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Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13123, updated on 8-Dec-2022

Summary

Official Symbol
Cyp7b1provided by MGI
Official Full Name
cytochrome P450, family 7, subfamily b, polypeptide 1provided by MGI
Primary source
MGI:MGI:104978
See related
Ensembl:ENSMUSG00000039519 AllianceGenome:MGI:104978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hct-1; D3Ertd552e
Summary
Enables oxysterol 7-alpha-hydroxylase activity. Involved in B cell chemotaxis and bile acid biosynthetic process. Acts upstream of or within negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of epithelial cell proliferation; and prostate gland epithelium morphogenesis. Predicted to be located in intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in congenital bile acid synthesis defect 3 and hereditary spastic paraplegia 5A. Orthologous to human CYP7B1 (cytochrome P450 family 7 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 7.2), bladder adult (RPKM 3.2) and 19 other tissues See more
Orthologs
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Genomic context

See Cyp7b1 in Genome Data Viewer
Location:
3 A1; 3 4.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (18126108..18298054, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (18071944..18243890, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene basic helix-loop-helix family, member e22 Neighboring gene predicted gene, 23686 Neighboring gene predicted gene, 30667 Neighboring gene RIKEN cDNA 4930433B08 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 24-hydroxycholesterol 7alpha-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables 25-hydroxycholesterol 7alpha-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables 27-hydroxycholesterol 7-alpha-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables oxysterol 7-alpha-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxysterol 7-alpha-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxysterol 7-alpha-hydroxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bile acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in bile acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in digestion TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 7B1
Names
24-hydroxycholesterol 7-alpha-hydroxylase
25-hydroxycholesterol 7-alpha-hydroxylase
25/26-hydroxycholesterol 7-alpha-hydroxylase
3-hydroxysteroid 7-alpha hydroxylase
cytochrome P450, 7b1
hippocampal transcript 1 protein
oxysterol 7-alpha-hydroxylase
NP_031851.3
XP_006535446.1
XP_006535447.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409876.1NP_001396805.1  cytochrome P450 7B1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100500, AC161213
  2. NM_007825.5NP_031851.3  cytochrome P450 7B1 isoform 1

    See identical proteins and their annotated locations for NP_031851.3

    Status: VALIDATED

    Source sequence(s)
    AC100500, AC161213
    Consensus CDS
    CCDS17254.1
    UniProtKB/Swiss-Prot
    Q60991, Q9CZ39
    UniProtKB/TrEMBL
    Q3USU4
    Related
    ENSMUSP00000037487.7, ENSMUST00000035625.7
    Conserved Domains (1) summary
    cl12078
    Location:50487
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    18126108..18298054 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535384.2XP_006535447.1  cytochrome P450 7B1 isoform X2

    Conserved Domains (1) summary
    cl12078
    Location:50333
    p450; Cytochrome P450
  2. XM_006535383.3XP_006535446.1  cytochrome P450 7B1 isoform X1

    See identical proteins and their annotated locations for XP_006535446.1

    UniProtKB/Swiss-Prot
    Q60991, Q9CZ39
    Conserved Domains (1) summary
    cl12078
    Location:50487
    p450; Cytochrome P450