RTL4 retrotransposon Gag like 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RTL4provided by HGNC
Official Full Name: retrotransposon Gag like 4provided by HGNC
Primary source: HGNC:HGNC:25214
See related: Ensembl:ENSG00000187823 AllianceGenome:HGNC:25214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Mar4; Mart4; SIRH11; ZCCHC16
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to act upstream of or within cognition and norepinephrine metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: Xq23

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (112083013..112457514)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (110531358..110907626)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (111326241..111700742)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study of biochemical traits in Korcula Island, Croatia.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of biochemical traits in Korcula Island, Croatia. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AL021629 (e-PCR)
- UniSTS:68878

AL032556 (e-PCR)
- UniSTS:93214

AL032613 (e-PCR)
- UniSTS:93222

DXS1059 (e-PCR)
- UniSTS:9773

SHGC-81698 (e-PCR)
- UniSTS:185141

DXS7369 (e-PCR)
- UniSTS:55370

AL031553 (e-PCR)
- UniSTS:51802

AL008893 (e-PCR)
- UniSTS:1119

DXS8021 (e-PCR), detects polymorphism
- UniSTS:45670

WI-18604 (e-PCR)
- UniSTS:59505

DXS1059 (e-PCR)
- UniSTS:30328

RH47718 (e-PCR)
- UniSTS:67218

AL031567 (e-PCR)
- UniSTS:13461

G20691 (e-PCR)
- UniSTS:25254

A006C05 (e-PCR)
- UniSTS:25255

DXS8375 (e-PCR)
- UniSTS:4537

DXS7801 (e-PCR)
- UniSTS:22209

DXS7299 (e-PCR)
- UniSTS:49866

DXS7360 (e-PCR)
- UniSTS:78286

WI-10731 (e-PCR)
- UniSTS:19440

G63165 (e-PCR)
- UniSTS:140282

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cognition	IEA Inferred from Electronic Annotation more info
involved_in norepinephrine metabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retrotransposon Gag-like protein 4

Names: Sushi-Ichi retrotransposon homolog 11; mammalian retrotransposon-derived 4; mammalian retrotransposon-derived protein 4; zinc finger CCHC domain-containing protein 16; zinc finger CCHC-type containing 16; zinc finger, CCHC domain containing 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.