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    akap10 A kinase (PRKA) anchor protein 10 [ Danio rerio (zebrafish) ]

    Gene ID: 566920, updated on 27-Mar-2024

    Summary

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    Official Symbol
    akap10provided by ZNC
    Official Full Name
    A kinase (PRKA) anchor protein 10provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2535
    See related
    Ensembl:ENSDARG00000059549 AllianceGenome:ZFIN:ZDB-GENE-030131-2535
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc10g11; wu:fc10g11; si:dkey-197m14.4
    Summary
    Predicted to enable protein kinase A binding activity. Acts upstream of or within erythrocyte development and lymphocyte differentiation. Predicted to be active in mitochondrion and plasma membrane. Orthologous to human AKAP10 (A-kinase anchoring protein 10). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See akap10 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (62009729..62045725)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (61346984..61381711)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene EH-domain containing 2a Neighboring gene selenoprotein W, 1 Neighboring gene transmembrane protein 211 Neighboring gene spermatogenesis associated 22 Neighboring gene zgc:85789

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Erythropoietin signaling regulates heme biosynthesis. Chung J, et al. Elife, 2017 May 29. PMID 28553927, Free PMC Article
    2. A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis. Bielczyk-Maczyńska E, et al. PLoS Genet, 2014 Jul. PMID 25010335, Free PMC Article
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein kinase A binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    A kinase anchor protein 10, mitochondrial; A-kinase anchor protein 10, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      62009729..62045725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301915.3 → XP_009300190.1  A-kinase anchor protein 10, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A8M3B9Z5
      Conserved Domains (3) summary
      cd08721
      Location:362 → 482
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd08735
      Location:101 → 346
      RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:598 → 636
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

    2. XM_005165576.4 → XP_005165633.1  A-kinase anchor protein 10, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8M2BCV0, F1QDF6
      Related
      ENSDARP00000077307.5, ENSDART00000082872.6
      Conserved Domains (3) summary
      cd08721
      Location:362 → 482
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd08735
      Location:101 → 346
      RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:598 → 642
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

    3. XM_005165577.4 → XP_005165634.1  A-kinase anchor protein 10, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCX7
      Conserved Domains (3) summary
      cd08721
      Location:362 → 482
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd08735
      Location:101 → 346
      RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:597 → 641
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10
    Nucleotide Protein Strain
    Heading Accession and Version

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