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    Rims1 regulating synaptic membrane exocytosis 1 [ Mus musculus (house mouse) ]

    Gene ID: 116837, updated on 12-May-2024

    Summary

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    Official Symbol
    Rims1provided by MGI
    Official Full Name
    regulating synaptic membrane exocytosis 1provided by MGI
    Primary source
    MGI:MGI:2152971
    See related
    Ensembl:ENSMUSG00000041670 AllianceGenome:MGI:2152971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rim; RIM1; RIM1a; Serg1; Rab3ip1; RIM1alpha; C030033M19Rik
    Summary
    Enables transmembrane transporter binding activity. A structural constituent of presynaptic active zone. Involved in neurotransmitter secretion; positive regulation of gene expression; and regulation of nervous system process. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; regulation of long-term neuronal synaptic plasticity; and regulation of membrane potential. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in cone-rod dystrophy 7. Orthologous to human RIMS1 (regulating synaptic membrane exocytosis 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 23.6), frontal lobe adult (RPKM 17.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rims1 in Genome Data Viewer
    Location:
    1 A5; 1 8.54 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (22356196..22845239, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (22285972..22806158, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily Q, member 5 Neighboring gene STARR-seq mESC enhancer starr_00411 Neighboring gene STARR-seq mESC enhancer starr_00412 Neighboring gene predicted gene, 53539 Neighboring gene STARR-seq mESC enhancer starr_00414 Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00415 Neighboring gene STARR-seq mESC enhancer starr_00416 Neighboring gene STARR-seq mESC enhancer starr_00417 Neighboring gene STARR-seq mESC enhancer starr_00419 Neighboring gene STARR-seq mESC enhancer starr_00422 Neighboring gene STARR-seq mESC enhancer starr_00423 Neighboring gene STARR-seq mESC enhancer starr_00424 Neighboring gene predicted gene 7759 Neighboring gene predicted gene 7761

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ultrastructural analysis of wild-type and RIM1α knockout active zones in a large cortical synapse. Lichter K, et al. Cell Rep, 2022 Sep 20. PMID 36130490
    2. Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons. Wang J, et al. Nat Commun, 2018 Jun 11. PMID 29891949, Free PMC Article
    3. Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres. Kintscher M, et al. Nat Commun, 2013. PMID 23999086
    4. Cryo-electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering. Fernández-Busnadiego R, et al. J Cell Biol, 2013 May 27. PMID 23712261, Free PMC Article
    5. Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation. Yang Y, et al. J Neurosci, 2010 Feb 17. PMID 20164339, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cAMP-EPAC-PKCepsilon-RIM1alpha signaling regulates presynaptic long-term potentiation and motor learning.
      Title: cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning.
    2. Here, the authors identify an essential role for the active zone protein RIM in stimulated somatodendritic dopamine release in the midbrain. In mice in which RIMs are selectively removed from dopamine neurons, action potentials failed to evoke significant somatodendritic release detected via D2 receptor-mediated currents.
      Title: RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain.
    3. Conditional deletion of presynaptic proteins RIM1alphabeta (RIM1) from excitatory cortical neurons impairs corticostriatal synaptic transmission in the dorsolateral striatum. RIM1-dependent processes help to promote the refinement of skilled actions, constrain goal-directed behaviors, and support the learning and use of habits.
      Title: Active Zone Proteins RIM1αβ Are Required for Normal Corticostriatal Transmission and Action Control.
    4. RIM C2B domains are constitutive PIP2-binding molecules that couple mechanisms for synaptic vesical priming.
      Title: RIM C(2)B Domains Target Presynaptic Active Zone Functions to PIP(2)-Containing Membranes.
    5. eye-specific segregation in the dLGN and topographic refinement of ipsilateral axons in the SC and the dLGN, are impaired in RIM1/2 conditional knock-out (Rim-cDKO) mice
      Title: RIM1/2 in retinal ganglion cells are required for the refinement of ipsilateral axons and eye-specific segregation.
    6. Postsynaptic RIM1 in hippocampal CA1 region is required for basal NMDAR-, but not AMPA receptor (AMPAR)-, mediated synaptic responses, and contributes to synaptic plasticity and hippocampus-dependent memory. Moreover, RIM1 levels in hippocampal neurons influence both the constitutive and regulated NMDAR trafficking, without affecting constitutive AMPAR trafficking.
      Title: Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons.
    7. Here, the authors show that exophilin-8 accumulates granules in the cortical F-actin network not by direct interaction with myosin-Va, but by indirect interaction with a specific form of myosin-VIIa through its previously unknown binding partner, RIM-BP2.
      Title: Exophilin-8 assembles secretory granules for exocytosis in the actin cortex via interaction with RIM-BP2 and myosin-VIIa.
    8. RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions.
      Title: How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
    9. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47.
      Title: C-terminal splice variants of P/Q-type Ca(2+) channel Ca(V)2.1 α(1) subunits are differentially regulated by Rab3-interacting molecule proteins.
    10. The function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect modulation of the channel.
      Title: RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0340

