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    DGKB diacylglycerol kinase beta [ Bos taurus (cattle) ]

    Gene ID: 537171, updated on 3-Apr-2024

    Summary

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    Official Symbol
    DGKBprovided by VGNC
    Official Full Name
    diacylglycerol kinase betaprovided by VGNC
    Primary source
    VGNC:VGNC:28025
    See related
    BGD:BT21522; Ensembl:ENSBTAG00000021905
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (22386958..23262292, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345069 Neighboring gene ETS variant transcription factor 1 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene U6 spliceosomal RNA Neighboring gene alkylglycerol monooxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase beta
    Names
    diacylglycerol kinase, beta 90kDa
    NP_001179827.1
    XP_005205258.1
    XP_010802346.1
    XP_015323826.1
    XP_059741657.1
    XP_059741658.1
    XP_059741659.1
    XP_059741660.1
    XP_059741661.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192898.1 → NP_001179827.1  diacylglycerol kinase beta

      See identical proteins and their annotated locations for NP_001179827.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000004
      UniProtKB/TrEMBL
      A0A3Q1M6H5, E1B7U7
      Related
      ENSBTAP00000053176.3, ENSBTAT00000061250.3
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:244 → 293
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:309 → 360
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22386958..23262292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885674.1 → XP_059741657.1  diacylglycerol kinase beta isoform X1

      UniProtKB/TrEMBL
      E1B7U7

    2. XM_059885677.1 → XP_059741660.1  diacylglycerol kinase beta isoform X5

    3. XM_015468340.3 → XP_015323826.1  diacylglycerol kinase beta isoform X1

      UniProtKB/TrEMBL
      A0A3Q1M6H5, E1B7U7
      Conserved Domains (6) summary
      smart00045
      Location:581 → 761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439 → 560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:244 → 293
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:309 → 360
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    4. XM_059885675.1 → XP_059741658.1  diacylglycerol kinase beta isoform X1

      UniProtKB/TrEMBL
      E1B7U7

    5. XM_059885678.1 → XP_059741661.1  diacylglycerol kinase beta isoform X6

    6. XM_005205201.5 → XP_005205258.1  diacylglycerol kinase beta isoform X3

      See identical proteins and their annotated locations for XP_005205258.1

      UniProtKB/TrEMBL
      A0A3Q1NNM0
      Conserved Domains (6) summary
      smart00045
      Location:574 → 754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432 → 553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:237 → 286
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:145 → 214
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:302 → 353
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7 → 141
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    7. XM_059885676.1 → XP_059741659.1  diacylglycerol kinase beta isoform X2

    8. XM_010804044.4 → XP_010802346.1  diacylglycerol kinase beta isoform X4

      See identical proteins and their annotated locations for XP_010802346.1

      UniProtKB/TrEMBL
      A0A3Q1NNM0
      Related
      ENSBTAP00000072828.2, ENSBTAT00000082627.2
      Conserved Domains (6) summary
      smart00045
      Location:573 → 753
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:431 → 552
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:237 → 286
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:145 → 214
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:302 → 353
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7 → 141
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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