Lrp8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrp8provided by MGI
Official Full Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptorprovided by MGI
Primary source: MGI:MGI:1340044
See related: Ensembl:ENSMUSG00000028613 AllianceGenome:MGI:1340044
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lr8b; ApoER2; 4932703M08Rik
Summary: Enables several functions, including amyloid-beta binding activity; apolipoprotein binding activity; and reelin receptor activity. Involved in several processes, including nervous system development; positive regulation of CREB transcription factor activity; and regulation of dendrite development. Acts upstream of or within central nervous system development and positive regulation of protein kinase activity. Located in cell surface and extracellular space. Is expressed in nervous system and retina layer. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; dementia; myocardial infarction; and schizophrenia. Orthologous to human LRP8 (LDL receptor related protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 24.6), whole brain E14.5 (RPKM 23.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 C7

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (107659337..107734037)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (107802200..107876840)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VLDLR and ApoER2 are receptors for multiple alphaviruses.
Title: VLDLR and ApoER2 are receptors for multiple alphaviruses.
Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns.
Title: Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns.
Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis.
Title: Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis.
Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome.
Title: Protein Phosphatase 2A Activation Via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome.
Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice.
Title: Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice.
The data of the present study demonstrated that the PCSK9 shRNAmediated antiapoptotic effect induced by MCAO in hyperlipidemic mice is associated with ApoER2 downregulation, which may be a potential new therapy for stroke treatment in patients with hyperlipidemia.
Title: Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates neuronal apoptosis following focal cerebral ischemia via apolipoprotein E receptor 2 downregulation in hyperlipidemic mice.
Stage-specific labeling of newborn Apoer2-deficient neurons revealed that the neurons ectopically invaded the marginal zone and that neuronal migration of both early- and late-born neurons was disrupted in the intermediate zone in the Apoer2 KO mice. Rescue experiments showed that ApoER2 functions both in cell-autonomous and noncell-autonomous manners.
Title: ApoER2 Controls Not Only Neuronal Migration in the Intermediate Zone But Also Termination of Migration in the Developing Cerebral Cortex.
GRIP1 binds to apoER2 and EphrinB2 to induce activity-dependent AMPA receptor insertion at the synapse.
Title: GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse.
A1-A1, which is a soluble analog of ApoER2 that binds pathological beta2GPI/anti-beta2GPI complexes, has a positive impact on hemodynamics in lupus-prone mice with spontaneous anti-beta2GPI antibodies and hypertension
Title: Soluble analog of ApoER2 targeting beta2-glycoprotein I in immune complexes counteracts hypertension in lupus-prone mice with spontaneous antiphospholipid syndrome.
findings indicate that impaired processing or localization of apoER2 may contribute to the pathogenic effects of familial Alzheimer's disease mutations in PS1
Title: Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Lrp8 gene: The Lrp8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 337 organisms have orthologs with human gene Lrp8
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	IPI Inferred from Physical Interaction more info	PubMed
enables apolipoprotein binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables high-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables reelin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables very-low-density lipoprotein particle receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ammon gyrus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hippocampus development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within layer formation in cerebral cortex	IGI Inferred from Genetic Interaction more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CREB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of dendrite development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reelin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral spinal cord development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in ventral spinal cord development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in caveola	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: low-density lipoprotein receptor-related protein 8

Names: apolipoprotein E receptor 2; low density lipoprotein receptor relative, 8 ligand binding repeats, brain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080926.1 → NP_001074395.1 low-density lipoprotein receptor-related protein 8 isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes isoform b.

Source sequence(s)

AL611936, AL807828, CJ129380

Consensus CDS

CCDS51255.1

UniProtKB/TrEMBL

B1AXJ3, F6YZZ8

Related

ENSMUSP00000102342.4, ENSMUST00000106731.4

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:397 → 438

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:283 → 313

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:459 → 499

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:247 → 281

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:203 → 239

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
NM_001369051.1 → NP_001355980.1 low-density lipoprotein receptor-related protein 8 isoform c precursor

Status: VALIDATED

Source sequence(s)

AL611936, AL807828

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:368 → 409

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:254 → 284

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:430 → 470

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:218 → 252

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001369052.1 → NP_001355981.1 low-density lipoprotein receptor-related protein 8 isoform d

Status: VALIDATED

Source sequence(s)

AL611936, AL807828

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001369053.1 → NP_001355982.1 low-density lipoprotein receptor-related protein 8 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (6), as well as variant 7, encodes isoform e.

