BCL2 BCL2 apoptosis regulator [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: BCL2provided by VGNC
Official Full Name: BCL2 apoptosis regulatorprovided by VGNC
Primary source: VGNC:VGNC:54274
See related: Ensembl:ENSCAFG00845002725
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: BCL-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	1	NC_051805.1 (13595394..13762294)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	1	NC_006583.4 (14699877..14866689)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	1	NC_049222.1 (13811587..13978482)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	1	NC_049261.1 (13633483..13799972)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	1	NC_049742.1 (13562764..13729319)

Chromosome 1 - NC_051805.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Galectin-3 immunolabelling correlates with BCL2 expression in canine cutaneous mast cell tumours.
Title: Galectin-3 immunolabelling correlates with BCL2 expression in canine cutaneous mast cell tumours.
Serum starvation and TdR methods could achieve sufficient synchronization of CHMm cells. Moreover, the expression of p27, p53 and bcl-2 genes was related to cyclical movements and apoptosis.
Title: Serum starvation and thymidine double blocking achieved efficient cell cycle synchronization and altered the expression of p27, p53, bcl-2 in canine breast cancer cells.
Mucosal imbalance of Bcl-2/caspase 3 expression favors T cell resistance to apoptosis which may contribute to T cell accumulation and chronic intestinal inflammation.
Title: Bcl-2/caspase 3 mucosal imbalance favors T cell resistance to apoptosis in dogs with inflammatory bowel disease.
The expression of Bax, Bcl-2, and caspase-3, -8 and -9, was evaluated by evaluating mRNA levels in the peripheral blood, lymph nodes and cerebellum of canine distemper virus (CDV)-infected (CDV+) and uninfected (CDV-) dogs.
Title: Caspase-3/-8/-9, Bax and Bcl-2 expression in the cerebellum, lymph nodes and leukocytes of dogs naturally infected with canine distemper virus.
Malignant proliferation in canine hemangiosarcomas is associated with bcl-2 and survivin expression.
Title: Expression of the anti-apoptotic factors Bcl-2 and survivin in canine vascular tumours.
The aim of this study was to investigate whether downregulation of Bcl-2 expression by small interfering RNA against the canine Bcl-2 gene would enhance the apoptosis and sensitivity of a canine mammary gland tumor cell line to doxorubicin.
Title: The effect of small interfering RNA (siRNA) against the Bcl-2 gene on apoptosis and chemosensitivity in a canine mammary gland tumor cell line.
Inducing QLalpha12 led to degradation of the anti-apoptotic protein Bcl-2 (via the proteasome pathway), increased JNK activity, and up-regulated IkappaBalpha protein levels, a potent stimulator of apoptosis.
Title: Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha.
Bcl-2 phosphorylation by activated p38 MAPK is a key event in the early induction of apoptosis under conditions of cellular stress
Title: Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences.

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General gene information

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Markers

PMC104155P1 (e-PCR)
- UniSTS:270102

Bcl2 (e-PCR), detects polymorphism
- UniSTS:265514

BCL2 (e-PCR)
- UniSTS:498012

UniSTS:461954 (e-PCR)
- UniSTS:461954

Bcl2 (e-PCR), detects polymorphism
- UniSTS:461954

PMC125347P1 (e-PCR)
- UniSTS:270490

PMC137064P1 (e-PCR)
- UniSTS:270815

Bcl2 (e-PCR), detects polymorphism
- UniSTS:266976

PMC150726P1 (e-PCR)
- UniSTS:271073

PMC16825P1 (e-PCR)
- UniSTS:271602

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: apoptosis regulator Bcl-2

Names: B-cell CLL/lymphoma 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002949.1 → NP_001002949.1 apoptosis regulator Bcl-2

See identical proteins and their annotated locations for NP_001002949.1

Status: PROVISIONAL

Source sequence(s)

AB154172

UniProtKB/TrEMBL

A0A8C0RJ94, Q75SV7

Related

ENSCAFP00845003877.1, ENSCAFT00845004846.1

Conserved Domains (3) summary

smart00265
Location:7 → 31

BH4; BH4 Bcl-2 homology region 4

cd06845
Location:94 → 201

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

TIGR00865
Location:1 → 239

bcl-2; apoptosis regulator