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in acrosomal vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of inhibitory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of inhibitory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic vesicle priming ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in presynaptic dense core vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic dense core vesicle exocytosis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in presynaptic dense core vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spontaneous neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic vesicle docking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoskeleton of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extrinsic component of presynaptic active zone membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extrinsic component of presynaptic active zone membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in inhibitory synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in presynaptic active zone cytoplasmic component ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulating synaptic membrane exocytosis protein 1
    Names
    Rab3 effector
    Rab3 interacting protein 1
    rab3-interacting molecule 1
    regulating synaptic membrane exocytosis 1 beta
    synaptic exocytosis regulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012623.4 → NP_001012641.2  regulating synaptic membrane exocytosis protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1383 → 1528
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:755 → 881
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:617 → 702
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    2. NM_001012624.4 → NP_001012642.2  regulating synaptic membrane exocytosis protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1359 → 1504
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:755 → 881
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:617 → 702
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    3. NM_001012625.4 → NP_001012643.2  regulating synaptic membrane exocytosis protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
      UniProtKB/TrEMBL
      F6TZK4, F6VBV0
      Related
      ENSMUSP00000080259.8, ENSMUST00000081544.14
      Conserved Domains (6) summary
      cd04028
      Location:1308 → 1453
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:755 → 881
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:884 → 1070
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:617 → 702
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    4. NM_053270.4 → NP_444500.2  regulating synaptic membrane exocytosis protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
      UniProtKB/TrEMBL
      E9PWP6, F6VBV0
      Related
      ENSMUSP00000095417.8, ENSMUST00000097808.9
      Conserved Domains (5) summary
      cd04028
      Location:1472 → 1617
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:755 → 881
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:617 → 702
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    5. NM_183018.5 → NP_898839.3  regulating synaptic membrane exocytosis protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117188, AC125522, AC130211, AC147129, AC174648, AEKQ02040097, AEKQ02040098
      UniProtKB/TrEMBL
      F6VBV0, F6Y0S3
      Related
      ENSMUSP00000110928.4, ENSMUST00000115273.10
      Conserved Domains (6) summary
      cd04028
      Location:1444 → 1589
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:755 → 881
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:939 → 1148
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:617 → 702
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:214 → 316
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 209
      FYVE_like_SF; FYVE domain like superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      22356196..22845239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154438.1 → XP_036010331.1  regulating synaptic membrane exocytosis protein 1 isoform X41

      Conserved Domains (4) summary
      cd04028
      Location:736 → 881
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:403 → 612
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. XM_036154447.1 → XP_036010340.1  regulating synaptic membrane exocytosis protein 1 isoform X42

      Conserved Domains (4) summary
      cd04028
      Location:703 → 848
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:403 → 604
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    3. XM_036154452.1 → XP_036010345.1  regulating synaptic membrane exocytosis protein 1 isoform X43

      UniProtKB/TrEMBL
      Q7TPL9
      Related
      ENSMUSP00000131808.2, ENSMUST00000164877.8
      Conserved Domains (1) summary
      cd04028
      Location:50 → 195
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

    4. XM_036154458.1 → XP_036010351.1  regulating synaptic membrane exocytosis protein 1 isoform X44

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (7) summary
      cd04028
      Location:1250 → 1395
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:705 → 831
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:880 → 1179
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:567 → 652
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:164 → 266
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:104 → 159
      FYVE_like_SF; FYVE domain like superfamily
      cl22851
      Location:26 → 153
      PHD_SF; PHD finger superfamily

    5. XM_036154343.1 → XP_036010236.1  regulating synaptic membrane exocytosis protein 1 isoform X28

      Conserved Domains (5) summary
      cd04028
      Location:1147 → 1292
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    6. XM_036154326.1 → XP_036010219.1  regulating synaptic membrane exocytosis protein 1 isoform X27

