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    fto FTO alpha-ketoglutarate dependent dioxygenase [ Danio rerio (zebrafish) ]

    Gene ID: 553363, updated on 17-Sep-2024

    Summary

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    Official Symbol
    ftoprovided by ZNC
    Official Full Name
    FTO alpha-ketoglutarate dependent dioxygenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061108-1
    See related
    Ensembl:ENSDARG00000044216 AllianceGenome:ZFIN:ZDB-GENE-061108-1
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Acts upstream of or within several processes, including cilium assembly; left/right pattern formation; and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (36111331..36358340, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (35839993..36086821, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496182 Neighboring gene iroquois homeobox 3a Neighboring gene uncharacterized LOC137496183 Neighboring gene nucleolar protein 58-like Neighboring gene akt interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization and expression analysis of fat mass and obesity-associated gene in rabbit. Xing J, et al. J Genet, 2013 Dec. PMID 24371169
    2. Obesity-associated variants within FTO form long-range functional connections with IRX3. Smemo S, et al. Nature, 2014 Mar 20. PMID 24646999, Free PMC Article
    3. Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies. Osborn DP, et al. PLoS One, 2014. PMID 24503721, Free PMC Article
    4. Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. Sun Q, et al. Int J Biol Sci, 2017. PMID 28924386, Free PMC Article
    5. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Ragvin A, et al. Proc Natl Acad Sci U S A, 2010 Jan 12. PMID 20080751, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.
      Title: Loss of FTO antagonises Wnt signaling and leads to developmental defects associated with ciliopathies.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables broad specificity oxidative DNA demethylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables broad specificity oxidative DNA demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA N6-methyladenosine dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA N6-methyladenosine dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidative RNA demethylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA alkylation repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chordate embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within left/right pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein fto; alpha-ketoglutarate-dependent dioxygenase FTO
    Names
    fat mass and obesity associated
    XP_001345910.5
    XP_009301626.1
    XP_021327673.1
    XP_021327674.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      36111331..36358340 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009303351.4 → XP_009301626.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

      UniProtKB/TrEMBL
      A0A2R8PY24, A0A8M9PKY4
      Related
      ENSDARP00000145984.1, ENSDART00000188392.1
      Conserved Domains (2) summary
      pfam12933
      Location:47 → 401
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:405 → 574
      FTO_CTD; FTO C-terminal domain

    2. XM_001345874.8 → XP_001345910.5  alpha-ketoglutarate-dependent dioxygenase FTO isoform X2

      Related
      ENSDARP00000107656.2, ENSDART00000130028.4

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394700.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      37818..269274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021471999.2 → XP_021327674.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X3

      UniProtKB/TrEMBL
      A0A8M1PZX3
      Conserved Domains (2) summary
      pfam12933
      Location:47 → 401
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:405 → 574
      FTO_CTD; FTO C-terminal domain

    2. XM_021471998.2 → XP_021327673.1  alpha-ketoglutarate-dependent dioxygenase FTO isoform X1

      UniProtKB/TrEMBL
      A0A2R8PY24, A0A8M9PKY4
      Conserved Domains (2) summary
      pfam12933
      Location:47 → 401
      FTO_NTD; FTO catalytic domain
      pfam12934
      Location:405 → 574
      FTO_CTD; FTO C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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