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    ppp3ca protein phosphatase 3, catalytic subunit, alpha isozyme [ Danio rerio (zebrafish) ]

    Gene ID: 794574, updated on 25-Apr-2024

    Summary

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    Official Symbol
    ppp3caprovided by ZNC
    Official Full Name
    protein phosphatase 3, catalytic subunit, alpha isozymeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-091113-24
    See related
    Ensembl:ENSDARG00000004988 AllianceGenome:ZFIN:ZDB-GENE-091113-24
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fj46e08; wu:fj46e08; si:dkeyp-79c2.2
    Summary
    Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade. Predicted to be part of calcineurin complex. Predicted to be active in cytosol. Is expressed in brain; heart; integument; and olfactory epithelium. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ppp3ca in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (28958411..29075820)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (28921702..29039125)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene CXXC finger protein 5a Neighboring gene si:dkeyp-79c2.1 Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene T cell immunoglobulin and mucin domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cabin1 expression suggests roles in neuronal development. Hammond DR, et al. Dev Dyn, 2010 Sep. PMID 20652955
    2. Calcineurin controls proximodistal blastema polarity in zebrafish fin regeneration. Cao Z, et al. Proc Natl Acad Sci U S A, 2021 Jan 12. PMID 33376206, Free PMC Article
    3. The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes. Shimizu H, et al. Elife, 2017 Aug 19. PMID 28826496, Free PMC Article
    4. npc2-Deficient Zebrafish Reproduce Neurological and Inflammatory Symptoms of Niemann-Pick Type C Disease. Wiweger M, et al. Front Cell Neurosci, 2021. PMID 33986646, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme
    NP_001185479.1
    XP_005161416.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198550.1 → NP_001185479.1  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

      Status: VALIDATED

      Source sequence(s)
      CR759846, CU463029, DN857140
      UniProtKB/TrEMBL
      A0A8M1NVA3, F1QD93
      Related
      ENSDARP00000024334.6, ENSDART00000005929.9
      Conserved Domains (2) summary
      smart00156
      Location:59 → 328
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:40 → 344
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      28958411..29075820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005161359.4 → XP_005161416.1  protein phosphatase 3, catalytic subunit, alpha isozyme isoform X1

      UniProtKB/TrEMBL
      A0A8M2B8B8, E9QD09
      Related
      ENSDARP00000123171.1, ENSDART00000144331.3
      Conserved Domains (2) summary
      smart00156
      Location:59 → 328
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:40 → 344
      MPP_PP2B; PP2B, metallophosphatase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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