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    CYP7B1 cytochrome P450 family 7 subfamily B member 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 486973, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CYP7B1provided by VGNC
    Official Full Name
    cytochrome P450 family 7 subfamily B member 1provided by VGNC
    Primary source
    VGNC:VGNC:50379
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 29
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 29 NC_051833.1 (14537942..14712338, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 29 NC_006611.4 (14762658..14936799, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 29 NC_049250.1 (14932049..15106453, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 29 NC_049289.1 (14550483..14724576, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 29 NC_049770.1 (14664658..14838558, complement)

    Chromosome 29 - NC_051833.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119866672 Neighboring gene basic helix-loop-helix family member e22 Neighboring gene uncharacterized LOC102153932 Neighboring gene uncharacterized LOC119866704 Neighboring gene uncharacterized LOC111093165 Neighboring gene programmed cell death protein 6-like Neighboring gene uncharacterized LOC102154275

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables steroid hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bile acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cholesterol homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    25-hydroxycholesterol 7-alpha-hydroxylase; cytochrome P450 7B1
    Names
    cytochrome P450, family 7, subfamily B, polypeptide 1
    XP_005638074.1
    XP_005638076.1
    XP_022268148.1
    XP_038297184.1
    XP_038297185.1
    XP_038297186.1
    XP_038297188.1
    XP_038316791.1
    XP_038371763.1
    XP_038371764.1
    XP_038371765.1
    XP_038371766.1
    XP_038435324.1
    XP_038435325.1
    XP_038435326.1
    XP_038435327.1
    XP_038499571.1
    XP_038499572.1
    XP_038499573.1
    XP_038499574.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051833.1 Reference ROS_Cfam_1.0

      Range
      14537942..14712338 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038441256.1 → XP_038297184.1  cytochrome P450 7B1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RK05, A0A8P0N9M7
      Conserved Domains (1) summary
      cl41757
      Location:66 → 498
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_038441257.1 → XP_038297185.1  cytochrome P450 7B1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NFX8, A0A8C0R1V1
      Conserved Domains (1) summary
      cl41757
      Location:45 → 477
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_038441260.1 → XP_038297188.1  cytochrome P450 7B1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0R1V1
      Conserved Domains (1) summary
      cl41757
      Location:1 → 399
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    4. XM_038441258.1 → XP_038297186.1  cytochrome P450 7B1 isoform X3

      Conserved Domains (1) summary
      cl41757
      Location:66 → 407
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049289.1 Alternate UMICH_Zoey_3.1

      Range
      14550483..14724576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038515835.1 → XP_038371763.1  cytochrome P450 7B1 isoform X1

      Conserved Domains (1) summary
      cl41757
      Location:66 → 498
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_038515836.1 → XP_038371764.1  cytochrome P450 7B1 isoform X2

      Conserved Domains (1) summary
      cl41757
      Location:45 → 477
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_038515838.1 → XP_038371766.1  cytochrome P450 7B1 isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 399
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    4. XM_038515837.1 → XP_038371765.1  cytochrome P450 7B1 isoform X3

      Conserved Domains (1) summary
      cl41757
      Location:66 → 407
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049770.1 Alternate UNSW_CanFamBas_1.0

      Range
      14664658..14838558 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038643643.1 → XP_038499571.1  cytochrome P450 7B1 isoform X1

      Conserved Domains (1) summary
      cl41757
      Location:66 → 498
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_038643644.1 → XP_038499572.1  cytochrome P450 7B1 isoform X2

      Conserved Domains (1) summary
      cl41757
      Location:45 → 477
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_038643646.1 → XP_038499574.1  cytochrome P450 7B1 isoform X4

      Conserved Domains (1) summary
      cl41757
      Location:1 → 399
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    4. XM_038643645.1 → XP_038499573.1  cytochrome P450 7B1 isoform X3

      Conserved Domains (1) summary
      cl41757
      Location:66 → 407
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049250.1 Alternate UU_Cfam_GSD_1.0

      Range
      14932049..15106453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038579396.1 → XP_038435324.1  cytochrome P450 7B1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RK05, A0A8P0N9M7
      Conserved Domains (1) summary
      cl41757
      Location:66 → 498
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_038579397.1 → XP_038435325.1  cytochrome P450 7B1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NFX8, A0A8C0R1V1
      Conserved Domains (1) summary
      cl41757
      Location:45 → 477
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_038579399.1 → XP_038435327.1  cytochrome P450 7B1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0R1V1
      Conserved Domains (1) summary
      cl41757
      Location:1 → 399
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    4. XM_038579398.1 → XP_038435326.1  cytochrome P450 7B1 isoform X3

      Conserved Domains (1) summary
      cl41757
      Location:66 → 407
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006611.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      14762658..14936799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005638017.4 → XP_005638074.1  cytochrome P450 7B1 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RK05, A0A8P0N9M7
      Conserved Domains (1) summary
      cl41757
      Location:66 → 498
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_022412440.2 → XP_022268148.1  cytochrome P450 7B1 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NFX8, A0A8C0R1V1
      Conserved Domains (1) summary
      cl41757
      Location:45 → 477
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_005638019.3 → XP_005638076.1  cytochrome P450 7B1 isoform X4

      UniProtKB/TrEMBL
      A0A8C0R1V1
      Conserved Domains (1) summary
      cl41757
      Location:1 → 399
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    4. XM_038460863.1 → XP_038316791.1  cytochrome P450 7B1 isoform X3

      Conserved Domains (1) summary
      cl41757
      Location:66 → 407
      cytochrome_P450; cytochrome P450 (CYP) superfamily
    Nucleotide Protein
    Heading Accession and Version

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