Pmvk phosphomevalonate kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pmvkprovided by RGD
Official Full Name: phosphomevalonate kinaseprovided by RGD
Primary source: RGD:1310812
See related: Ensembl:ENSRNOG00000020696 AllianceGenome:RGD:1310812
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phosphomevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytosol and peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human PMVK (phosphomevalonate kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 216.0), Brain (RPKM 151.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177174344..177184076)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (174876586..174886365)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (188784329..188793890)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables phosphomevalonate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphomevalonate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphomevalonate kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cholesterol biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IEA Inferred from Electronic Annotation more info
involved_in response to cholesterol	ISO Inferred from Sequence Orthology more info
involved_in sterol biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
NOT located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphomevalonate kinase

NP_001008353.1

EC 2.7.4.2

XP_017446383.1

EC 2.7.4.2

XP_038958269.1

EC 2.7.4.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008352.1 → NP_001008353.1 phosphomevalonate kinase

See identical proteins and their annotated locations for NP_001008353.1

Status: PROVISIONAL

Source sequence(s)

BC086349

UniProtKB/TrEMBL

A0A8I5ZXC1, F7FJH6, Q5RK24

Related

ENSRNOP00000028095.3, ENSRNOT00000028095.6

Conserved Domains (1) summary

pfam04275
Location:14 → 123

P-mevalo_kinase; Phosphomevalonate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

177174344..177184076

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102341.2 → XP_038958269.1 phosphomevalonate kinase isoform X1

Conserved Domains (1) summary

cl04466
Location:11 → 135

P-mevalo_kinase; Phosphomevalonate kinase
XM_017590894.3 → XP_017446383.1 phosphomevalonate kinase isoform X2

UniProtKB/TrEMBL

A6J6G7, A6J6G8

Conserved Domains (1) summary

cl04466
Location:1 → 111

P-mevalo_kinase; Phosphomevalonate kinase