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    lrrfip2 leucine rich repeat (in FLII) interacting protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 335838, updated on 27-Mar-2024

    Summary

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    Official Symbol
    lrrfip2provided by ZNC
    Official Full Name
    leucine rich repeat (in FLII) interacting protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-7781
    See related
    Ensembl:ENSDARG00000010400 AllianceGenome:ZFIN:ZDB-GENE-030131-7781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63771; wu:fj34c02; zgc:113956
    Summary
    Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in hatching gland; myotome; pectoral fin; and somite. Orthologous to human LRRFIP2 (LRR binding FLII interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See lrrfip2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (42621205..42674254, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (42495145..42548189, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 83 member Ha Neighboring gene mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene calpain 1, (mu/I) large subunit a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamics of zebrafish fin regeneration using a pulsed SILAC approach. Nolte H, et al. Proteomics, 2015 Feb. PMID 25504979
    2. Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions. Gallagher TL, et al. Dev Biol, 2011 Nov 15. PMID 21925157, Free PMC Article
    3. Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Shkumatava A, et al. Genes Dev, 2009 Feb 15. PMID 19240133, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63771, MGC113956

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat flightless-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034974.4 → NP_001030146.2  leucine-rich repeat flightless-interacting protein 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX936318, EH115383, EH496054, EH577418
      UniProtKB/TrEMBL
      A0A0R4IMS4, A0A8M1N7T5
      Related
      ENSDARP00000135819.1, ENSDART00000169083.2
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 354
      DUF2051; Double stranded RNA binding protein (DUF2051)

    2. NM_199479.3 → NP_955773.1  leucine-rich repeat flightless-interacting protein 2 isoform 2

      See identical proteins and their annotated locations for NP_955773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      BX936318, EH115383, EH496054, EH577418
      UniProtKB/TrEMBL
      Q6PGV0, Q6TEN2
      Related
      ENSDARP00000090511.4, ENSDART00000099738.6
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 330
      DUF2051; Double stranded RNA binding protein (DUF2051)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      42621205..42674254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169517.4 → XP_005169574.1  leucine-rich repeat flightless-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BGT5
      Conserved Domains (1) summary
      pfam09738
      Location:395 → 676
      DUF2051; Double stranded RNA binding protein (DUF2051)

    2. XM_017358705.2 → XP_017214194.1  leucine-rich repeat flightless-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8M6Z935

    3. XM_021480532.1 → XP_021336207.1  leucine-rich repeat flightless-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PXP5
      Conserved Domains (2) summary
      pfam04111
      Location:625 → 720
      APG6; Autophagy protein Apg6
      pfam09738
      Location:395 → 645
      LRRFIP; LRRFIP family

    4. XM_021480533.1 → XP_021336208.1  leucine-rich repeat flightless-interacting protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q9K7
      Conserved Domains (2) summary
      pfam09738
      Location:344 → 625
      LRRFIP; LRRFIP family
      cl26309
      Location:428 → 700
      MscS_TM; Mechanosensitive ion channel inner membrane domain 1

    5. XM_021480534.1 → XP_021336209.1  leucine-rich repeat flightless-interacting protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8M9QF96
      Conserved Domains (2) summary
      pfam04111
      Location:601 → 696
      APG6; Autophagy protein Apg6
      pfam09738
      Location:317 → 621
      LRRFIP; LRRFIP family

    6. XM_005169520.4 → XP_005169577.1  leucine-rich repeat flightless-interacting protein 2 isoform X6

      UniProtKB/TrEMBL
      A0A8M2BGW9
      Conserved Domains (3) summary
      pfam09738
      Location:395 → 611
      DUF2051; Double stranded RNA binding protein (DUF2051)
      pfam12777
      Location:574 → 659
      MT; Microtubule-binding stalk of dynein motor
      cl23765
      Location:379 → 475
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    7. XM_017358706.2 → XP_017214195.1  leucine-rich repeat flightless-interacting protein 2 isoform X7

      UniProtKB/TrEMBL
      A0A8M6Z279

    8. XM_021480535.1 → XP_021336210.1  leucine-rich repeat flightless-interacting protein 2 isoform X8

      UniProtKB/TrEMBL
      A0A8M9QNB1
      Conserved Domains (2) summary
      pfam09738
      Location:279 → 560
      LRRFIP; LRRFIP family
      cl26309
      Location:363 → 635
      MscS_TM; Mechanosensitive ion channel inner membrane domain 1

    9. XM_005169523.4 → XP_005169580.1  leucine-rich repeat flightless-interacting protein 2 isoform X9

      UniProtKB/TrEMBL
      A0A8M2BGV2
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 419
      DUF2051; Double stranded RNA binding protein (DUF2051)

    10. XM_005169524.4 → XP_005169581.1  leucine-rich repeat flightless-interacting protein 2 isoform X10

      UniProtKB/TrEMBL
      A0A8M2BHE2
      Conserved Domains (1) summary
      pfam09738
      Location:50 → 395
      DUF2051; Double stranded RNA binding protein (DUF2051)

    11. XM_021480536.1 → XP_021336211.1  leucine-rich repeat flightless-interacting protein 2 isoform X11

      UniProtKB/TrEMBL
      A0A8M9QJK5
      Conserved Domains (2) summary
      pfam04111
      Location:368 → 463
      APG6; Autophagy protein Apg6
      pfam09738
      Location:50 → 388
      LRRFIP; LRRFIP family

    12. XM_021480537.1 → XP_021336212.1  leucine-rich repeat flightless-interacting protein 2 isoform X12

      UniProtKB/TrEMBL
      A0A8M9PXQ2
      Conserved Domains (2) summary
      pfam04111
      Location:344 → 439
      APG6; Autophagy protein Apg6
      pfam09738
      Location:50 → 364
      LRRFIP; LRRFIP family
    Nucleotide Protein Strain
    Heading Accession and Version

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