Rtl4 retrotransposon Gag like 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rtl4provided by MGI
Official Full Name: retrotransposon Gag like 4provided by MGI
Primary source: MGI:MGI:3588192
See related: Ensembl:ENSMUSG00000071679 AllianceGenome:MGI:3588192
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mar4; Zcchc16; C230031A03Rik
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Acts upstream of or within cognition and norepinephrine metabolic process. Is expressed in brain; eye; liver; lung; and metanephros. Orthologous to human RTL4 (retrotransposon Gag like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X; X F2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (143471147..143905410)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (144688209..145122414)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sirh11/Zcchc16 is the first SIRH gene to be involved in brain function, instead of just the placenta, as seen in the case of Peg10, Peg11/Rtl1 and Sirh7/Ldoc1
Title: Cognitive Function Related to the Sirh11/Zcchc16 Gene Acquired from an LTR Retrotransposon in Eutherians.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

px-25c5 (e-PCR)
- UniSTS:258358

px-26g8 (e-PCR)
- UniSTS:258363

px-17h7 (e-PCR)
- UniSTS:257350

px-37d12 (e-PCR)
- UniSTS:258389

RH135840 (e-PCR)
- UniSTS:209838

MHAa47f5.seq (e-PCR)
- UniSTS:125181

Homology

Homologs of the Rtl4 gene: The Rtl4 gene is conserved in human, chimpanzee, Rhesus monkey, dog, and rat.
Orthologs from Annotation Pipeline: 159 organisms have orthologs with human gene Rtl4
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cognition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within norepinephrine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: retrotransposon Gag-like protein 4

Names: gag-like protein; mammalian retrotransposon-derived protein 4; sushi-XF2b protein; sushi-ichi-related retrotransposon homolog 11; zinc finger CCHC domain-containing protein 16; zinc finger, CCHC domain containing 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.