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Pmvk phosphomevalonate kinase [ Mus musculus (house mouse) ]

Gene ID: 68603, updated on 17-Nov-2020

Summary

Official Symbol
Pmvkprovided by MGI
Official Full Name
phosphomevalonate kinaseprovided by MGI
Primary source
MGI:MGI:1915853
See related
Ensembl:ENSMUSG00000027952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PMK; PMKA; PMKASE; AV001327; 1110011E12Rik; 2900002L22Rik
Expression
Ubiquitous expression in liver adult (RPKM 24.0), liver E18 (RPKM 22.8) and 28 other tissues See more
Orthologs

Genomic context

See Pmvk in Genome Data Viewer
Location:
3; 3 F1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89361848..89376321)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89454541..89469014)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (89263040..89272931)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pygopus 2 Neighboring gene pre B cell leukemia transcription factor interacting protein 1 Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Neighboring gene adenosine deaminase, RNA-specific Neighboring gene cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphomevalonate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphomevalonate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphomevalonate kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
isopentenyl diphosphate biosynthetic process, mevalonate pathway ISO
Inferred from Sequence Orthology
more info
 
isoprenoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phosphomevalonate kinase
NP_001297569.1
NP_081060.2
NP_081624.1
XP_030108640.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310640.1NP_001297569.1  phosphomevalonate kinase isoform 3

    See identical proteins and their annotated locations for NP_001297569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    BC028659
    Consensus CDS
    CCDS79953.1
    UniProtKB/Swiss-Prot
    Q9D1G2
    Related
    ENSMUSP00000143154.1, ENSMUST00000198440.4
    Conserved Domains (1) summary
    cl04466
    Location:1114
    P-mevalo_kinase; Phosphomevalonate kinase
  2. NM_026784.3NP_081060.2  phosphomevalonate kinase isoform 1

    See identical proteins and their annotated locations for NP_081060.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK003607, AK150483, AW492322, BY266316
    Consensus CDS
    CCDS17511.1
    UniProtKB/Swiss-Prot
    Q9D1G2
    UniProtKB/TrEMBL
    Q3THA3
    Related
    ENSMUSP00000029564.5, ENSMUST00000029564.11
    Conserved Domains (1) summary
    pfam04275
    Location:14123
    P-mevalo_kinase; Phosphomevalonate kinase
  3. NM_027348.1NP_081624.1  phosphomevalonate kinase isoform 2

    See identical proteins and their annotated locations for NP_081624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC171273, AK013477, AK150483, AW492322
    Consensus CDS
    CCDS71270.1
    UniProtKB/Swiss-Prot
    Q9D1G2
    UniProtKB/TrEMBL
    Q3THA3
    Related
    ENSMUSP00000139116.1, ENSMUST00000184515.1
    Conserved Domains (1) summary
    pfam04275
    Location:11102
    P-mevalo_kinase; Phosphomevalonate kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89361848..89376321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252780.2XP_030108640.1  phosphomevalonate kinase isoform X1

    Conserved Domains (1) summary
    cl04466
    Location:1114
    P-mevalo_kinase; Phosphomevalonate kinase
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