PDGFD platelet derived growth factor D [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: PDGFDprovided by VGNC
Official Full Name: platelet derived growth factor Dprovided by VGNC
Primary source: VGNC:VGNC:44371
See related: Ensembl:ENSCAFG00845000627
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	5	NC_051809.1 (27910756..28139449)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	5	NC_006587.4 (27797064..28031427)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	5	NC_049226.1 (28005540..28233502)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	5	NC_049265.1 (27944599..28172420)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	5	NC_049746.1 (27831224..28058908)

Chromosome 5 - NC_051809.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables platelet-derived growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein autophosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: platelet-derived growth factor D

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051809.1 Reference ROS_Cfam_1.0

Range

27910756..28139449

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038665083.1 → XP_038521011.1 platelet-derived growth factor D isoform X2

UniProtKB/TrEMBL

A0A8C0K877, A0A8C0RGV9, A0A8C0SPQ7, A0A8I3MGR1

Related

ENSCAFP00845000777.1, ENSCAFT00845001026.1

Conserved Domains (2) summary

cd00041
Location:53 → 163

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:264 → 359

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
XM_038665082.1 → XP_038521010.1 platelet-derived growth factor D isoform X1

UniProtKB/TrEMBL

A0A8C0K877, A0A8C0RGV9

Related

ENSCAFP00845000783.1, ENSCAFT00845001033.1

Conserved Domains (2) summary

cd00041
Location:59 → 169

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:270 → 365

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

Alternate UMICH_Zoey_3.1

Genomic

NC_049265.1 Alternate UMICH_Zoey_3.1

Range

27944599..28172420

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038475199.1 → XP_038331127.1 platelet-derived growth factor D isoform X2

Conserved Domains (2) summary

cd00041
Location:53 → 163

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:264 → 359

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
XM_038475198.1 → XP_038331126.1 platelet-derived growth factor D isoform X1

Conserved Domains (2) summary

cd00041
Location:59 → 169

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:270 → 365

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049746.1 Alternate UNSW_CanFamBas_1.0

Range

27831224..28058908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038600546.1 → XP_038456474.1 platelet-derived growth factor D isoform X2

Conserved Domains (2) summary

cd00041
Location:53 → 163

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:264 → 359

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
XM_038600545.1 → XP_038456473.1 platelet-derived growth factor D isoform X1

Conserved Domains (2) summary

cd00041
Location:59 → 169

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:270 → 365

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049226.1 Alternate UU_Cfam_GSD_1.0

Range

28005540..28233502

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038536340.1 → XP_038392268.1 platelet-derived growth factor D isoform X2

UniProtKB/TrEMBL

A0A8C0K877, A0A8C0RGV9, A0A8C0SPQ7, A0A8I3MGR1

Conserved Domains (2) summary

cd00041
Location:53 → 163

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:264 → 359

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
XM_038536339.1 → XP_038392267.1 platelet-derived growth factor D isoform X1

UniProtKB/TrEMBL

A0A8C0K877, A0A8C0RGV9

Conserved Domains (2) summary

cd00041
Location:59 → 169

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:270 → 365

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

27797064..28031427

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005619855.3 → XP_005619912.1 platelet-derived growth factor D isoform X2

UniProtKB/TrEMBL

A0A8C0K877, A0A8C0RGV9, A0A8C0SPQ7, A0A8I3MGR1

Conserved Domains (2) summary

cd00041
Location:53 → 163

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:264 → 359

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
XM_022418380.2 → XP_022274088.1 platelet-derived growth factor D isoform X1

UniProtKB/TrEMBL

A0A8C0K877, A0A8C0RGV9

Conserved Domains (2) summary

cd00041
Location:59 → 169

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00135
Location:270 → 365

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...