP_038522131.1  low-density lipoprotein receptor-related protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PY60
      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:473 → 515
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:360 → 390
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:269 → 304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:536 → 576
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:324 → 358
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    8. XM_038666204.1 → XP_038522132.1  low-density lipoprotein receptor-related protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QZN5
      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:460 → 502
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:347 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:269 → 304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:523 → 563
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:311 → 345
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    9. XM_038666208.1 → XP_038522136.1  low-density lipoprotein receptor-related protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A8I3RZL2
      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:349 → 391
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:236 → 266
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:145 → 180
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:412 → 452
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:200 → 234
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    10. XM_038666209.1 → XP_038522137.1  low-density lipoprotein receptor-related protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A8I3RZL2
      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:336 → 378
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:223 → 253
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:145 → 180
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:399 → 439
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:187 → 221
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049265.1 Alternate UMICH_Zoey_3.1

      Range
      55787220..55866738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038476320.1 → XP_038332248.1  low-density lipoprotein receptor-related protein 8 isoform X1

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:527 → 569
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:414 → 444
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:590 → 630
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:378 → 412
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_038476323.1 → XP_038332251.1  low-density lipoprotein receptor-related protein 8 isoform X4

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:486 → 528
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:373 → 403
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:549 → 589
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:337 → 371
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_038476324.1 → XP_038332252.1  low-density lipoprotein receptor-related protein 8 isoform X5

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:486 → 528
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:373 → 403
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:549 → 589
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:337 → 371
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    4. XM_038476325.1 → XP_038332253.1  low-density lipoprotein receptor-related protein 8 isoform X6

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:403 → 445
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:290 → 320
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:466 → 506
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:254 → 288
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    5. XM_038476328.1 → XP_038332256.1  low-density lipoprotein receptor-related protein 8 isoform X9

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:362 → 404
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:249 → 279
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:425 → 465
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:213 → 247
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    6. XM_038476329.1 → XP_038332257.1  low-density lipoprotein receptor-related protein 8 isoform X10

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:362 → 404
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:249 → 279
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:425 → 465
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:213 → 247
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    7. XM_038476321.1 → XP_038332249.1  low-density lipoprotein receptor-related protein 8 isoform X2

      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:473 → 515
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:360 → 390
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:269 → 304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:536 → 576
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:324 → 358
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    8. XM_038476322.1 → XP_038332250.1  low-density lipoprotein receptor-related protein 8 isoform X3

      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:460 → 502
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:347 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:269 → 304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:523 → 563
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:311 → 345
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    9. XM_038476326.1 → XP_038332254.1  low-density lipoprotein receptor-related protein 8 isoform X7

      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:349 → 391
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:236 → 266
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:145 → 180
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:412 → 452
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:200 → 234
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    10. XM_038476327.1 → XP_038332255.1  low-density lipoprotein receptor-related protein 8 isoform X8

      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:336 → 378
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:223 → 253
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:145 → 180
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:399 → 439
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:187 → 221
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

      Range
      55677366..55756833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038601634.1 → XP_038457562.1  low-density lipoprotein receptor-related protein 8 isoform X1

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:527 → 569
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:414 → 444
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:590 → 630
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:378 → 412
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_038601637.1 → XP_038457565.1  low-density lipoprotein receptor-related protein 8 isoform X4

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:486 → 528
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:373 → 403
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:549 → 589
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:337 → 371
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_038601638.1 → XP_038457566.1  low-density lipoprotein receptor-related protein 8 isoform X5

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:486 → 528
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:373 → 403
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:295 → 330
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:549 → 589
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:337 → 371
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    4. XM_038601639.1 → XP_038457567.1  low-density lipoprotein receptor-related protein 8 isoform X6

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:403 → 445
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:290 → 320
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:466 → 506
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:254 → 288
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    5. XM_038601642.1 → XP_038457570.1  low-density lipoprotein receptor-related protein 8 isoform X9

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:362 → 404
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:249 → 279
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:425 → 465
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:213 → 247
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    6. XM_038601643.1 → XP_038457571.1  low-density lipoprotein receptor-related protein 8 isoform X10

      Conserved Domains (7) summary
      smart00192
      Location:87 → 119
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:362 → 404
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:249 → 279
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:49 → 83
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:171 → 206
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:425 → 465
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:213 → 247
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    7. XM_038601635.1 → XP_038457563.1  low-density lipoprotein receptor-related protein 8 isoform X2

