Telo2 telomere maintenance 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Telo2provided by MGI
Official Full Name: telomere maintenance 2provided by MGI
Primary source: MGI:MGI:1918968
See related: Ensembl:ENSMUSG00000024170 AllianceGenome:MGI:1918968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tel2; mKIAA0683; 1200003M09Rik
Summary: Enables molecular adaptor activity. Involved in protein stabilization. Predicted to be located in cytoplasm; nuclear body; and nuclear periphery. Predicted to be part of ASTRA complex; TORC1 complex; and TORC2 complex. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human TELO2 (telomere maintenance 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 12.6), limb E14.5 (RPKM 9.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 A3.3

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25318543..25334951, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25099569..25115974, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulating Tel2 expression increases mTOR-mediated cardiomyocyte survival and targeting Tel2 could be another therapeutic strategy against ischemic heart disease
Title: The effects of Tel2 on cardiomyocyte survival.
IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the Tti1/Tel2 complex, thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine 15 to activate the cell death program.
Title: Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.
The CK2 phospho-dependent interaction between TEL2 and the R2TP complex affects phosphatidylinositol 3-kinase-related kinase functions and is essential for mTOR and SMG1 stability in vivo.
Title: CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
Identify Tel2 as a highly conserved regulator of the stability of PI3K-related protein kinases.
Title: Tel2 regulates the stability of PI3K-related protein kinases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI415602 (e-PCR)
- UniSTS:160627

AI661311 (e-PCR)
- UniSTS:166036

Homology

Homologs of the Telo2 gene: The Telo2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 506 organisms have orthologs with human gene Telo2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex stabilizing activity	ISO Inferred from Sequence Orthology more info	PubMed
enables telomeric DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein stabilization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance via telomerase	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
part_of ASTRA complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of TORC1 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
part_of TTT complex	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear periphery	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: telomere length regulation protein TEL2 homolog

Names: TEL2, telomere maintenance 2, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163661.1 → NP_001157133.1 telomere length regulation protein TEL2 homolog

See identical proteins and their annotated locations for NP_001157133.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK143827, AK146963, BB083455

Consensus CDS

CCDS28507.1

UniProtKB/Swiss-Prot

Q91VQ3, Q9DC40

Related

ENSMUSP00000110835.3, ENSMUST00000115181.9

Conserved Domains (1) summary

pfam10193
Location:513 → 621

Telomere_reg-2; Telomere length regulation protein
NM_027880.2 → NP_082156.2 telomere length regulation protein TEL2 homolog

See identical proteins and their annotated locations for NP_082156.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK004582, AK146963, BB083455, BB844017, BQ560945

Consensus CDS

CCDS28507.1

UniProtKB/Swiss-Prot

Q91VQ3, Q9DC40

Related

ENSMUSP00000024987.6, ENSMUST00000024987.6

Conserved Domains (1) summary

pfam10193
Location:513 → 621

Telomere_reg-2; Telomere length regulation protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

25318543..25334951 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160789.1 → XP_036016682.1 telomere length regulation protein TEL2 homolog isoform X1

Conserved Domains (1) summary

pfam10193
Location:200 → 308

Telomere_reg-2; Telomere length regulation protein
XM_036160788.1 → XP_036016681.1 telomere length regulation protein TEL2 homolog isoform X1

Conserved Domains (1) summary

pfam10193
Location:200 → 308

Telomere_reg-2; Telomere length regulation protein
XM_011246618.3 → XP_011244920.1 telomere length regulation protein TEL2 homolog isoform X1

Conserved Domains (1) summary

pfam10193
Location:200 → 308

Telomere_reg-2; Telomere length regulation protein
XM_011246619.4 → XP_011244921.1 telomere length regulation protein TEL2 homolog isoform X2