1SPP,1SFP,1SPP


Conserved Protein Domain Family
CUB
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cd00041: CUB 
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CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
Links
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Statistics
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PSSM-Id: 238001
Aligned: 294 rows
Threshold Bit Score: 47.4071
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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heterodimeriz..
Conserved site includes 10 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimerization interface [polypeptide binding site]
Evidence:
  • Structure:1SPP
    - View structure with Cn3D
  • Citation:PMID 9417941
  • Comment:annotation includes both PSPI/PSPII interaction residues highlighted
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    # # #                             #    #                          
1SPP_B       9 CGRVIKDt------SGSISNTDRQk-------nLCTWTILMKpd-qKVRMAIPYLNLa-----CgkEYVEVFDGlls--- 66   pig
O75882     132 CGGRFRLtg----sSGFVTDGPGNyky----ktKCTWLIEGQpn-rIMRLRFNHFATe-----CswDHLYVYDGd----- 192  human
T30337     311 CSSKGRTit---gkNGTVRYPLSGnys---insVCRWMLAVQka-kTIEIRFLQLDIedh-atCtfDYLSFTVNe----- 377  African clawed frog
P97435     270 CDGRFLLtg----dSGVFQADRYPrpde--sgvVCRWIIRVNqg-lSIRMNFGSFIP------HytDVLDIYEGigp--- 333  house mouse
1352368    240 CDGRFLLtg----sSGSFEALHYPkpsn-ntsaVCRWIIRVNqg-lSIQLNFDYFNT------YyaDVLNIYEGmg---- 303  Bos taurus
AAF37867   193 CNSLHTIfg----sHGEFGTVGPAygn----feECSWKIEVPng-kRVRLHFKRFHLennnkyCpyDKLKIYDGssa--- 260  tube worm
AAF37867   309 CSVVNELtgp-sgtFGTTGSQYENn-------eVCSWKIEVAqn-kRVLLHIYRFNIeve-anCeyDSLTVYKGpnd--- 375  tube worm
2497611     94 CFGRIRIs-----dNASYISDGPLdys---psaKCTWLIEPEnsatPLKIRINSFFTe-----CgwDYLYIYDGd----- 155  Caenorhabditis e...
NP_075369  193 CNLTLEDf------YGVFSSPGYShlasvshpqSCLWLLDPHdg-rRLAVRFTALDLs-----Yg-DAVHVYDGagpp-- 257  house mouse
AAF52597  1285 CESRGILtnigksaIGSYQSYRSPwgas-levkECLWILQPKtlqaEKSLLQLEFQWqslamdCdeNAVYIYDSlpdltg 1363 fruit fly

Feature 1                                        #                         # # ##
1SPP_B      67 ----gpSYGKL----CAGAa-------------IVFLSTa-nTMTIKYNRIsgn-ssSPFLIYFYG 109  pig
O75882     193 -----sIYAPL----VAAFsglivperdgnetvPEVVATs-gYALLHFFSDaay-nlTGFNITYSF 247  human
T30337     378 -----kMIRKV----CGSTi------------pSPLIVRs-nKVTVTFFSDgtf-tgRGFEIQFLA 420  African clawed frog
P97435     334 ---skiLRGSF----WETDp-------------GTIRIFs-nLVTVTFLIKsdeydyIGFNATYST 378  house mouse
1352368    304 ----ssKILRAs---LWSNnp-----------gIIRIFSn--QVTATFLIQsdesdyIGFKVTYTA 349  Bos taurus
AAF37867   261 ---sasLKGTL----CGKRr------------pKDIESTg-kTMFVTFSSDisl-tfPGFRIQYSV 305  tube worm
AAF37867   376 ---sapMLGKY----CGETi------------pTFMVSSg-nTMFIKFQTDgsa-rkPGFWIGYTT 420  tube worm
2497611    156 -----sVYGKQlaalCGEQp------------sQEFTAAs-gKALVHFFSDlai-nlNGFNVSYES 202  Caenorhabditis elegans
NP_075369  258 --etprLLRSL----THFSng----------kaVTVETLs-gQAVVSYHTVaws-sgRGFNATYHV 305  house mouse
AAF52597  1364 atqqnqLLAVV----CAPYs------------sPRIIEArssHVTVHYKQGser-rhFGFNALYSV 1412 fruit fly

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