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    KANK2 KN motif and ankyrin repeat domains 2 [ Bos taurus (cattle) ]

    Gene ID: 767586, updated on 5-Mar-2024

    Summary

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    Official Symbol
    KANK2provided by VGNC
    Official Full Name
    KN motif and ankyrin repeat domains 2provided by VGNC
    Primary source
    VGNC:VGNC:30390
    See related
    Ensembl:ENSBTAG00000009568
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    ANKRD25
    Orthologs
    human mouse all
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    Genomic context

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    See KANK2 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (15601583..15628101, complement)

    Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor Neighboring gene SPC24 component of NDC80 kinetochore complex Neighboring gene dedicator of cytokinesis 6 Neighboring gene angiopoietin like 8 Neighboring gene tetraspanin 16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of vitamin D receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 2
    Names
    Ankyrin repeat domain-containing protein 25
    ankyrin repeat domain 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076531.1 → NP_001069999.1  KN motif and ankyrin repeat domain-containing protein 2

      See identical proteins and their annotated locations for NP_001069999.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115992
      UniProtKB/Swiss-Prot
      Q1LZH7
      Related
      ENSBTAP00000012586.5, ENSBTAT00000012586.6
      Conserved Domains (4) summary
      COG0666
      Location:658 → 813
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:746 → 776
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:750 → 835
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      15601583..15628101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024994638.2 → XP_024850406.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q1LZH7
      Conserved Domains (4) summary
      COG0666
      Location:658 → 813
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:746 → 776
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:750 → 835
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_024994641.2 → XP_024850409.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

      Conserved Domains (4) summary
      cd00204
      Location:664 → 828
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:742 → 772
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:631 → 701
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_024994639.2 → XP_024850407.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q1LZH7
      Conserved Domains (4) summary
      COG0666
      Location:658 → 813
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:746 → 776
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:750 → 835
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_024994640.2 → XP_024850408.1  KN motif and ankyrin repeat domain-containing protein 2 isoform X2

      Conserved Domains (4) summary
      cd00204
      Location:664 → 828
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:742 → 772
      ANK; ANK repeat [structural motif]
      pfam12075
      Location:31 → 69
      KN_motif; KN motif
      pfam12796
      Location:631 → 701
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q1LZH7.1 GenPept UniProtKB/Swiss-Prot:Q1LZH7

    Gene LinkOut

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