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    Rab27b RAB27B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84590, updated on 3-Apr-2024

    Summary

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    Symbol
    Rab27bprovided by RGD
    Full Name
    RAB27B, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:620114
    See related
    Ensembl:ENSRNOG00000012176 AllianceGenome:RGD:620114
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and myosin V binding activity. Involved in anterograde axonal protein transport; regulation of exocytosis; and synaptic vesicle endocytosis. Located in apical plasma membrane and zymogen granule membrane. Is anchored component of synaptic vesicle membrane. Orthologous to human RAB27B (RAB27B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 111.5), Spleen (RPKM 81.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab27b in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (65870230..66069597, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (63597554..63794124, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (68486006..68644595, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482985 Neighboring gene coiled-coil domain containing 68 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC120098183

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells. Gallo LI, et al. Am J Physiol Cell Physiol, 2018 Mar 1. PMID 29167152, Free PMC Article
    2. Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes. Shen YT, et al. Neurosci Bull, 2016 Aug. PMID 27325508, Free PMC Article
    3. Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Chen X, et al. Biochem Biophys Res Commun, 2004 Oct 29. PMID 15451418
    4. NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages. Ejlerskov P, et al. J Biol Chem, 2012 Feb 10. PMID 22157766, Free PMC Article
    5. Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. Arimura N, et al. Dev Cell, 2009 May. PMID 19460344

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RAB27B regulates discoidal- and/or fusiform-shaped vesicle exocytosis in bladder umbrella cells.
      Title: RAB27B requirement for stretch-induced exocytosis in bladder umbrella cells.
    2. The data of this study suggested that Rab27b is involved in myelin biogenesis by regulating PLP transport from late endosomes/lysosomes to the cell membrane in oligodendrocytes.
      Title: Rab27b is Involved in Lysosomal Exocytosis and Proteolipid Protein Trafficking in Oligodendrocytes.
    3. cyt b(558) depends on clathrin for internalization, and in activated macrophages NADPH oxidase occupies a Rab27A/B-regulated secretory compartment
      Title: NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages.
    4. Selective modulation of the GTP/GDP switch mechanism of Rab27b impairs synaptic vesicle recycling and suggests that Rab27b, in concert with Rab3a, is involved in synaptic vesicle exocytosis.
      Title: Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis.
    5. Study shows that the Slp1/Rab27B/CRMP-2 complex directly links TrkB to Kinesin-1, and that this association is required for the anterograde transport of TrkB-containing vesicles in axons.
      Title: Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.
    6. the Rab27B-Slac2-c complex is an important constituent of secretory granule exocytosis in parotid acinar cells
      Title: The small GTPase Rab27B regulates amylase release from rat parotid acinar cells.
    7. These results demonstrate that Rab27b is present on ZGs and plays an important role in regulating acinar exocytosis.
      Title: Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GDP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables myosin V binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multivesicular body sorting pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in exocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in melanosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in melanosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in multivesicular body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in zymogen granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras-related protein Rab-27B
    NP_445911.1
    XP_006254992.1
    XP_017456535.1
    XP_038953121.1
    XP_038953122.1
    XP_038953123.1
    XP_038953127.1
    XP_063133705.1
    XP_063133706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053459.1 → NP_445911.1  ras-related protein Rab-27B

      See identical proteins and their annotated locations for NP_445911.1

      Status: PROVISIONAL

      Source sequence(s)
      AF325693
      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Related
      ENSRNOP00000095120.1, ENSRNOT00000106463.1
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      65870230..66069597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097195.2 → XP_038953123.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    2. XM_063277636.1 → XP_063133706.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5

    3. XM_063277635.1 → XP_063133705.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5

    4. XM_006254930.5 → XP_006254992.1  ras-related protein Rab-27B isoform X1

      See identical proteins and their annotated locations for XP_006254992.1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    5. XM_039097193.2 → XP_038953121.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    6. XM_039097194.2 → XP_038953122.1  ras-related protein Rab-27B isoform X1

      UniProtKB/Swiss-Prot
      Q99P74
      UniProtKB/TrEMBL
      A6IXZ5
      Conserved Domains (1) summary
      cd04127
      Location:6 → 185
      Rab27A; Rab GTPase family 27a (Rab27a)

    7. XM_017601046.3 → XP_017456535.1  ras-related protein Rab-27B isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q7R9
      Related
      ENSRNOP00000016369.2

    8. XM_039097199.2 → XP_038953127.1  ras-related protein Rab-27B isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99P74.3 GenPept UniProtKB/Swiss-Prot:Q99P74

    Gene LinkOut

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