MARCKS myristoylated alanine rich protein kinase C substrate [Gallus gallus (chicken)] - Gene

Summary

Symbol: MARCKSprovided by CGNC
Full Name: myristoylated alanine rich protein kinase C substrateprovided by CGNC
Primary source: CGNC:49823
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (64578574..64583336, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (64359294..64364048, complement)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MARCKS phosphorylation does not cause extensive modifications in the peptide structure.
Title: Structural characterization of a neuroblast-specific phosphorylated region of MARCKS.
In conclusion, MARCKS is present and phosphorylated at early stages during the differentiation of PNS cells and precursors, indicating that it might also be important for the differentiation of these tissues.
Title: Early phosphorylation of MARCKS at Ser25 in migrating precursor cells and differentiating peripheral neurons.
a novel consequence of PKC stimulation upon the phosphorylated state of MARCKS in neural cells
Title: A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts.
these results indicate the existence of a functional interaction between actin filaments and MARCKS in cells, and particularly of an action in maintaining a phosphorylation in a region of the N-terminal moiety of MARCKS.
Title: Actin modulation of a MARCKS phosphorylation site located outside the effector domain.
The results indicate that there is a learning-specific increase in membrane-bound, non-phosphorylated MARCKS 24 h after training. This increase might contribute to stabilization of synaptic morphology.
Title: Different forms of MARCKS protein are involved in memory formation in the learning process of imprinting.
findings suggest a complex regulation of MARCKS by phosphorylation during neural development
Title: Identification of the chicken MARCKS phosphorylation site specific for differentiating neurons as Ser 25 using a monoclonal antibody and mass spectrometry.
The most outstanding MARCKS modifications occur at the outer retina, where S25p disappears at the end of embryonic development and where MARCKS is missing in adults. These results suggest diverse functional specializations in the different retinal layers.
Title: MARCKS in advanced stages of neural retina histogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in actin filament bundle	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: myristoylated alanine-rich C-kinase substrate

Names: myristoylated alanine-rich C kinase substrate (MARCKS)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397480.1 → NP_001384409.1 myristoylated alanine-rich C-kinase substrate

Status: VALIDATED

Source sequence(s)

JAENSK010000065

UniProtKB/Swiss-Prot

P16527

Conserved Domains (1) summary

pfam02063
Location:2 → 277

MARCKS; MARCKS family
NM_205480.2 → NP_990811.2 myristoylated alanine-rich C-kinase substrate

Status: VALIDATED

Source sequence(s)

JAENSK010000065

UniProtKB/Swiss-Prot

P16527

Conserved Domains (1) summary

pfam02063
Location:2 → 277

MARCKS; MARCKS family

RNA

NR_173985.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAENSK010000065

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

64578574..64583336 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046938583.1 → XP_046794539.1 myristoylated alanine-rich C-kinase substrate isoform X1

UniProtKB/Swiss-Prot

P16527

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

64359294..64364048 complement

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GenBank, FASTA, Sequence Viewer (Graphics)