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1198 → 1343
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    7. XM_036154314.1 → XP_036010207.1  regulating synaptic membrane exocytosis protein 1 isoform X26

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1222 → 1367
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    8. XM_036154306.1 → XP_036010199.1  regulating synaptic membrane exocytosis protein 1 isoform X25

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1250 → 1395
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:895 → 1164
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    9. XM_036154248.1 → XP_036010141.1  regulating synaptic membrane exocytosis protein 1 isoform X21

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1311 → 1456
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:941 → 1240
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    10. XM_036153963.1 → XP_036009856.1  regulating synaptic membrane exocytosis protein 1 isoform X1

      UniProtKB/TrEMBL
      F6VBV0
      Related
      ENSMUSP00000095418.5, ENSMUST00000097809.11
      Conserved Domains (5) summary
      cd04028
      Location:1483 → 1628
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    11. XM_036154141.1 → XP_036010034.1  regulating synaptic membrane exocytosis protein 1 isoform X12

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1422 → 1567
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:705 → 831
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:567 → 652
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:164 → 266
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:104 → 159
      FYVE_like_SF; FYVE domain like superfamily
      cl22851
      Location:26 → 153
      PHD_SF; PHD finger superfamily

    12. XM_036154130.1 → XP_036010023.1  regulating synaptic membrane exocytosis protein 1 isoform X11

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1433 → 1578
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:716 → 842
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:578 → 663
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:175 → 277
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:104 → 170
      FYVE_like_SF; FYVE domain like superfamily
      cl22851
      Location:26 → 164
      PHD_SF; PHD finger superfamily

    13. XM_036154297.1 → XP_036010190.1  regulating synaptic membrane exocytosis protein 1 isoform X24

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1291 → 1436
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:574 → 700
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:436 → 521
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:33 → 135
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:1 → 28
      FYVE_like_SF; FYVE domain like superfamily

    14. XM_036154075.1 → XP_036009968.1  regulating synaptic membrane exocytosis protein 1 isoform X8

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1456 → 1601
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:739 → 865
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:601 → 686
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:198 → 300
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:127 → 193
      FYVE_like_SF; FYVE domain like superfamily

    15. XM_036154043.1 → XP_036009936.1  regulating synaptic membrane exocytosis protein 1 isoform X6

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1459 → 1604
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:742 → 868
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:604 → 689
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:201 → 303
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:130 → 196
      FYVE_like_SF; FYVE domain like superfamily

    16. XM_036154235.1 → XP_036010128.1  regulating synaptic membrane exocytosis protein 1 isoform X19

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1336 → 1481
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:732 → 858
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:594 → 679
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:191 → 293
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:131 → 186
      FYVE_like_SF; FYVE domain like superfamily

    17. XM_036154101.1 → XP_036009994.1  regulating synaptic membrane exocytosis protein 1 isoform X10

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1449 → 1594
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:732 → 858
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:594 → 679
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:191 → 293
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:131 → 186
      FYVE_like_SF; FYVE domain like superfamily

    18. XM_036154015.1 → XP_036009908.1  regulating synaptic membrane exocytosis protein 1 isoform X4

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1460 → 1605
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:743 → 869
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:605 → 690
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:202 → 304
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:131 → 197
      FYVE_like_SF; FYVE domain like superfamily

    19. XM_036154285.1 → XP_036010178.1  regulating synaptic membrane exocytosis protein 1 isoform X24

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1291 → 1436
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:574 → 700
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:436 → 521
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:33 → 135
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:1 → 28
      FYVE_like_SF; FYVE domain like superfamily

    20. XM_036154267.1 → XP_036010160.1  regulating synaptic membrane exocytosis protein 1 isoform X23

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1295 → 1440
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    21. XM_036154055.1 → XP_036009948.1  regulating synaptic membrane exocytosis protein 1 isoform X7

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1459 → 1604
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    22. XM_036154256.1 → XP_036010149.1  regulating synaptic membrane exocytosis protein 1 isoform X22

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1310 → 1455
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:895 → 1081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    23. XM_036154243.1 → XP_036010136.1  regulating synaptic membrane exocytosis protein 1 isoform X20

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1319 → 1464
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:895 → 1081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    24. XM_036153980.1 → XP_036009873.1  regulating synaptic membrane exocytosis protein 1 isoform X3

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1462 → 1607
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01642
      Location:982 → 1096
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    25. XM_036154227.1 → XP_036010120.1  regulating synaptic membrane exocytosis protein 1 isoform X18

