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    DGKA diacylglycerol kinase alpha [ Pan troglodytes (chimpanzee) ]

    Gene ID: 451976, updated on 3-Apr-2024

    Summary

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    Official Symbol
    DGKAprovided by VGNC
    Official Full Name
    diacylglycerol kinase alphaprovided by VGNC
    Primary source
    VGNC:VGNC:5356
    Locus tag
    CK820_G0046577
    See related
    Ensembl:ENSPTRG00000005068
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 10 NC_072408.2 (40058244..40081308, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 12 NC_072410.1 (38732154..38755036, complement)

    Chromosome 10 - NC_072408.2Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 Neighboring gene premelanosome protein Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene obg-like ATPase 1 Neighboring gene U1 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lipid phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    diacylglycerol kinase alpha
    Names
    diacylglycerol kinase, alpha 80kDa
    XP_001169899.1
    XP_001169923.1
    XP_001169946.1
    XP_016778734.2
    XP_016778735.1
    XP_063642648.1
    XP_063642649.1
    XP_063642650.1
    XP_063642651.1
    XP_063642652.1
    XP_063642653.1
    XP_063642654.1
    XP_063642655.1
    XP_063642656.1
    XP_063642657.1
    XP_063642658.1
    XP_063642659.1
    XP_063642660.1
    XP_063642661.1
    XP_063642662.1
    XP_063642663.1
    XP_063642664.1
    XP_063642665.1
    XP_063642666.1
    XP_063642667.1
    XP_063642668.1
    XP_063642669.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      40058244..40081308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001169946.6 → XP_001169946.1  diacylglycerol kinase alpha isoform X4

      See identical proteins and their annotated locations for XP_001169946.1

      UniProtKB/TrEMBL
      A0A2J8Q1B2, A0A6D2WW58, H2Q668, K7C7G3
      Conserved Domains (5) summary
      smart00045
      Location:520 → 701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378 → 499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114 → 183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4 → 110
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    2. XM_063786578.1 → XP_063642648.1  diacylglycerol kinase alpha isoform X2

    3. XM_063786591.1 → XP_063642661.1  diacylglycerol kinase alpha isoform X7

    4. XM_063786583.1 → XP_063642653.1  diacylglycerol kinase alpha isoform X5

    5. XM_063786597.1 → XP_063642667.1  diacylglycerol kinase alpha isoform X8

    6. XM_063786589.1 → XP_063642659.1  diacylglycerol kinase alpha isoform X6

    7. XM_063786593.1 → XP_063642663.1  diacylglycerol kinase alpha isoform X8

    8. XM_063786587.1 → XP_063642657.1  diacylglycerol kinase alpha isoform X6

    9. XM_001169899.5 → XP_001169899.1  diacylglycerol kinase alpha isoform X4

      See identical proteins and their annotated locations for XP_001169899.1

      UniProtKB/TrEMBL
      A0A2J8Q1B2, A0A6D2WW58, H2Q668, K7C7G3
      Conserved Domains (5) summary
      smart00045
      Location:520 → 701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378 → 499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114 → 183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4 → 110
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    10. XM_063786579.1 → XP_063642649.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A2J8Q1B2, A0A6D2WW58, H2Q668

    11. XM_063786592.1 → XP_063642662.1  diacylglycerol kinase alpha isoform X7

    12. XM_063786584.1 → XP_063642654.1  diacylglycerol kinase alpha isoform X5

    13. XM_063786598.1 → XP_063642668.1  diacylglycerol kinase alpha isoform X8

    14. XM_063786590.1 → XP_063642660.1  diacylglycerol kinase alpha isoform X6

    15. XM_063786596.1 → XP_063642666.1  diacylglycerol kinase alpha isoform X8

    16. XM_063786588.1 → XP_063642658.1  diacylglycerol kinase alpha isoform X6

    17. XM_063786595.1 → XP_063642665.1  diacylglycerol kinase alpha isoform X8

    18. XM_001169923.6 → XP_001169923.1  diacylglycerol kinase alpha isoform X4

      See identical proteins and their annotated locations for XP_001169923.1

      UniProtKB/TrEMBL
      A0A2J8Q1B2, A0A6D2WW58, H2Q668, K7C7G3
      Related
      ENSPTRP00000008625.1
      Conserved Domains (5) summary
      smart00045
      Location:520 → 701
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:378 → 499
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:114 → 183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:206 → 254
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:4 → 110
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    19. XM_063786580.1 → XP_063642650.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A2J8Q1B2, A0A6D2WW58, H2Q668

    20. XM_063786581.1 → XP_063642651.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A2J8Q1B2, A0A6D2WW58, H2Q668

    21. XM_063786582.1 → XP_063642652.1  diacylglycerol kinase alpha isoform X4

      UniProtKB/TrEMBL
      A0A2J8Q1B2, A0A6D2WW58, H2Q668

    22. XM_063786599.1 → XP_063642669.1  diacylglycerol kinase alpha isoform X8

    23. XM_063786586.1 → XP_063642656.1  diacylglycerol kinase alpha isoform X5

    24. XM_016923246.4 → XP_016778735.1  diacylglycerol kinase alpha isoform X3

      UniProtKB/TrEMBL
      K7C7G3
      Conserved Domains (5) summary
      smart00045
      Location:558 → 739
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:416 → 537
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00051
      Location:152 → 221
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:244 → 292
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:42 → 148
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    25. XM_016923245.3 → XP_016778734.2  diacylglycerol kinase alpha isoform X1

    26. XM_063786585.1 → XP_063642655.1  diacylglycerol kinase alpha isoform X5

    27. XM_063786594.1 → XP_063642664.1  diacylglycerol kinase alpha isoform X8

    Nucleotide Protein
    Heading Accession and Version

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