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    Osbp oxysterol binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365410, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Osbpprovided by RGD
    Official Full Name
    oxysterol binding proteinprovided by RGD
    Primary source
    RGD:1308069
    See related
    Ensembl:ENSRNOG00000021057 AllianceGenome:RGD:1308069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including phosphatidylinositol-4-phosphate binding activity; sterol binding activity; and sterol transfer activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of secretory granule organization; and positive regulation of tyrosine phosphorylation of STAT protein. Located in cytosol. Orthologous to human OSBP (oxysterol binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 303.3), Heart (RPKM 238.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (218313455..218343263)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (208888697..208918511)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (228395237..228425366)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene PAT1 homolog 1, processing body mRNA decay factor Neighboring gene small nucleolar RNA SNORA32 Neighboring gene ribosomal protein L27A like 8 Neighboring gene small Cajal body-specific RNA 23 like 1 Neighboring gene transfer RNA phenylalanine (anticodon GAA) 1 Neighboring gene transfer RNA lysine (anticodon UUU) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. OSBPL10, RXRA and lipid metabolism confer African-ancestry protection against dengue haemorrhagic fever in admixed Cubans. Sierra B, et al. PLoS Pathog, 2017 Feb. PMID 28241052, Free PMC Article
    2. Tumor-specific usage of alternative transcription start sites in colorectal cancer identified by genome-wide exon array analysis. Thorsen K, et al. BMC Genomics, 2011 Oct 14. PMID 21999571, Free PMC Article
    3. Oxysterol-binding protein (OSBP) enhances replication of intracellular Salmonella and binds the Salmonella SPI-2 effector SseL via its N-terminus. Auweter SD, et al. Microbes Infect, 2012 Feb. PMID 21988961
    4. Fetal asphyxia induces acute and persisting changes in the ceramide metabolism in rat brain. Vlassaks E, et al. J Lipid Res, 2013 Jul. PMID 23625371, Free PMC Article
    5. Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1. Romeo GR, et al. J Biol Chem, 2008 Apr 11. PMID 18230613

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1
      Title: Oxysterol and diabetes activate STAT3 and control endothelial expression of profilin-1 via OSBP1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingomyelin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108927.2 → NP_001102397.1  oxysterol-binding protein 1

      See identical proteins and their annotated locations for NP_001102397.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I0C1, D4A9D8
      Related
      ENSRNOP00000061365.3, ENSRNOT00000065411.3
      Conserved Domains (3) summary
      pfam00169
      Location:3 → 56
      PH; PH domain
      pfam01237
      Location:293 → 662
      Oxysterol_BP; Oxysterol-binding protein
      cl17171
      Location:1 → 64
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      218313455..218343263
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085624.2 → XP_038941552.1  oxysterol-binding protein 1 isoform X1

      Conserved Domains (1) summary
      pfam01237
      Location:148 → 523
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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