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Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 [ Mus musculus (house mouse) ]

Gene ID: 72168, updated on 8-Nov-2022

Summary

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Official Symbol
Aifm3provided by MGI
Official Full Name
apoptosis-inducing factor, mitochondrion-associated 3provided by MGI
Primary source
MGI:MGI:1919418
See related
Ensembl:ENSMUSG00000022763 AllianceGenome:MGI:1919418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aifl; 2810401C16Rik
Summary
Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to act upstream of or within apoptotic process. Located in mitochondrion. Is expressed in heart. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 65.0), cortex adult (RPKM 36.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Aifm3 in Genome Data Viewer
Location:
16; 16 A3
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17307418..17325349)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17489624..17507485)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene synaptosomal-associated protein 29 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog-like Neighboring gene leucine-zipper-like transcriptional regulator, 1 Neighboring gene THAP domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Chinta SJ, et al. Free Radic Biol Med, 2009 Apr 1. PMID 19280713, Free PMC Article
  2. Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Racedo SE, et al. Am J Hum Genet, 2015 Feb 5. PMID 25658046, Free PMC Article
  3. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (17) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptosis-inducing factor 3
Names
apoptosis-inducing factor like
apoptosis-inducing factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291070.1 → NP_001277999.1  apoptosis-inducing factor 3 isoform 1

    See identical proteins and their annotated locations for NP_001277999.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI835101, AK012958, AK158809
    Consensus CDS
    CCDS79430.1
    UniProtKB/Swiss-Prot
    Q3TY86, Q8BWV0
    UniProtKB/TrEMBL
    A0A8C6HKC3
    Related
    ENSMUSP00000111349.2, ENSMUST00000115685.10
    Conserved Domains (3) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:198 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:512 → 562
    Reductase_C; Reductase C-terminal

  2. NM_175178.4 → NP_780387.2  apoptosis-inducing factor 3 isoform 2

    See identical proteins and their annotated locations for NP_780387.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame alternate exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AK158809, BY255255, CD742217
    Consensus CDS
    CCDS28003.1
    UniProtKB/Swiss-Prot
    Q3TY86
    UniProtKB/TrEMBL
    A0A8C6HHJ1
    Related
    ENSMUSP00000023448.7, ENSMUST00000023448.15
    Conserved Domains (5) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam00070
    Location:334 → 414
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:195 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:512 → 562
    Reductase_C; Reductase C-terminal
    cl21454
    Location:196 → 285
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17307418..17325349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522595.4 → XP_006522658.1  apoptosis-inducing factor 3 isoform X7

    See identical proteins and their annotated locations for XP_006522658.1

    Conserved Domains (2) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:195 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  2. XM_036160135.1 → XP_036016028.1  apoptosis-inducing factor 3 isoform X7

    Conserved Domains (2) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:195 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  3. XM_006522590.4 → XP_006522653.1  apoptosis-inducing factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006522653.1

    Conserved Domains (3) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:198 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:512 → 562
    Reductase_C; Reductase C-terminal

  4. XM_006522592.4 → XP_006522655.1  apoptosis-inducing factor 3 isoform X2

    See identical proteins and their annotated locations for XP_006522655.1

    UniProtKB/Swiss-Prot
    Q3TY86, Q8BWV0
    UniProtKB/TrEMBL
    A0A8C6HKC3
    Conserved Domains (3) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:198 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:512 → 562
    Reductase_C; Reductase C-terminal

  5. XM_036160134.1 → XP_036016027.1  apoptosis-inducing factor 3 isoform X6

    Conserved Domains (3) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:195 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:512 → 553
    Reductase_C; Reductase C-terminal

  6. XM_006522594.4 → XP_006522657.1  apoptosis-inducing factor 3 isoform X5

    Conserved Domains (2) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:198 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

  7. XM_006522593.4 → XP_006522656.1  apoptosis-inducing factor 3 isoform X3

    Conserved Domains (3) summary
    cd03478
    Location:70 → 156
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:183 → 478
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:497 → 547
    Reductase_C; Reductase C-terminal

  8. XM_036160133.1 → XP_036016026.1  apoptosis-inducing factor 3 isoform X4

    Conserved Domains (3) summary
    cd03478
    Location:70 → 156
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:180 → 478
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:497 → 547
    Reductase_C; Reductase C-terminal

  9. XM_006522591.4 → XP_006522654.1  apoptosis-inducing factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006522654.1

    Conserved Domains (3) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:198 → 493
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:512 → 562
    Reductase_C; Reductase C-terminal

  10. XM_036160136.1 → XP_036016029.1  apoptosis-inducing factor 3 isoform X8

    Conserved Domains (3) summary
    cd03478
    Location:1 → 81
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:113 → 411
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:430 → 480
    Reductase_C; Reductase C-terminal

RNA

  1. XR_001781867.2 RNA Sequence

  2. XR_004939223.1 RNA Sequence

  3. XR_004939224.1 RNA Sequence

  4. XR_003951834.2 RNA Sequence

  5. XR_004939225.1 RNA Sequence

  6. XR_003951835.2 RNA Sequence

  7. XR_004939228.1 RNA Sequence

  8. XR_003951836.2 RNA Sequence

  9. XR_001781868.2 RNA Sequence

  10. XR_004939226.1 RNA Sequence

  11. XR_004939227.1 RNA Sequence

  12. XR_004939229.1 RNA Sequence

  13. XR_003951837.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TY86.1 GenPept UniProtKB/Swiss-Prot:Q3TY86

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