SYT1 synaptotagmin 1 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: SYT1provided by VGNC
Official Full Name: synaptotagmin 1provided by VGNC
Primary source: VGNC:VGNC:5610
Locus tag: CK820_G0020286
See related: Ensembl:ENSPTRG00000024064
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	10	NC_072408.2 (85658867..86247605)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	12	NC_072410.1 (84276222..84864897)

Chromosome 10 - NC_072408.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-31415 (e-PCR)
- UniSTS:33281

WI-22639 (e-PCR)
- UniSTS:76810

SYT1_862 (e-PCR)
- UniSTS:277780

SHGC-31058 (e-PCR)
- UniSTS:64539

G09678 (e-PCR)
- UniSTS:21026

D12S1421 (e-PCR)
- UniSTS:80438

SHGC-84895 (e-PCR)
- UniSTS:104788

D12F314S2 (e-PCR)
- UniSTS:70493

SHGC-30056 (e-PCR)
- UniSTS:2399

RH78549 (e-PCR)
- UniSTS:63327

G31550 (e-PCR)
- UniSTS:78177

WI-17968 (e-PCR)
- UniSTS:82536

RH17699 (e-PCR)
- UniSTS:72557

A002S37 (e-PCR)
- UniSTS:55926

D12S64 (e-PCR)
- UniSTS:147835

SHGC-84114 (e-PCR)
- UniSTS:104571

SHGC-110880 (e-PCR)
- UniSTS:168066

SHGC-59569 (e-PCR)
- UniSTS:3474

D37792 (e-PCR)
- UniSTS:124827

SHGC-85231 (e-PCR)
- UniSTS:104367

SHGC-111536 (e-PCR)
- UniSTS:168385

SHGC-111560 (e-PCR)
- UniSTS:168398

STS-AA040166 (e-PCR)
- UniSTS:30439

G65584 (e-PCR)
- UniSTS:225518

RH47944 (e-PCR)
- UniSTS:74237

RH47304 (e-PCR)
- UniSTS:27901

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables clathrin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion-regulated exocytosis of neurotransmitter	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to calcium ion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of dopamine secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in synaptic vesicle endocytosis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in dense core granule	IEA Inferred from Electronic Annotation more info	PubMed
located_in exocytic vesicle	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: synaptotagmin-1

Names: synaptotagmin I

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

85658867..86247605

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016923901.3 → XP_016779390.1 synaptotagmin-1 isoform X1

UniProtKB/TrEMBL

A0A2J8MIV5, A0A6D2VY16, H2R3R2

Conserved Domains (3) summary

cd08385
Location:143 → 265

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:274 → 409

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cd21963
Location:6 → 113

Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
XM_016923903.3 → XP_016779392.1 synaptotagmin-1 isoform X2

UniProtKB/TrEMBL

A0A2J8MIW2

Conserved Domains (3) summary

cd08385
Location:140 → 262

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:271 → 406

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cd21963
Location:6 → 113

Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
XM_016923902.3 → XP_016779391.1 synaptotagmin-1 isoform X1

UniProtKB/TrEMBL

A0A2J8MIV5, A0A6D2VY16, H2R3R2

Related

ENSPTRP00000045927.4

Conserved Domains (3) summary

cd08385
Location:143 → 265

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:274 → 409

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cd21963
Location:6 → 113

Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
XM_009425895.4 → XP_009424170.1 synaptotagmin-1 isoform X2

See identical proteins and their annotated locations for XP_009424170.1

UniProtKB/TrEMBL

A0A2J8MIW2

Conserved Domains (3) summary

cd08385
Location:140 → 262

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:271 → 406

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cd21963
Location:6 → 113

Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
XM_054664526.2 → XP_054520501.1 synaptotagmin-1 isoform X1

UniProtKB/TrEMBL

A0A2J8MIV5, A0A6D2VY16, H2R3R2
XM_001162897.6 → XP_001162897.1 synaptotagmin-1 isoform X1

See identical proteins and their annotated locations for XP_001162897.1

UniProtKB/TrEMBL

A0A2J8MIV5, A0A6D2VY16, H2R3R2

Conserved Domains (3) summary

cd08385
Location:143 → 265

C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10

cd08402
Location:274 → 409

C2B_Synaptotagmin-1; C2 domain second repeat present in Synaptotagmin 1

cd21963
Location:6 → 113

Syt1_N; N-terminal domain of synaptotagmin-1 (Syt1) and similar proteins
XM_054664525.2 → XP_054520500.1 synaptotagmin-1 isoform X1

UniProtKB/TrEMBL

A0A2J8MIV5, A0A6D2VY16, H2R3R2