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    CAP1 Cap1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853862, updated on 5-May-2024

    Summary

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    Gene symbol
    CAP1
    Gene description
    Cap1p
    Primary source
    SGD:S000001490
    Locus tag
    YKL007W
    See related
    AllianceGenome:SGD:S000001490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables actin filament binding activity. Involved in barbed-end actin filament capping. Located in actin cortical patch and cellular bud tip. Part of F-actin capping protein complex and incipient cellular bud site. Orthologous to several human genes including CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) and CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (429302..430108)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mrt4p Neighboring gene sphingosine N-acyltransferase LAC1 Neighboring gene Sft1p Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence of a 7.8 kb segment on the left arm of yeast chromosome XI reveals four open reading frames, including the CAP1 gene, an intron-containing gene and a gene encoding a homolog to the mammalian UOG-1 gene. Boyer J, et al. Yeast, 1993 Mar. PMID 8488728
    2. Capping protein binding to actin in yeast: biochemical mechanism and physiological relevance. Kim K, et al. J Cell Biol, 2004 Feb 16. PMID 14769858, Free PMC Article
    3. Effects of null mutations and overexpression of capping protein on morphogenesis, actin distribution and polarized secretion in yeast. Amatruda JF, et al. J Cell Biol, 1992 Dec. PMID 1447293, Free PMC Article
    4. Purification, characterization, and immunofluorescence localization of Saccharomyces cerevisiae capping protein. Amatruda JF, et al. J Cell Biol, 1992 Jun. PMID 1315784, Free PMC Article
    5. AP1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily. Alarco AM, et al. J Biol Chem, 1997 Aug 1. PMID 9235926

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structural basis of actin monomer re-charging by CAP1 protein has been reported.
      Title: Structural basis of actin monomer re-charging by cyclase-associated protein.
    2. a novel model for how sequential interactions between actin monomers, twinfilin, CP, and actin filaments promote cytoskeletal dynamics
      Title: Biological role and structural mechanism of twinfilin-capping protein interaction.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of F-actin capping protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of F-actin capping protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of F-actin capping protein complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    located_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cap1p
    NP_012918.1
    • Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      429302..430108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179573.1 → NP_012918.1  TPA: Cap1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXS9, P28495
      UniProtKB/TrEMBL
      A0A6L1BCK9, A6ZZV8, B3LR77, B5VME6, C7GRG6, C8ZCF9, G2WI24, N1P803
      Conserved Domains (1) summary
      pfam01267
      Location:10 → 265
      F-actin_cap_A; F-actin capping protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28495.1

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