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OSBP oxysterol binding protein [ Homo sapiens (human) ]

Gene ID: 5007, updated on 5-Apr-2020

Summary

Official Symbol
OSBPprovided by HGNC
Official Full Name
oxysterol binding proteinprovided by HGNC
Primary source
HGNC:HGNC:8503
See related
Ensembl:ENSG00000110048 MIM:167040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSBP1
Summary
Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 22.9), kidney (RPKM 22.7) and 25 other tissues See more
Orthologs

Genomic context

See OSBP in Genome Data Viewer
Location:
11q12.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (59574398..59615774, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (59341871..59383617, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723575 Neighboring gene tRNA-Lys (anticodon TTT) 3-4 Neighboring gene long intergenic non-protein coding RNA 2739 Neighboring gene tRNA-Phe (anticodon GAA) 2-1 Neighboring gene microRNA 3162 Neighboring gene uncharacterized LOC101927226 Neighboring gene PAT1 homolog 1, processing body mRNA decay factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
intermembrane sterol transfer activity IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxysterol binding TAS
Traceable Author Statement
more info
PubMed 
phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
bile acid biosynthetic process TAS
Traceable Author Statement
more info
 
intracellular cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
sterol transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
oxysterol-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002556.3NP_002547.1  oxysterol-binding protein 1

    See identical proteins and their annotated locations for NP_002547.1

    Status: REVIEWED

    Source sequence(s)
    AF185696, AP000442
    Consensus CDS
    CCDS7974.1
    UniProtKB/Swiss-Prot
    P22059
    Related
    ENSP00000263847.1, ENST00000263847.6
    Conserved Domains (3) summary
    cd13284
    Location:91189
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam00169
    Location:91181
    PH; PH domain
    pfam01237
    Location:418787
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    59574398..59615774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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