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1361 → 1506
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    26. XM_036154205.1 → XP_036010098.1  regulating synaptic membrane exocytosis protein 1 isoform X17

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1370 → 1515
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    27. XM_036154195.1 → XP_036010088.1  regulating synaptic membrane exocytosis protein 1 isoform X16

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1385 → 1530
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    28. XM_036154178.1 → XP_036010071.1  regulating synaptic membrane exocytosis protein 1 isoform X15

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1394 → 1539
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    29. XM_036154086.1 → XP_036009979.1  regulating synaptic membrane exocytosis protein 1 isoform X9

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1455 → 1600
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:950 → 1159
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    30. XM_036154160.1 → XP_036010053.1  regulating synaptic membrane exocytosis protein 1 isoform X14

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1398 → 1543
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:950 → 1139
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    31. XM_036154026.1 → XP_036009919.1  regulating synaptic membrane exocytosis protein 1 isoform X5

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1459 → 1604
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:950 → 1163
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    32. XM_036154151.1 → XP_036010044.1  regulating synaptic membrane exocytosis protein 1 isoform X13

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (6) summary
      cd04028
      Location:1422 → 1567
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:977 → 1184
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    33. XM_036153973.1 → XP_036009866.1  regulating synaptic membrane exocytosis protein 1 isoform X2

      UniProtKB/TrEMBL
      F6VBV0
      Conserved Domains (5) summary
      cd04028
      Location:1474 → 1619
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:766 → 892
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:628 → 713
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam04642
      Location:225 → 327
      DUF601; Protein of unknown function, DUF601
      cl28890
      Location:154 → 220
      FYVE_like_SF; FYVE domain like superfamily

    34. XM_036154361.1 → XP_036010254.1  regulating synaptic membrane exocytosis protein 1 isoform X29

      Conserved Domains (4) summary
      cd04028
      Location:936 → 1081
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:403 → 589
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    35. XM_036154371.1 → XP_036010264.1  regulating synaptic membrane exocytosis protein 1 isoform X30

      Conserved Domains (4) summary
      cd04028
      Location:908 → 1053
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:403 → 612
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    36. XM_036154396.1 → XP_036010289.1  regulating synaptic membrane exocytosis protein 1 isoform X32

      Conserved Domains (4) summary
      cd04028
      Location:866 → 1011
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:430 → 637
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    37. XM_036154410.1 → XP_036010303.1  regulating synaptic membrane exocytosis protein 1 isoform X35

      Conserved Domains (4) summary
      cd04028
      Location:830 → 975
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:348 → 572
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    38. XM_036154384.1 → XP_036010277.1  regulating synaptic membrane exocytosis protein 1 isoform X31

      Conserved Domains (4) summary
      cd04028
      Location:875 → 1020
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:348 → 617
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    39. XM_036154411.1 → XP_036010304.1  regulating synaptic membrane exocytosis protein 1 isoform X36

      Conserved Domains (4) summary
      cd04028
      Location:826 → 971
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      TIGR01642
      Location:435 → 541
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

    40. XM_036154408.1 → XP_036010301.1  regulating synaptic membrane exocytosis protein 1 isoform X34

      Conserved Domains (4) summary
      cd04028
      Location:847 → 992
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:403 → 588
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    41. XM_036154426.1 → XP_036010319.1  regulating synaptic membrane exocytosis protein 1 isoform X38

      Conserved Domains (3) summary
      cd04028
      Location:814 → 959
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    42. XM_036154414.1 → XP_036010307.1  regulating synaptic membrane exocytosis protein 1 isoform X37

      Conserved Domains (3) summary
      cd04028
      Location:823 → 968
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    43. XM_036154433.1 → XP_036010326.1  regulating synaptic membrane exocytosis protein 1 isoform X40

      Conserved Domains (4) summary
      cd04028
      Location:763 → 908
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:348 → 560
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    44. XM_036154432.1 → XP_036010325.1  regulating synaptic membrane exocytosis protein 1 isoform X39

      UniProtKB/TrEMBL
      Q3UYL2
      Conserved Domains (4) summary
      cd04028
      Location:772 → 917
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:219 → 345
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:348 → 560
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:81 → 166
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    45. XM_036154403.1 → XP_036010296.1  regulating synaptic membrane exocytosis protein 1 isoform X33

      Conserved Domains (4) summary
      cd04028
      Location:852 → 997
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:135 → 261
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:319 → 505
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:1 → 82
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NE5.2 GenPept UniProtKB/Swiss-Prot:Q99NE5

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