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    NEDD4 NEDD4 E3 ubiquitin protein ligase [ Bos taurus (cattle) ]

    Gene ID: 507781, updated on 5-Mar-2024

    Summary

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    Official Symbol
    NEDD4provided by VGNC
    Official Full Name
    NEDD4 E3 ubiquitin protein ligaseprovided by VGNC
    Primary source
    VGNC:VGNC:55128
    See related
    BGD:BT23189; Ensembl:ENSBTAG00000013793
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 10
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (54426277..54570735)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene tigger transposable element-derived protein 1-like Neighboring gene regulatory factor X7 Neighboring gene induced myeloid leukemia cell differentiation protein Mcl-1 homolog Neighboring gene uncharacterized LOC104973164 Neighboring gene protogenin Neighboring gene pygopus family PHD finger 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sodium channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of sodium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuromuscular junction development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dendrite morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase NEDD4
    Names
    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    XP_003586620.1
    XP_010807618.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      54426277..54570735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003586572.6 → XP_003586620.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

      See identical proteins and their annotated locations for XP_003586620.1

      UniProtKB/TrEMBL
      A0A3Q1LT33, A0A3Q1NEU5
      Related
      ENSBTAP00000060537.1, ENSBTAT00000073729.2
      Conserved Domains (5) summary
      cd04033
      Location:20 → 151
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:475 → 507
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:568 → 897
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:544 → 898
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:424 → 453
      WW; WW domain

    2. XM_010809316.4 → XP_010807618.1  E3 ubiquitin-protein ligase NEDD4 isoform X1

      See identical proteins and their annotated locations for XP_010807618.1

      UniProtKB/TrEMBL
      F1MJ10
      Related
      ENSBTAP00000018331.6, ENSBTAT00000018331.7
      Conserved Domains (5) summary
      smart00456
      Location:895 → 927
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:988 → 1317
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:964 → 1318
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:844 → 873
      WW; WW domain
      cl14603
      Location:518 → 571
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version

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