      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:473 → 515
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:360 → 390
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:269 → 304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:536 → 576
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:324 → 358
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    8. XM_038601636.1 → XP_038457564.1  low-density lipoprotein receptor-related protein 8 isoform X3

      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:460 → 502
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:347 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:269 → 304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:523 → 563
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:311 → 345
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    9. XM_038601640.1 → XP_038457568.1  low-density lipoprotein receptor-related protein 8 isoform X7

      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:349 → 391
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:236 → 266
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:145 → 180
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:412 → 452
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:200 → 234
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    10. XM_038601641.1 → XP_038457569.1  low-density lipoprotein receptor-related protein 8 isoform X8

      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:336 → 378
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:223 → 253
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:145 → 180
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:399 → 439
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:187 → 221
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

      Range
      56066954..56146662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038537492.1 → XP_038393420.1  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0QZN5

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      55671125..55750885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014113774.3 → XP_013969249.2  low-density lipoprotein receptor-related protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8C0KFZ1
      Conserved Domains (7) summary
      smart00192
      Location:89 → 121
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:529 → 571
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:416 → 446
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:51 → 85
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:297 → 332
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:592 → 632
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:380 → 414
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_546704.7 → XP_546704.4  low-density lipoprotein receptor-related protein 8 isoform X4

      UniProtKB/TrEMBL
      A0A8C0QZN5
      Conserved Domains (7) summary
      smart00192
      Location:89 → 121
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:488 → 530
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:375 → 405
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:51 → 85
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:297 → 332
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:551 → 591
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:339 → 373
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_003434660.5 → XP_003434708.2  low-density lipoprotein receptor-related protein 8 isoform X5

      UniProtKB/TrEMBL
      A0A8C0KHX2
      Conserved Domains (7) summary
      smart00192
      Location:89 → 121
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:488 → 530
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:375 → 405
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:51 → 85
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:297 → 332
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:551 → 591
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:339 → 373
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    4. XM_014113777.3 → XP_013969252.2  low-density lipoprotein receptor-related protein 8 isoform X6

      UniProtKB/TrEMBL
      A0A8C0KGF5
      Conserved Domains (7) summary
      smart00192
      Location:89 → 121
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:405 → 447
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:292 → 322
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:51 → 85
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:173 → 208
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:468 → 508
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:256 → 290
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    5. XM_014113778.3 → XP_013969253.2  low-density lipoprotein receptor-related protein 8 isoform X9

      UniProtKB/TrEMBL
      A0A8C0M831, A0A8P0T7I8
      Conserved Domains (7) summary
      smart00192
      Location:89 → 121
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:364 → 406
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:251 → 281
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:51 → 85
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:173 → 208
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:427 → 467
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:215 → 249
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    6. XM_014113779.3 → XP_013969254.2  low-density lipoprotein receptor-related protein 8 isoform X10

      UniProtKB/TrEMBL
      A0A8I3P165
      Conserved Domains (7) summary
      smart00192
      Location:89 → 121
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:364 → 406
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:251 → 281
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:51 → 85
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:173 → 208
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:427 → 467
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:215 → 249
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    7. XM_022418858.2 → XP_022274566.1  low-density lipoprotein receptor-related protein 8 isoform X2

      UniProtKB/TrEMBL
      A0A8C0PY60
      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:473 → 515
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:360 → 390
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:269 → 304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:536 → 576
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:324 → 358
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    8. XM_022418859.2 → XP_022274567.1  low-density lipoprotein receptor-related protein 8 isoform X3

      UniProtKB/TrEMBL
      A0A8C0QZN5
      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:460 → 502
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:347 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:269 → 304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:523 → 563
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:311 → 345
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    9. XM_038521092.1 → XP_038377020.1  low-density lipoprotein receptor-related protein 8 isoform X7

      UniProtKB/TrEMBL
      A0A8C0KGF5
      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:349 → 391
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:236 → 266
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:145 → 180
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:412 → 452
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:200 → 234
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    10. XM_022418860.2 → XP_022274568.1  low-density lipoprotein receptor-related protein 8 isoform X8

      UniProtKB/TrEMBL
      A0A8I3RZL2
      Conserved Domains (7) summary
      smart00192
      Location:61 → 93
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:336 → 378
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:223 → 253
      EGF_CA; Calcium-binding EGF-like domain
      cd00112
      Location:103 → 139
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:145 → 180
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:399 → 439
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:187 → 221
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous