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    Ldlrad2 low density lipoprotein receptor class A domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502992, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Ldlrad2provided by RGD
    Official Full Name
    low density lipoprotein receptor class A domain containing 2provided by RGD
    Primary source
    RGD:1564888
    See related
    EnsemblRapid:ENSRNOG00000033503 AllianceGenome:RGD:1564888
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564888
    Summary
    Predicted to be integral component of membrane. Orthologous to human LDLRAD2 (low density lipoprotein receptor class A domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 9.7), Heart (RPKM 6.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ldlrad2 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155062172..155070752, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149778795..149788335, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155914517..155922269, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700013G24 gene like Neighboring gene heparan sulfate proteoglycan 2 Neighboring gene interferon induced transmembrane protein 2, pseudogene 3 Neighboring gene ubiquitin specific peptidase 48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    low density lipoprotein receptor class A domain containing 2; low-density lipoprotein receptor class A domain-containing protein 2
    Names
    low density lipoprotein receptor A domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431233.1 → NP_001418162.1  low density lipoprotein receptor class A domain containing 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D4A2E6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      155062172..155070752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_578500.8 → XP_578500.2  low-density lipoprotein receptor class A domain-containing protein 2

      Related
      ENSRNOP00000052800.2, ENSRNOT00000055947.3
      Conserved Domains (2) summary
      cd00112
      Location:183 → 211
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl00049
      Location:119 → 174
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
    Molecular Biology Databases
    Research Materials