Source sequence(s)

AL611936, AL807828

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_001369054.1 → NP_001355983.1 low-density lipoprotein receptor-related protein 8 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (7), as well as variant 6, encodes isoform e.

Source sequence(s)

AL611936, AL807828

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_053073.3 → NP_444303.2 low-density lipoprotein receptor-related protein 8 isoform a precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AL611936, AL807828, CJ129380, D85463

UniProtKB/Swiss-Prot

Q921B6

Related

ENSMUSP00000158644.2, ENSMUST00000238569.2

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:523 → 564

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:409 → 439

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:585 → 625

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam00057
Location:329 → 365

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam14670
Location:373 → 407

FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

NR_033496.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) includes an alternate internal exon and an alternate splice site in the central region, and lacks a segment in the 3' region, compared to variant 2. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL611936, AL807828, CJ129380

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

107659337..107734037

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011240464.4 → XP_011238766.1 low-density lipoprotein receptor-related protein 8 isoform X16

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:409 → 450

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:295 → 325

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:471 → 511

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:259 → 293

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:202 → 238

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_036163760.1 → XP_036019653.1 low-density lipoprotein receptor-related protein 8 isoform X23

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:409 → 450

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:295 → 325

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:202 → 238

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:471 → 511

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:259 → 293

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030253278.2 → XP_030109138.1 low-density lipoprotein receptor-related protein 8 isoform X17

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:396 → 437

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:282 → 312

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:458 → 498

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:246 → 280

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:202 → 238

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_036163762.1 → XP_036019655.1 low-density lipoprotein receptor-related protein 8 isoform X25

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:396 → 437

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:282 → 312

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:202 → 238

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:458 → 498

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:246 → 280

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240465.4 → XP_011238767.1 low-density lipoprotein receptor-related protein 8 isoform X19

Related

ENSMUSP00000102343.4, ENSMUST00000106732.10

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:368 → 409

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:254 → 284

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:430 → 470

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:218 → 252

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240466.4 → XP_011238768.1 low-density lipoprotein receptor-related protein 8 isoform X21

UniProtKB/TrEMBL

A0A571BE60

Related

ENSMUSP00000158610.2, ENSMUST00000238584.2

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:355 → 396

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:241 → 271

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:417 → 457

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:205 → 239

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240467.4 → XP_011238769.1 low-density lipoprotein receptor-related protein 8 isoform X28

Related

ENSMUSP00000158650.2, ENSMUST00000238651.2

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:355 → 396

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:241 → 271

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:417 → 457

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:205 → 239

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240454.4 → XP_011238756.1 low-density lipoprotein receptor-related protein 8 isoform X1

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:537 → 578

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:423 → 453

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:599 → 639

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:387 → 421

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:330 → 366

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_011240461.4 → XP_011238763.1 low-density lipoprotein receptor-related protein 8 isoform X8

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:537 → 578

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:423 → 453

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:599 → 639

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:387 → 421

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:330 → 366

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_011240456.4 → XP_011238758.1 low-density lipoprotein receptor-related protein 8 isoform X3

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:524 → 565

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:410 → 440

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:586 → 626

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:374 → 408

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:330 → 366

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_017320003.3 → XP_017175492.1 low-density lipoprotein receptor-related protein 8 isoform X9

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:524 → 565

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:410 → 440

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:586 → 626

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:374 → 408

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:330 → 366

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_011240458.4 → XP_011238760.1 low-density lipoprotein receptor-related protein 8 isoform X4

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:496 → 537

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:382 → 412

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:558 → 598

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:346 → 380

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163754.1 → XP_036019647.1 low-density lipoprotein receptor-related protein 8 isoform X11

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:496 → 537

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:382 → 412

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:558 → 598

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:346 → 380

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240459.4 → XP_011238761.1 low-density lipoprotein receptor-related protein 8 isoform X6

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:483 → 524

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:369 → 399

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:545 → 585

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:333 → 367

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163756.1 → XP_036019649.1 low-density lipoprotein receptor-related protein 8 isoform X13

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:483 → 524

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:369 → 399

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:545 → 585

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:333 → 367

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240455.4 → XP_011238757.1 low-density lipoprotein receptor-related protein 8 isoform X2

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:536 → 577

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:422 → 452

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:598 → 638

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:386 → 420

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:329 → 365

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_036163753.1 → XP_036019646.1 low-density lipoprotein receptor-related protein 8 isoform X10

