telo2 TEL2, telomere maintenance 2, homolog (S. cerevisiae) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: telo2provided by ZNC
Official Full Name: TEL2, telomere maintenance 2, homolog (S. cerevisiae)provided by ZNC
Primary source: ZFIN:ZDB-GENE-061103-523
See related: Ensembl:ENSDARG00000000830 AllianceGenome:ZFIN:ZDB-GENE-061103-523
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zC153C20.2; zgc:153824; si:ch211-153c20.2
Summary: Predicted to enable Hsp90 protein binding activity and telomeric DNA binding activity. Predicted to be involved in protein stabilization and telomere maintenance via telomerase. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be part of ASTRA complex. Predicted to be active in cytosol. Is expressed in peripheral olfactory organ. Orthologous to human TELO2 (telomere maintenance 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (37799818..37823488)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (37911921..37935591)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration.
Title: Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration.

Submit: New GeneRIF Correction

General gene information

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Markers

G46732 (e-PCR)
- UniSTS:107530

fj06b05.x1 (e-PCR)
- UniSTS:198417

fb81a08.x1 (e-PCR)
- UniSTS:191601

fb81a08.x1 (e-PCR)
- UniSTS:191602

G39770 (e-PCR)
- UniSTS:46589

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 'de novo' cotranslational protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: telomere length regulation protein TEL2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030218.1 → NP_001025389.1 telomere length regulation protein TEL2 homolog isoform 2

Status: PROVISIONAL

Source sequence(s)

AL772148

UniProtKB/Swiss-Prot

A0JMI8, Q7T006

UniProtKB/TrEMBL

A0A2R8RJV5, A0A8M1N7E4

Related

ENSDARP00000146805.1, ENSDART00000187591.1

Conserved Domains (1) summary

pfam10193
Location:505 → 607

Telomere_reg-2; Telomere length regulation protein
NM_001077741.1 → NP_001071209.1 telomere length regulation protein TEL2 homolog isoform 1

See identical proteins and their annotated locations for NP_001071209.1

Status: PROVISIONAL

Source sequence(s)

BC125895

UniProtKB/Swiss-Prot

A0JMI8, Q7T006

Related

ENSDARP00000114983.2, ENSDART00000131975.3

Conserved Domains (1) summary

pfam10193
Location:505 → 613

Telomere_reg-2; Telomere length regulation protein