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    daam1a dishevelled associated activator of morphogenesis 1a [ Danio rerio (zebrafish) ]

    Gene ID: 557451, updated on 27-Mar-2024

    Summary

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    Official Symbol
    daam1aprovided by ZNC
    Official Full Name
    dishevelled associated activator of morphogenesis 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030911-6
    See related
    Ensembl:ENSDARG00000015059 AllianceGenome:ZFIN:ZDB-GENE-030911-6
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    daam1
    Summary
    Predicted to enable actin binding activity. Acts upstream of or within habenula development and pronephros development. Predicted to be active in stress fiber. Is expressed in brain and dorsal habenular nucleus. Orthologous to human DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See daam1a in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (14467374..14591756, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (14459441..14583802, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene jnk1/mapk8 associated membrane protein Neighboring gene G protein-coupled receptor 135 Neighboring gene protein phosphatase 1, regulatory subunit 13Ba Neighboring gene serine dehydratase-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling. Miller RK, et al. J Am Soc Nephrol, 2011 Sep. PMID 21804089, Free PMC Article
    2. Comparative gene expression analysis of the fmnl family of formins during zebrafish development and implications for tissue specific functions. Santos-Ledo A, et al. Gene Expr Patterns, 2013 Jan-Feb. PMID 23072729, Free PMC Article
    3. Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth. Colombo A, et al. Development, 2013 Oct. PMID 24046318, Free PMC Article
    4. Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord. Kida YS, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17412835, Free PMC Article
    5. Mechanisms of RhoA inactivation and CDC42 and Rac1 activation during zebrafish optic nerve regeneration. Matsukawa T, et al. Neurochem Int, 2018 Jan. PMID 29129556

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results indicate that Daam1a plays a key role in asymmetric habenular morphogenesis mediating the growth of dendritic and axonal processes in dorsal habenular neurons.
      Title: Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth.
    2. Pronephric tubulogenesis requires the Daam1/WGEF/Rho PCP pathway.
      Title: Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling.
    3. Daam1 is a dynamic coordinator of endocytosis and cytoskeletal remodeling underlying the convergent extension movement of notochord cells.
      Title: Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular component organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within habenula development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within habenula development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    disheveled-associated activator of morphogenesis 1
    Names
    dishevelled associated activator of morphogenesis 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      14467374..14591756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351772.2 → XP_017207261.1  disheveled-associated activator of morphogenesis 1 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IER9, A0A8M6YT98
      Related
      ENSDARP00000143770.1, ENSDART00000174703.2
      Conserved Domains (4) summary
      pfam02181
      Location:595 → 966
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:236 → 440
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:46 → 233
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19219
      Location:447 → 525
      DUF342; Protein of unknown function (DUF342)

    2. XM_017351771.2 → XP_017207260.1  disheveled-associated activator of morphogenesis 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2D8
      Conserved Domains (4) summary
      pfam02181
      Location:595 → 975
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:236 → 440
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:46 → 233
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19219
      Location:447 → 525
      DUF342; Protein of unknown function (DUF342)

    3. XM_702261.9 → XP_707353.4  disheveled-associated activator of morphogenesis 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z2D8
      Conserved Domains (4) summary
      pfam02181
      Location:595 → 975
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:236 → 440
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:46 → 233
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19219
      Location:447 → 525
      DUF342; Protein of unknown function (DUF342)
    Nucleotide Protein Strain
    Heading Accession and Version

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