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RAB27B RAB27B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 5874, updated on 17-Jun-2019

Summary

Official Symbol
RAB27Bprovided by HGNC
Official Full Name
RAB27B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9767
See related
Ensembl:ENSG00000041353 MIM:603869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C25KG
Summary
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]
Expression
Biased expression in stomach (RPKM 15.0), prostate (RPKM 9.9) and 13 other tissues See more
Orthologs

Genomic context

See RAB27B in Genome Data Viewer
Location:
18q21.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (54717842..54895516)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (52385097..52562747)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 2 Neighboring gene dynactin associated protein Neighboring gene ribosomal protein SA pseudogene 57 Neighboring gene coiled-coil domain containing 68 Neighboring gene uncharacterized LOC107985125 Neighboring gene microtubule associated protein 1 light chain 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Deregulation of Rab and Rab Effector Genes in Bladder Cancer, organism-specific biosystem (from WikiPathways)
    Deregulation of Rab and Rab Effector Genes in Bladder Cancer, organism-specific biosystemExample of the Rab27 cluster. The Rab27 cluster is comprised of the two RAB27 isoforms (RAB27A and RAB27B), the GEF MADD, the GAP TBC1D10A and 12 effector proteins
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Platelet degranulation, organism-specific biosystem (from REACTOME)
    Platelet degranulation, organism-specific biosystemPlatelets function as exocytotic cells, secreting a plethora of effector molecules at sites of vascular injury. Platelets contain a number of distinguishable storage granules including alpha granules...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystem (from REACTOME)
    RAB GEFs exchange GTP for GDP on RABs, organism-specific biosystemHuman cells have more than 60 RAB proteins that are key regulators of intracellular membrane trafficking. These small GTPases contribute to trafficking specificity by localizing to the membranes of d...
  • RAB geranylgeranylation, organism-specific biosystem (from REACTOME)
    RAB geranylgeranylation, organism-specific biosystemHuman cells have more than 60 RAB proteins that are involved in trafficking of proteins in the endolysosomal system. These small GTPases contribute to trafficking specificity by localizing to the mem...
  • Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
    Response to elevated platelet cytosolic Ca2+, organism-specific biosystemActivation of phospholipase C enzymes results in the generation of second messengers of the phosphatidylinositol pathway. The events resulting from this pathway are a rise in intracellular calcium an...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
myosin V binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anterograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
melanosome transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
anchored component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
melanosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
melanosome IDA
Inferred from Direct Assay
more info
PubMed 
multivesicular body membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
platelet dense granule membrane TAS
Traceable Author Statement
more info
 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ras-related protein Rab-27B
NP_004154.2
XP_005266790.1
XP_006722581.1
XP_011524433.1
XP_016881402.1
XP_016881403.1
XP_024307000.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004163.4NP_004154.2  ras-related protein Rab-27B

    See identical proteins and their annotated locations for NP_004154.2

    Status: VALIDATED

    Source sequence(s)
    AC098848, AF329499
    Consensus CDS
    CCDS11958.1
    UniProtKB/Swiss-Prot
    O00194
    Related
    ENSP00000262094.4, ENST00000262094.10
    Conserved Domains (1) summary
    cd04127
    Location:6185
    Rab27A; Rab GTPase family 27a (Rab27a)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    54717842..54895516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025913.1XP_016881402.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    O00194
    Conserved Domains (1) summary
    cd04127
    Location:6185
    Rab27A; Rab GTPase family 27a (Rab27a)
  2. XM_017025914.1XP_016881403.1  ras-related protein Rab-27B isoform X1

    UniProtKB/Swiss-Prot
    O00194
    Conserved Domains (1) summary
    cd04127
    Location:6185
    Rab27A; Rab GTPase family 27a (Rab27a)
  3. XM_005266733.1XP_005266790.1  ras-related protein Rab-27B isoform X1

    See identical proteins and their annotated locations for XP_005266790.1

    UniProtKB/Swiss-Prot
    O00194
    Conserved Domains (1) summary
    cd04127
    Location:6185
    Rab27A; Rab GTPase family 27a (Rab27a)
  4. XM_006722518.1XP_006722581.1  ras-related protein Rab-27B isoform X2

    See identical proteins and their annotated locations for XP_006722581.1

    Conserved Domains (2) summary
    smart00174
    Location:12170
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:6156
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_011526131.1XP_011524433.1  ras-related protein Rab-27B isoform X2

    See identical proteins and their annotated locations for XP_011524433.1

    Conserved Domains (2) summary
    smart00174
    Location:12170
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cl21455
    Location:6156
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_024451232.1XP_024307000.1  ras-related protein Rab-27B isoform X1

    Conserved Domains (1) summary
    cd04127
    Location:6185
    Rab27A; Rab GTPase family 27a (Rab27a)

RNA

  1. XR_935245.1 RNA Sequence

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