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    Aifm3 apoptosis inducing factor, mitochondria associated 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303786, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Aifm3provided by RGD
    Official Full Name
    apoptosis inducing factor, mitochondria associated 3provided by RGD
    Primary source
    RGD:1306028
    See related
    EnsemblRapid:ENSRNOG00000037957 AllianceGenome:RGD:1306028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306028
    Summary
    Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 77.5), Kidney (RPKM 13.7) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    11q23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97009100..97030601, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83504859..83523630, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87364452..87380705)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene THAP domain containing 7 Neighboring gene leucine zipper like post translational regulator 1 Neighboring gene CRK like proto-oncogene, adaptor protein Neighboring gene transfer RNA serine (anticodon UGA) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Apoptosis-inducing factor is involved in gentamicin-induced vestibular hair cell death. Zhang D, et al. ORL J Otorhinolaryngol Relat Spec, 2012. PMID 22085972
    2. Role for apoptosis-inducing factor in the physiological death of cerebellar neurons. Blancas S, et al. Neurochem Int, 2011 Jul. PMID 21447364
    3. Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis. Xie Q, et al. J Biol Chem, 2005 May 20. PMID 15764604
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AIF participates in GM-induced apoptosis of vestibular hair cells.
      Title: Apoptosis-inducing factor is involved in gentamicin-induced vestibular hair cell death.
    2. Apoptosis-inducing factor is involved in apoptotic-like death of cerebellar granule neurons and could be an alternative mechanism of neuronal death during cerebellar development.
      Title: Role for apoptosis-inducing factor in the physiological death of cerebellar neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC109275

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-inducing factor 3
    Names
    apoptosis-inducing factor, mitochondrion-associated 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013977.3 → NP_001013999.2  apoptosis-inducing factor 3

      Status: VALIDATED

      Source sequence(s)
      CB769270, JAXUCZ010000011
      UniProtKB/TrEMBL
      D3ZF03
      Related
      ENSRNOP00000048427.2, ENSRNOT00000040978.6
      Conserved Domains (5) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam00070
      Location:333 → 413
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:194 → 492
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:511 → 561
      Reductase_C; Reductase C-terminal
      cl21454
      Location:195 → 284
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      97009100..97030601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270455.1 → XP_063126525.1  apoptosis-inducing factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A793
      Related
      ENSRNOP00000088997.1, ENSRNOT00000112032.2

    2. XM_039088260.2 → XP_038944188.1  apoptosis-inducing factor 3 isoform X1

      Conserved Domains (3) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:194 → 492
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:511 → 561
      Reductase_C; Reductase C-terminal

    3. XM_063270454.1 → XP_063126524.1  apoptosis-inducing factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A793

    4. XM_039088259.2 → XP_038944187.1  apoptosis-inducing factor 3 isoform X1

      Conserved Domains (3) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:194 → 492
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:511 → 561
      Reductase_C; Reductase C-terminal

    5. XM_008768875.4 → XP_008767097.1  apoptosis-inducing factor 3 isoform X1

      Conserved Domains (3) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:194 → 492
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:511 → 561
      Reductase_C; Reductase C-terminal

    6. XM_063270456.1 → XP_063126526.1  apoptosis-inducing factor 3 isoform X3

    RNA

    1. XR_010055949.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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