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    PRMT5 protein arginine methyltransferase 5 [ Canis lupus familiaris (dog) ]

    Gene ID: 480242, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PRMT5provided by VGNC
    Official Full Name
    protein arginine methyltransferase 5provided by VGNC
    Primary source
    VGNC:VGNC:44998
    See related
    Ensembl:ENSCAFG00845002461
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See PRMT5 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (3356162..3365422, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (3196693..3205933, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (3371200..3380454, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (3047415..3056657, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (3108945..3118202, complement)

    Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene RRAD and GEM like GTPase 2 Neighboring gene uncharacterized LOC111096963 Neighboring gene RNA binding motif protein 23 Neighboring gene transfer RNA arginine (anticodon ACG) Neighboring gene ajuba LIM protein Neighboring gene uncharacterized LOC111096962

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables histone arginine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-arginine N-methylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein arginine N-methyltransferase 5
    XP_022277509.1
    XP_022277510.1
    XP_038338682.1
    XP_038338683.1
    XP_038338684.1
    XP_038338685.1
    XP_038338686.1
    XP_038400103.1
    XP_038400104.1
    XP_038400105.1
    XP_038400106.1
    XP_038400107.1
    XP_038439266.1
    XP_038464224.1
    XP_038464225.1
    XP_038464226.1
    XP_038464227.1
    XP_038464228.1
    XP_038529028.1
    XP_038529029.1
    XP_038529030.1
    XP_038529031.1
    XP_038529032.1
    XP_537366.2
    XP_857529.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051812.1 Reference ROS_Cfam_1.0

      Range
      3356162..3365422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038673101.1 → XP_038529029.1  protein arginine N-methyltransferase 5 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NN99, A0A8C0PPS3, A0A8C0QWZ0, A0A8I3RQT2
      Related
      ENSCAFP00845003643.1, ENSCAFT00845004559.1
      Conserved Domains (3) summary
      pfam05185
      Location:295 → 464
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 290
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:468 → 635
      PRMT5_C; PRMT5 oligomerization domain

    2. XM_038673100.1 → XP_038529028.1  protein arginine N-methyltransferase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NN99
      Conserved Domains (3) summary
      pfam05185
      Location:305 → 474
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 300
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:478 → 645
      PRMT5_C; PRMT5 oligomerization domain

    3. XM_038673104.1 → XP_038529032.1  protein arginine N-methyltransferase 5 isoform X5

      UniProtKB/TrEMBL
      A0A8C0NQU7
      Conserved Domains (3) summary
      pfam05185
      Location:189 → 358
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:1 → 184
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:362 → 529
      PRMT5_C; PRMT5 oligomerization domain

    4. XM_038673102.1 → XP_038529030.1  protein arginine N-methyltransferase 5 isoform X3

      UniProtKB/TrEMBL
      A0A8C0NQU7
      Conserved Domains (3) summary
      pfam05185
      Location:288 → 457
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 283
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:461 → 628
      PRMT5_C; PRMT5 oligomerization domain

    5. XM_038673103.1 → XP_038529031.1  protein arginine N-methyltransferase 5 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NQU7, A0A8C0RV99, A0A8I3MM19
      Related
      ENSCAFP00845003687.1, ENSCAFT00845004614.1
      Conserved Domains (3) summary
      pfam05185
      Location:278 → 447
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 273
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:451 → 618
      PRMT5_C; PRMT5 oligomerization domain

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049268.1 Alternate UMICH_Zoey_3.1

      Range
      3047415..3056657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038482755.1 → XP_038338683.1  protein arginine N-methyltransferase 5 isoform X2

      Conserved Domains (3) summary
      pfam05185
      Location:295 → 464
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 290
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:468 → 635
      PRMT5_C; PRMT5 oligomerization domain

    2. XM_038482754.1 → XP_038338682.1  protein arginine N-methyltransferase 5 isoform X1

      Conserved Domains (3) summary
      pfam05185
      Location:305 → 474
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 300
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:478 → 645
      PRMT5_C; PRMT5 oligomerization domain

    3. XM_038482758.1 → XP_038338686.1  protein arginine N-methyltransferase 5 isoform X5

      Conserved Domains (3) summary
      pfam05185
      Location:189 → 358
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:1 → 184
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:362 → 529
      PRMT5_C; PRMT5 oligomerization domain

    4. XM_038482756.1 → XP_038338684.1  protein arginine N-methyltransferase 5 isoform X3

      Conserved Domains (3) summary
      pfam05185
      Location:288 → 457
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 283
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:461 → 628
      PRMT5_C; PRMT5 oligomerization domain

    5. XM_038482757.1 → XP_038338685.1  protein arginine N-methyltransferase 5 isoform X4

      Conserved Domains (3) summary
      pfam05185
      Location:278 → 447
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 273
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:451 → 618
      PRMT5_C; PRMT5 oligomerization domain

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

      Range
      3108945..3118202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038608297.1 → XP_038464225.1  protein arginine N-methyltransferase 5 isoform X2

