Irak2 interleukin-1 receptor-associated kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irak2provided by MGI
Official Full Name: interleukin-1 receptor-associated kinase 2provided by MGI
Primary source: MGI:MGI:2429603
See related: Ensembl:ENSMUSG00000060477 AllianceGenome:MGI:2429603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: IRAK-2; 6330415L08Rik
Summary: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Acts upstream of or within lipopolysaccharide-mediated signaling pathway; negative regulation of DNA-binding transcription factor activity; and positive regulation of NF-kappaB transcription factor activity. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in several structures, including Peyer's patch; brain; genitourinary system; respiratory system; and thymus. Orthologous to human IRAK2 (interleukin 1 receptor associated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in small intestine adult (RPKM 18.9), large intestine adult (RPKM 18.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 52.82 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (113615428..113671987)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (113638467..113695026)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid beta-oxidation to alleviate diabetic cardiomyopathy.
Title: Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy.
IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models.
Title: IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models.
lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p.
Title: lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p.
The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination and optimal TLR signaling.
Title: The extreme C-terminus of IRAK2 assures full TRAF6 ubiquitination and optimal TLR signaling.
IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
Title: IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
miR-497 can partially negatively regulate the activation of IRAK2-NF-kappaB pathway in LPS-induced inflammatory responses
Title: miR-497a-5p attenuates lipopolysaccharide-induced inflammatory injury by targeting IRAK2.
In summary, lipopolysaccharide activates a nuclear function of IRAK2 that facilitates the assembly of nuclear export machinery to export selected inflammatory mRNAs to the cytoplasm for translation.
Title: IRAK2 directs stimulus-dependent nuclear export of inflammatory mRNAs.
These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 pathway.
Title: Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling.
Our results establish that the IRAK2-TRAF6 interaction is rate limiting for the late, but not the early phase of cytokine production in bone marrow-derived macrophages and plasmacytoid dendritic cells
Title: Two phases of inflammatory mediator production defined by the study of IRAK2 and IRAK1 knock-in mice.
IRAK2 plays a key role in the TLR9-mediated transcriptional regulation of Irak-m expression by sustaining activation of PKD1 and NF-kappaB
Title: Interleukin-1 receptor-associated kinase 2- and protein kinase D1-dependent regulation of IRAK-monocyte expression by CpG DNA.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

AI649099 (e-PCR)
- UniSTS:179439

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Toll signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-1-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of apoptotic process	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-1 receptor-associated kinase-like 2

Names: interleukin-1 receptor-associated kinase 2c; mu-IRAK-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113553.1 → NP_001107025.1 interleukin-1 receptor-associated kinase-like 2 isoform b

See identical proteins and their annotated locations for NP_001107025.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is smaller compared to isoform a.

Source sequence(s)

AK078062, AY162379, BY110939, CJ212338

Consensus CDS

CCDS51873.1

UniProtKB/Swiss-Prot

Q8CFA1

Related

ENSMUSP00000086416.5, ENSMUST00000089022.9

Conserved Domains (3) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

pfam00069
Location:160 → 424

Pkinase; Protein kinase domain

cl21453
Location:166 → 454

PKc_like; Protein Kinases, catalytic domain
NM_172161.4 → NP_751893.3 interleukin-1 receptor-associated kinase-like 2 isoform a

See identical proteins and their annotated locations for NP_751893.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and enodes the longer isoform (a).

Source sequence(s)

AK078062, AY162378, BY110939, CJ212338

Consensus CDS

CCDS20430.1

UniProtKB/Swiss-Prot

Q3U3K2, Q3U7F5, Q3UFX2, Q5U404, Q6YBR8, Q6YBR9, Q6YBS0, Q6YBS1, Q8C5M0, Q8CC82, Q8CEA0, Q8CFA1

Related

ENSMUSP00000055073.8, ENSMUST00000059286.14

Conserved Domains (3) summary

cd08795
Location:3 → 91

Death_IRAK2; Death domain of Interleukin 1 Receptor Associated Kinase-2

pfam00069
Location:208 → 472

Pkinase; Protein kinase domain

cl21453
Location:214 → 502

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

113615428..113671987

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505325.5 → XP_006505388.1 interleukin-1 receptor-associated kinase-like 2 isoform X1

UniProtKB/Swiss-Prot

Q8CFA1

Conserved Domains (1) summary

cl21453
Location:71 → 359

PKc_like; Protein Kinases, catalytic domain