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Pdgfa platelet derived growth factor, alpha [ Mus musculus (house mouse) ]

Gene ID: 18590, updated on 10-Jan-2023

Summary

Official Symbol
Pdgfaprovided by MGI
Official Full Name
platelet derived growth factor, alphaprovided by MGI
Primary source
MGI:MGI:97527
See related
Ensembl:ENSMUSG00000025856 AllianceGenome:MGI:97527
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PDGF-1
Summary
Predicted to enable several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in digestive tract development and embryonic lung development. Acts upstream of or within several processes, including animal organ development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Located in extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 22.6), colon adult (RPKM 19.0) and 24 other tissues See more
Orthologs
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Genomic context

See Pdgfa in Genome Data Viewer
Location:
5 G2; 5 77.65 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138961769..138986336, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138976014..139000792, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31891 Neighboring gene predicted gene, 38726 Neighboring gene protein kinase, cAMP dependent regulatory, type I beta Neighboring gene dynein, axonemal assembly factor 5 Neighboring gene Sad1 and UNC84 domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-derived growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables platelet-derived growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bone development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell projection assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within digestive tract development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of platelet activation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in platelet-derived growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet-derived growth factor receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in platelet-derived growth factor receptor-alpha signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
part_of platelet-derived growth factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet-derived growth factor subunit A
Names
PDGF A-chain
PDGF subunit A
platelet-derived growth factor A-chain
platelet-derived growth factor alpha polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363271.1NP_001350200.1  platelet-derived growth factor subunit A isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC117698
    Consensus CDS
    CCDS90003.1
    UniProtKB/TrEMBL
    A0A6P5PQK1, G5E891
    Related
    ENSMUSP00000038870.7, ENSMUST00000046901.14
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
  2. NM_008808.4NP_032834.1  platelet-derived growth factor subunit A isoform 1 precursor

    See identical proteins and their annotated locations for NP_032834.1

    Status: VALIDATED

    Source sequence(s)
    AC117698
    Consensus CDS
    CCDS19802.1
    UniProtKB/Swiss-Prot
    P20033
    UniProtKB/TrEMBL
    A0A6P5PTD5, Q99L56
    Related
    ENSMUSP00000075463.8, ENSMUST00000076095.14
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region

RNA

  1. NR_156469.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' exon and lacks the open reading frame found in variant 1.
    Source sequence(s)
    AC117698

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138961769..138986336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254199.2XP_030110059.1  platelet-derived growth factor subunit A isoform X2

    UniProtKB/TrEMBL
    A0A6P5PTD5, Q99L56
    Related
    ENSMUSP00000106521.2, ENSMUST00000110896.2
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
  2. XM_011240971.4XP_011239273.1  platelet-derived growth factor subunit A isoform X1

    See identical proteins and their annotated locations for XP_011239273.1

    UniProtKB/TrEMBL
    A0A6P5PQK1, G5E891
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
  3. XM_036164870.1XP_036020763.1  platelet-derived growth factor subunit A isoform X1

    UniProtKB/TrEMBL
    A0A6P5PQK1, G5E891
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
  4. XM_030254198.2XP_030110058.1  platelet-derived growth factor subunit A isoform X2

    UniProtKB/TrEMBL
    A0A6P5PTD5, Q99L56
    Related
    ENSMUSP00000106522.2, ENSMUST00000110897.8
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region
  5. XM_006504659.5XP_006504722.1  platelet-derived growth factor subunit A isoform X1

    See identical proteins and their annotated locations for XP_006504722.1

    UniProtKB/TrEMBL
    A0A6P5PQK1, G5E891
    Conserved Domains (2) summary
    smart00141
    Location:94181
    PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    pfam04692
    Location:2195
    PDGF_N; Platelet-derived growth factor, N terminal region