      Conserved Domains (3) summary
      pfam05185
      Location:295 → 464
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 290
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:468 → 635
      PRMT5_C; PRMT5 oligomerization domain

    2. XM_038608296.1 → XP_038464224.1  protein arginine N-methyltransferase 5 isoform X1

      Conserved Domains (3) summary
      pfam05185
      Location:305 → 474
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 300
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:478 → 645
      PRMT5_C; PRMT5 oligomerization domain

    3. XM_038608300.1 → XP_038464228.1  protein arginine N-methyltransferase 5 isoform X5

      Conserved Domains (3) summary
      pfam05185
      Location:189 → 358
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:1 → 184
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:362 → 529
      PRMT5_C; PRMT5 oligomerization domain

    4. XM_038608298.1 → XP_038464226.1  protein arginine N-methyltransferase 5 isoform X3

      Conserved Domains (3) summary
      pfam05185
      Location:288 → 457
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 283
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:461 → 628
      PRMT5_C; PRMT5 oligomerization domain

    5. XM_038608299.1 → XP_038464227.1  protein arginine N-methyltransferase 5 isoform X4

      Conserved Domains (3) summary
      pfam05185
      Location:278 → 447
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 273
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:451 → 618
      PRMT5_C; PRMT5 oligomerization domain

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

      Range
      3371200..3380454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038544176.1 → XP_038400104.1  protein arginine N-methyltransferase 5 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NN99, A0A8C0PPS3, A0A8C0QWZ0, A0A8I3RQT2
      Conserved Domains (3) summary
      pfam05185
      Location:295 → 464
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 290
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:468 → 635
      PRMT5_C; PRMT5 oligomerization domain

    2. XM_038544175.1 → XP_038400103.1  protein arginine N-methyltransferase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NN99
      Conserved Domains (3) summary
      pfam05185
      Location:305 → 474
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 300
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:478 → 645
      PRMT5_C; PRMT5 oligomerization domain

    3. XM_038544179.1 → XP_038400107.1  protein arginine N-methyltransferase 5 isoform X5

      UniProtKB/TrEMBL
      A0A8C0NQU7
      Conserved Domains (3) summary
      pfam05185
      Location:189 → 358
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:1 → 184
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:362 → 529
      PRMT5_C; PRMT5 oligomerization domain

    4. XM_038544177.1 → XP_038400105.1  protein arginine N-methyltransferase 5 isoform X3

      UniProtKB/TrEMBL
      A0A8C0NQU7
      Conserved Domains (3) summary
      pfam05185
      Location:288 → 457
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 283
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:461 → 628
      PRMT5_C; PRMT5 oligomerization domain

    5. XM_038544178.1 → XP_038400106.1  protein arginine N-methyltransferase 5 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NQU7, A0A8C0RV99, A0A8I3MM19
      Conserved Domains (3) summary
      pfam05185
      Location:278 → 447
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 273
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:451 → 618
      PRMT5_C; PRMT5 oligomerization domain

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      3196693..3205933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_537366.7 → XP_537366.2  protein arginine N-methyltransferase 5 isoform X2

      UniProtKB/TrEMBL
      A0A8C0NN99, A0A8C0PPS3, A0A8C0QWZ0, A0A8I3RQT2
      Conserved Domains (3) summary
      pfam05185
      Location:295 → 464
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 290
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:468 → 635
      PRMT5_C; PRMT5 oligomerization domain

    2. XM_022421801.2 → XP_022277509.1  protein arginine N-methyltransferase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NN99
      Conserved Domains (3) summary
      pfam05185
      Location:305 → 474
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:37 → 300
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:478 → 645
      PRMT5_C; PRMT5 oligomerization domain

    3. XM_038583338.1 → XP_038439266.1  protein arginine N-methyltransferase 5 isoform X5

      UniProtKB/TrEMBL
      A0A8C0NQU7
      Conserved Domains (3) summary
      pfam05185
      Location:189 → 358
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:1 → 184
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:362 → 529
      PRMT5_C; PRMT5 oligomerization domain

    4. XM_022421802.2 → XP_022277510.1  protein arginine N-methyltransferase 5 isoform X3

      UniProtKB/TrEMBL
      A0A8C0NQU7
      Conserved Domains (3) summary
      pfam05185
      Location:288 → 457
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 283
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:461 → 628
      PRMT5_C; PRMT5 oligomerization domain

    5. XM_852436.4 → XP_857529.1  protein arginine N-methyltransferase 5 isoform X4

      UniProtKB/TrEMBL
      A0A8C0NQU7, A0A8C0RV99, A0A8I3MM19
      Conserved Domains (3) summary
      pfam05185
      Location:278 → 447
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam17285
      Location:20 → 273
      PRMT5_TIM; PRMT5 TIM barrel domain
      pfam17286
      Location:451 → 618
      PRMT5_C; PRMT5 oligomerization domain
    Nucleotide Protein
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