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:523 → 564

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:409 → 439

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:329 → 365

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:585 → 625

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:373 → 407

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030253277.2 → XP_030109137.1 low-density lipoprotein receptor-related protein 8 isoform X5

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:495 → 536

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:381 → 411

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:557 → 597

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:345 → 379

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163755.1 → XP_036019648.1 low-density lipoprotein receptor-related protein 8 isoform X12

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:495 → 536

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:381 → 411

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:557 → 597

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:345 → 379

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240460.4 → XP_011238762.1 low-density lipoprotein receptor-related protein 8 isoform X7

UniProtKB/TrEMBL

B1AXJ4

Related

ENSMUSP00000030356.4, ENSMUST00000030356.10

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:482 → 523

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:368 → 398

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:544 → 584

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:332 → 366

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240462.4 → XP_011238764.1 low-density lipoprotein receptor-related protein 8 isoform X14

UniProtKB/TrEMBL

B1AXJ5

Related

ENSMUSP00000102344.3, ENSMUST00000106733.10

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:482 → 523

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:368 → 398

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:544 → 584

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:332 → 366

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_011240463.4 → XP_011238765.1 low-density lipoprotein receptor-related protein 8 isoform X15

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:410 → 451

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:296 → 326

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:472 → 512

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:260 → 294

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00104
Location:203 → 239

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
XM_036163759.1 → XP_036019652.1 low-density lipoprotein receptor-related protein 8 isoform X22

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:410 → 451

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:296 → 326

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:203 → 239

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:472 → 512

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:260 → 294

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163761.1 → XP_036019654.1 low-density lipoprotein receptor-related protein 8 isoform X24

Conserved Domains (7) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:397 → 438

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:283 → 313

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00057
Location:203 → 239

Ldl_recept_a; Low-density lipoprotein receptor domain class A

pfam00058
Location:459 → 499

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:247 → 281

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163757.1 → XP_036019650.1 low-density lipoprotein receptor-related protein 8 isoform X18

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:369 → 410

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:255 → 285

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:431 → 471

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:219 → 253

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163763.1 → XP_036019656.1 low-density lipoprotein receptor-related protein 8 isoform X26

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:369 → 410

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:255 → 285

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:431 → 471

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:219 → 253

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163758.1 → XP_036019651.1 low-density lipoprotein receptor-related protein 8 isoform X20

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:356 → 397

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:242 → 272

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:418 → 458

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:206 → 240

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163764.1 → XP_036019657.1 low-density lipoprotein receptor-related protein 8 isoform X27

Conserved Domains (6) summary

smart00192
Location:79 → 111

LDLa; Low-density lipoprotein receptor domain class A

smart00135
Location:356 → 397

LY; Low-density lipoprotein-receptor YWTD domain

smart00179
Location:242 → 272

EGF_CA; Calcium-binding EGF-like domain

cd00112
Location:41 → 75

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00058
Location:418 → 458

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:206 → 240

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163766.1 → XP_036019659.1 low-density lipoprotein receptor-related protein 8 isoform X29

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030253283.2 → XP_030109143.1 low-density lipoprotein receptor-related protein 8 isoform X29

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030253279.2 → XP_030109139.1 low-density lipoprotein receptor-related protein 8 isoform X29

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030253281.2 → XP_030109141.1 low-density lipoprotein receptor-related protein 8 isoform X29

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163770.1 → XP_036019663.1 low-density lipoprotein receptor-related protein 8 isoform X30

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163767.1 → XP_036019660.1 low-density lipoprotein receptor-related protein 8 isoform X29

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163771.1 → XP_036019664.1 low-density lipoprotein receptor-related protein 8 isoform X30

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163768.1 → XP_036019661.1 low-density lipoprotein receptor-related protein 8 isoform X30

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030253282.2 → XP_030109142.1 low-density lipoprotein receptor-related protein 8 isoform X29

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163769.1 → XP_036019662.1 low-density lipoprotein receptor-related protein 8 isoform X30

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_036163765.1 → XP_036019658.1 low-density lipoprotein receptor-related protein 8 isoform X29

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_030253284.1 → XP_030109144.1 low-density lipoprotein receptor-related protein 8 isoform X29

Conserved Domains (3) summary

smart00135
Location:84 → 125

LY; Low-density lipoprotein-receptor YWTD domain

pfam00058
Location:146 → 186

Ldl_recept_b; Low-density lipoprotein receptor repeat class B

pfam14670
Location:291 → 328

FXa_inhibition; Coagulation Factor Xa inhibitory site