U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PDGFA platelet derived growth factor subunit A [ Gallus gallus (chicken) ]

    Gene ID: 374196, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Symbol
    PDGFAprovided by CGNC
    Full Name
    platelet derived growth factor subunit Aprovided by CGNC
    Primary source
    CGNC:49079
    See related
    Ensembl:ENSGALG00010022164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PDGF-A
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PDGFA in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (1998800..2019762, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (1997061..2017989, complement)

    Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101748820 Neighboring gene forkhead box protein L1-like Neighboring gene uncharacterized LOC121106828 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC121106829 Neighboring gene dynein axonemal assembly factor 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization and expression of three forms of cDNA encoding chicken platelet-derived growth factor-A chain. Horiuchi H, et al. Gene, 2001 Jul 11. PMID 11470524
    2. PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression. Yang X, et al. Development, 2008 Nov. PMID 18832396
    3. Platelet-derived growth factor A modulates limb chondrogenesis both in vivo and in vitro. Ataliotis P. Mech Dev, 2000 Jun. PMID 10842055
    4. Platelet-derived growth factor is involved in the differentiation of second heart field-derived cardiac structures in chicken embryos. Bax NA, et al. Dev Dyn, 2009 Oct. PMID 19705434

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results describe the expression patterns of PDGF-A, -C, and their receptor PDGFR-alpha during avian heart development.
      Title: Platelet-derived growth factor is involved in the differentiation of second heart field-derived cardiac structures in chicken embryos.
    2. PDGF signalling activates the PI3 kinase signalling pathway in vivo and activation of this pathway is required for proper N-cadherin expression.
      Title: PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    platelet-derived growth factor subunit A
    Names
    PDGF-A (S1)
    platelet-derived growth factor A chain long form
    platelet-derived growth factor A chain short form type 1
    platelet-derived growth factor A chain short form type 2
    platelet-derived growth factor A-chain
    platelet-derived growth factor alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204306.1 → NP_989637.1  platelet-derived growth factor subunit A preproprotein

      See identical proteins and their annotated locations for NP_989637.1

      Status: VALIDATED

      Source sequence(s)
      AB031023
      UniProtKB/TrEMBL
      Q90WK1, Q90WK3
      Related
      ENSGALP00010032473.1, ENSGALT00010053922.1
      Conserved Domains (2) summary
      smart00141
      Location:94 → 179
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1998800..2019762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1997061..2017989 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous