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LDLRAD2 low density lipoprotein receptor class A domain containing 2 [ Homo sapiens (human) ]

Gene ID: 401944, updated on 5-Jan-2022

Summary

Official Symbol
LDLRAD2provided by HGNC
Official Full Name
low density lipoprotein receptor class A domain containing 2provided by HGNC
Primary source
HGNC:HGNC:32071
See related
Ensembl:ENSG00000187942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in fat (RPKM 52.2), gall bladder (RPKM 13.0) and 22 other tissues See more
Orthologs
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Genomic context

See LDLRAD2 in Genome Data Viewer
Location:
1p36.12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (21812265..21825225)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (22138758..22151718)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12165 Neighboring gene RAP1 GTPase activating protein Neighboring gene ubiquitin specific peptidase 48 Neighboring gene Sharpr-MPRA regulatory region 6146 Neighboring gene heparan sulfate proteoglycan 2 Neighboring gene Sharpr-MPRA regulatory region 4422 Neighboring gene ribosomal protein L21 pseudogene 29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
low-density lipoprotein receptor class A domain-containing protein 2
Names
low density lipoprotein receptor A domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013693.3NP_001013715.2  low-density lipoprotein receptor class A domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001013715.2

    Status: VALIDATED

    Source sequence(s)
    AL590103
    Consensus CDS
    CCDS30624.1
    UniProtKB/Swiss-Prot
    Q5SZI1
    Related
    ENSP00000340988.2, ENST00000344642.7
    Conserved Domains (2) summary
    cd00112
    Location:176204
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cl00049
    Location:60152
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    21812265..21825225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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