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Daam1 dishevelled associated activator of morphogenesis 1 [ Mus musculus (house mouse) ]

Gene ID: 208846, updated on 6-Jun-2024

Summary

Official Symbol
Daam1provided by MGI
Official Full Name
dishevelled associated activator of morphogenesis 1provided by MGI
Primary source
MGI:MGI:1914596
See related
Ensembl:ENSMUSG00000034574 AllianceGenome:MGI:1914596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within Wnt signaling pathway. Located in stress fiber. Is expressed in several structures, including central nervous system; embryo mesenchyme; eye; genitourinary system; and gut. Used to study intrinsic cardiomyopathy. Orthologous to human DAAM1 (dishevelled associated activator of morphogenesis 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 12.5), whole brain E14.5 (RPKM 8.6) and 25 other tissues See more
Orthologs
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Genomic context

See Daam1 in Genome Data Viewer
Location:
12 30.06 cM; 12 C3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71877834..72039150)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (71830950..71992376)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9630002D21 gene Neighboring gene STARR-seq mESC enhancer starr_32425 Neighboring gene predicted gene, 46356 Neighboring gene STARR-seq mESC enhancer starr_32426 Neighboring gene STARR-seq mESC enhancer starr_32427 Neighboring gene UPF0538 protein C2orf76 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_32428 Neighboring gene STARR-positive B cell enhancer ABC_E5334 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_32431 Neighboring gene predicted gene, 53214 Neighboring gene predicted gene, 40440

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • mKIAA0666, E130308H01, 1700066F09Rik, 2310028E21Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disheveled-associated activator of morphogenesis 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286452.1NP_001273381.1  disheveled-associated activator of morphogenesis 1 isoform b

    See identical proteins and their annotated locations for NP_001273381.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter, compared to isoform a.
    Source sequence(s)
    AC159186, AK033683, AK147480, AK162231, BC076585
    Consensus CDS
    CCDS88349.1
    UniProtKB/TrEMBL
    Q6ZQ74
    Related
    ENSMUSP00000152532.2, ENSMUST00000221317.2
    Conserved Domains (4) summary
    PRK12704
    Location:444513
    PRK12704; phosphodiesterase; Provisional
    pfam02181
    Location:600973
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:235439
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:45232
    Drf_GBD; Diaphanous GTPase-binding Domain
  2. NM_001422845.1NP_001409774.1  disheveled-associated activator of morphogenesis 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124356, AC159186
    UniProtKB/TrEMBL
    Q6ZQ74
  3. NM_001422846.1NP_001409775.1  disheveled-associated activator of morphogenesis 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC124356, AC159186
    UniProtKB/TrEMBL
    Q6ZQ74
  4. NM_026102.3NP_080378.2  disheveled-associated activator of morphogenesis 1 isoform a

    See identical proteins and their annotated locations for NP_080378.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC124356, AK033683, AK162231, BC076585, CD352113
    Consensus CDS
    CCDS25964.1
    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Related
    ENSMUSP00000082406.3, ENSMUST00000085299.4
    Conserved Domains (4) summary
    PRK12704
    Location:444513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45232
    Drf_GBD; Diaphanous GTPase-binding Domain
  5. NM_172464.3NP_766052.2  disheveled-associated activator of morphogenesis 1 isoform a

    See identical proteins and their annotated locations for NP_766052.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC124356, AK033683, AK162231, BC076585
    Consensus CDS
    CCDS25964.1
    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Related
    ENSMUSP00000152564.2, ENSMUST00000223272.2
    Conserved Domains (4) summary
    PRK12704
    Location:444513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45232
    Drf_GBD; Diaphanous GTPase-binding Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    71877834..72039150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246636.1XP_030102496.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Conserved Domains (4) summary
    PRK12704
    Location:444513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45232
    Drf_GBD; Diaphanous GTPase-binding Domain
  2. XM_036157296.1XP_036013189.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Conserved Domains (4) summary
    PRK12704
    Location:444513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45232
    Drf_GBD; Diaphanous GTPase-binding Domain
  3. XM_036157297.1XP_036013190.1  disheveled-associated activator of morphogenesis 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Conserved Domains (4) summary
    PRK12704
    Location:444513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45232
    Drf_GBD; Diaphanous GTPase-binding Domain
  4. XM_006515642.4XP_006515705.1  disheveled-associated activator of morphogenesis 1 isoform X1

    See identical proteins and their annotated locations for XP_006515705.1

    UniProtKB/Swiss-Prot
    Q3UHB4, Q6DFY0, Q6TAB8, Q80Y68, Q8BPM0, Q9CQQ2
    UniProtKB/TrEMBL
    Q6ZQ74
    Conserved Domains (4) summary
    PRK12704
    Location:444513
    PRK12704; phosphodiesterase; Provisional
    pfam06367
    Location:235439
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:600982
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:45232
    Drf_GBD; Diaphanous GTPase-binding Domain