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    osr2 odd-skipped related transciption factor 2 [ Danio rerio (zebrafish) ]

    Gene ID: 550389, updated on 27-Mar-2024

    Summary

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    Official Symbol
    osr2provided by ZNC
    Official Full Name
    odd-skipped related transciption factor 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-183
    See related
    Ensembl:ENSDARG00000038006 AllianceGenome:ZFIN:ZDB-GENE-050417-183
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:111995
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within pectoral fin development and pronephros development. Predicted to be active in nucleus. Is expressed in several structures, including gut; intestinal rod; mesoderm; pectoral fin; and pronephros. Orthologous to human OSR2 (odd-skipped related transciption factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See osr2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (54402310..54405982, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (54698367..54707551, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting-associated protein 13B-like Neighboring gene vacuolar protein sorting-associated protein 13B Neighboring gene vegetative cell wall protein gp1-like Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Shared acquired genomic changes in zebrafish and human T-ALL. Rudner LA, et al. Oncogene, 2011 Oct 13. PMID 21552289, Free PMC Article
    2. The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development. Neto A, et al. Development, 2012 Jan. PMID 22129829
    3. Odd-skipped genes encode repressors that control kidney development. Tena JJ, et al. Dev Biol, 2007 Jan 15. PMID 17011543
    4. odd-skipped related 2 is required for fin chondrogenesis in zebrafish. Lam PY, et al. Dev Dyn, 2013 Nov. PMID 23913342, Free PMC Article
    5. Examination of a palatogenic gene program in zebrafish. Swartz ME, et al. Dev Dyn, 2011 Sep. PMID 22016187, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
      Title: The Osr1 and Osr2 genes act in the pronephric anlage downstream of retinoic acid signaling and upstream of Wnt2b to maintain pectoral fin development.
    2. Odd genes may also be required for proper development of the Malpighian tubules, the Drosophila renal organs
      Title: Odd-skipped genes encode repressors that control kidney development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within kidney development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pectoral fin development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pectoral fin development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urogenital system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein odd-skipped-related 2
    Names
    odd-skipped related 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017694.1 → NP_001017694.1  protein odd-skipped-related 2

      See identical proteins and their annotated locations for NP_001017694.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093148
      UniProtKB/Swiss-Prot
      Q567J8
      UniProtKB/TrEMBL
      B2GRK2
      Related
      ENSDARP00000055394.4, ENSDART00000055395.6
      Conserved Domains (2) summary
      sd00017
      Location:136 → 156
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:148 → 173
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      54402310..54405982 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173555.4 → XP_005173612.1  protein odd-skipped-related 2 isoform X1

      See identical proteins and their annotated locations for XP_005173612.1

      UniProtKB/TrEMBL
      A0A8M2BKT6
      Conserved Domains (4) summary
      COG5048
      Location:55 → 276
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:136 → 156
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:218 → 240
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:148 → 173
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q567J8.1 GenPept UniProtKB/Swiss-Prot:Q567J8

    Gene LinkOut

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