Conserved Protein Domain Family
PP2Ac

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smart00156: PP2Ac 
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Protein phosphatase 2A homologues, catalytic domain.
Large family of serine/threonine phosphatases, that includes PP1, PP2A and PP2B (calcineurin) family members.
Statistics
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PSSM-Id: 197547
View PSSM: smart00156
Aligned: 28 rows
Threshold Bit Score: 266.001
Threshold Setting Gi: 7510798
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00156 is classified as a model that may span more than one domain.
smart00156 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WAO_1       182 LHRKCAYQILVQVKEVLSKLSTLVEttlkE--T-EKITVC---------------------------------------- 218
gi 17544062   36 FCAAELAELCHRARELIWSEPIFLK----L--E-APICVM---------------------------------------- 68
gi 133931102  49 YTKYELMQLIESVEAALSVDDTLAK----I--S-PPVTIV---------------------------------------- 81
gi 71999708   52 LSSNEVWSVCRAVIDEFKKEQNLME----V--S-APVTVI---------------------------------------- 84
gi 70606672    1 MNIEETYELLEKSKDIFRQQGPFIG----EykE-DKVVFV---------------------------------------- 35
gi 17507279   50 FYPEVLKKLLQKSCEVLKQDEMVVK----V--T-GPAVIF---------------------------------------- 82
gi 2073464     1 MQRELPRLLEDAVEVLRRRGPVVRL----G--A-GSVLVA---------------------------------------- 33
gi 71983285   31 FSDSDILEVLKTIKEILEPLPCLIE----I--I-APVVVF---------------------------------------- 63
gi 17506745   37 SPVNCQDMLKRYEIYELCLRARELF----W--T-QPLYRHvevpvtivgdihgqfedlkmmmdmngwpftedeakemckn 109
gi 2330005    11 AAKEELLLLLPEIDRIFDSEPAVLR----I--DtEPVMIV---------------------------------------- 44
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WAO_1       219 ----GDTHGQFYDLLNIF---------------ELN-----------------------------------------G-L 237
gi 17544062   69 ----GDIHGQFDDLLAML---------------DMNgwplssqefealkdttvrsretgkrpqsephstqpessndvK-P 128
gi 133931102  82 ----GDIHGQYPDLVRVLcnqnsk----edakkKAA-----------------------------------------Y-G 111
gi 71999708   85 ----GDVHGNFHDLYRALlarteqditdeqksnFST-----------------------------------------R-Q 118
gi 70606672   36 ----GDTHGAINVTEYVF---------------RK------------------------------------------F-Y 53
gi 17507279   83 ----GPVYGEGDSMISLM---------------SLA-----------------------------------------KkV 102
gi 2073464    34 ----GDTHGYPEVSRWVL---------------GLA-----------------------------------------D-E 52
gi 71983285   64 ----GDIHGQLGDLLQFT---------------NEV-----------------------------------------G-R 82
gi 17506745  110 lllkGGKDGKQTFPAVLG---------------SGT-----------------------------------------DrQ 133
gi 2330005    45 ----GDIHGNLQALEYVI---------------EKR-----------------------------------------E-E 63
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WAO_1       238 P-------------SETNpYIFNGDFVDRGSF-SVEVILTLFGFKLLYPDH-----FHLLRGNHETDNMN--QI------ 290
gi 17544062  129 PvaapksvnkevttGYKR-YLFLGDYVDRGPF-SMEVVILLTALKLAYPDR-----IYLLRGNHESRSVN--TS------ 193
gi 133931102 112 F-------------CNSR-FVFLGDYVDRGHH-SIECISLVFALKVVYPTN-----YILLRGNHETKSIN--YT------ 163
gi 71999708  119 F-------------VRDK-YVFLGNYIDKGPR-SIECICLLFAFKICFPQK-----YILLRGPHECPSVNssEF------ 172
gi 70606672   54 D-------------NVDL-IVFLGDYVDREPQtGVENLSLILKKLIESDENkgktkIVVLRGNHESPLTN--FH------ 111
gi 17507279  103 P-------------PEQT-YVMLGCYLGRGFA-QIECLVFLLAYKILHPEK-----VVLLKGHHEESISI--EMlkvkew 160
gi 2073464    53 L-------------GVDA-VVFLGDYVDRGPR-GVENLSLLVERLLAEPGR-----VVLLRGNHESPSMN--LY------ 104
gi 71983285   83 P-------------PDFQ-YLFLGDYVDRGPN-SLEVTVWLFCMKILFSKK-----VHLLRGNHEVRRVN--TM------ 134
gi 17506745  134 K-------------TQKN-YLFLGDYVDRGPY-SIEVVLMLFAMHLRWPDR-----VTLLRGNHESRPVN---------- 183
gi 2330005    64 M-------------NYKN-FLFLGDYVDRGPQ-GTEALIRLFRMKLEDPDH-----IFLLRGNHETVDMN--IY------ 115
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WAO_1       291 ---YGFEGEVKAKY--TA----Q--------------MYELFSEVFEWLPLAQCINGKVLIMHGGLfS-------E---- 336
gi 17544062  194 ---YGFYREVNYRY--DA----Q--------------LYECFQNMFNVFPFCAVINNTIMCMHGGI-S-------E---- 238
gi 133931102 164 ---YGFREELVNRL--GPidgfE--------------IWERFNVAFSWMPLACLVGHKILCMHGGI-S-------P---- 212
gi 71999708  173 ---LGVMETFSPNH--FK----K--------------IHKKFNEAFSWMPLAAVVGQKILCVHGGI-S-------P---- 217
gi 70606672  112 ---YGFFEELKIKTedAE----N--------------AYEKFRDLFSYMPYSVLVNG-YLCMHGGL-PatlegdrL---- 164
gi 17507279  161 lmaRGIERDVDL-----E----E--------------CMIEMKRACSMMSAAAVIDSKILCMPGGP-G-------Pt--- 206
gi 2073464   105 ---YGFRGEFAAKV--GV----E--------------HLDILHGFYSCLPYAALMGR-VLLVHGGV-P-------Crecq 152
gi 71983285  135 ---YGFKEEMMRKR--NS----H--------------LWKVFNDVFAELSICASINRKILCMHGGI-S-------P---- 179
gi 17506745  184 -----------------R----QygfygecvrryserIYEVFQLAFNAMPLTAIVNKRIMCMHGGI-S-------E---- 230
gi 2330005   116 ---YGFFAEIGFDE--------E--------------FLFRVSQTYDKMPIAAVLSGHTFCVHGGI-N-------Gig-- 160
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WAO_1       337 --DGVTLDDIRKIER-N--R-QPPDSGPMCDLLWSDP-----------Q--PQNGRSIS-K-RGVS-CQFGPDVTKAFLE 394
gi 17544062  239 --HLTSFNQFSVFKR-P--L-EIPDVGVLTDLTWADPd----------P--TEKGYKPS-A-RGAS-FVFGPPALRAFLK 297
gi 133931102 213 --KLHSLKEINEIDR-P--VaEILPDSLAQDLLWADPadgqg--amtvR--STPEYVPNgV-RGLS-FIFNEAAVRDTCK 281
gi 71999708  218 --RLTSWEDIRKIKR-Pl-K-DATEDPLATDLLFADTldfdl--ihipT--RKPKYEFNvI-RNMS-VMYNEAAVTQFCE 286
gi 70606672  165 --GITTVEDIAKLKY-P--D-INPDDPVGLQILWNDPr----------DglLDIDFLPS-I-RGEGiYYFGERVTNEFLS 226
gi 17507279  207 -iREKGLQKLVGLKKgV--Q-AIADKKLLMEASWSVL--------------LLDDAQKD-M-HGMP-F-FTPQQATDFCK 264
gi 2073464   153 ggPEEPLR-LGEIEe----R-LRGLFCRRWLLEWGDSvavqllwndprG--ELDWFAPS-LrGPGI-YYYGRLAWKGFLE 222
gi 71983285  180 --KIESWDSLTGMTK-PrvH-GDCEHGLIVDLIWSDPn----------R--KDDTIQFN-KmRGIS-TLFGKSVVDNLCT 241
gi 17506745  231 --ELFDLKQLDALKRp---I-DTPDIGIIADLTWADP-----------E--CEIDYYKE-SpRGAG-KIFGAKAVDEFCK 289
gi 2330005   161 ------------------sI-NDIRKEKAFPYLWNDP-----------S--NHPGLTAS-RrGSTV-KEFGPDIVDGFLK 206
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1WAO_1       395 ENNLDYIIRSHEVKA-----------EGYEVAHGG-----RCVTVFSAPNYCDQMGNKASYIHLqGSD------------ 446
gi 17544062  298 KLDLQMVIRGHQVVE-----------DGYEFFDGR-----RLVTIFSAPNYCGQNDNTAAVFSI-DKK------------ 348
gi 133931102 282 RLNINLIVRAHQMIP-----------EGFKFFADQ-----KLLTIFSAPRYMNETDNHGATLRV-ETD------------ 332
gi 71999708  287 KFNLKLIIRSHMKVP-----------FGYRFFSEK-----RLITIFNSTGFQNE-SNYGAVLKI-DGN------------ 336
gi 70606672  227 YNNFKGIIRGHEAV------------DGFRTNMNG-----KVITVFSSVYHGQRSGILYHDYNN-NKF------------ 276
gi 17507279  265 ANNLKCIVRGRQMVD-----------EGYLNKP-R-----EVVTLISAVAYLDNFRNHAAVLQV-DNDkgkvirykmeeg 326
gi 2073464   223 ANGLELIVRAHEAVD------------AHHVWTSSgrpvhGLEHGYTMGLEELRGSVVTVFSSL-YHG------------ 277
gi 71983285  242 TLAIDLIIRAHEMKEvyvfhlylssmKGHTFEFDN-----RLLTVFSAPYYSGHNSNLGSVATI-SKS------------ 303
gi 17506745  290 HFQLDLIVRAHQVVQ-----------DGYEFFADR-----KLVTIFSAPFYCGQTNNIASMLNI-DKD------------ 340
gi 2330005   207 TNHLKRIVRGHTALD-----------KGYRWWFDG-----KLLSLFSCPDYVG-LGNAAAFALF-EKE------------ 256
                        490
                 ....*....|..
1WAO_1       447 LRPQFHQFTAVP 458
gi 17544062  349 LKISINVFRPES 360
gi 133931102 333 GKLNIGRFRHKK 344
gi 71999708  337 AKITIISLLPQQ 348
gi 70606672  277 VRIYIKMVNDQl 288
gi 17507279  327 EQLSLELVKPGM 338
gi 2073464   278 AGAGALLLREGE 289
gi 71983285  304 LKLRIVTLKPNK 315
gi 17506745  341 MVasfmlvkpvt 352
gi 2330005   257 EIKLFVFGDQQE 268
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