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    Mideas mitotic deacetylase associated SANT domain protein [ Mus musculus (house mouse) ]

    Gene ID: 238317, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mideasprovided by MGI
    Official Full Name
    mitotic deacetylase associated SANT domain proteinprovided by MGI
    Primary source
    MGI:MGI:2685106
    See related
    Ensembl:ENSMUSG00000042507 AllianceGenome:MGI:2685106
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm260; Elmsan1; 9430029N19Rik; C130039O16Rik
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of histone deacetylase complex and transcription regulator complex. Is expressed in brain; cerebral cortex; and telencephalon ventricular layer. Orthologous to human MIDEAS (mitotic deacetylase associated SANT domain protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen adult (RPKM 12.5), lung adult (RPKM 10.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 39.07 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84195942..84265679, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84149168..84218881, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, light chain 1 Neighboring gene paraneoplastic antigen MA1 Neighboring gene predicted gene, 40476 Neighboring gene VISTA enhancer mm529 Neighboring gene STARR-positive B cell enhancer ABC_E4036 Neighboring gene STARR-positive B cell enhancer ABC_E8492 Neighboring gene STARR-seq mESC enhancer starr_32733 Neighboring gene predicted gene, 31513 Neighboring gene predicted gene, 51953 Neighboring gene predicted gene, 46319 Neighboring gene STARR-seq mESC enhancer starr_32734 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene prostaglandin reductase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Turnbull RE, et al. Nat Commun, 2020 Jun 26. PMID 32591534, Free PMC Article
    2. Homologs of genes expressed in Caenorhabditis elegans GABAergic neurons are also found in the developing mouse forebrain. Hammock EA, et al. Neural Dev, 2010 Dec 1. PMID 21122108, Free PMC Article
    3. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
    4. An Oct4-centered protein interaction network in embryonic stem cells. van den Berg DLC, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362541, Free PMC Article
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitotic deacetylase-associated SANT domain protein
    Names
    ELM2 and Myb/SANT-like domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163501.1 → NP_001156973.1  mitotic deacetylase-associated SANT domain protein

      See identical proteins and their annotated locations for NP_001156973.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC125071, AC159649
      Consensus CDS
      CCDS49109.1
      UniProtKB/TrEMBL
      A0A1Y7VP67, E9Q2I4
      Related
      ENSMUSP00000048120.7, ENSMUST00000046266.13
      Conserved Domains (3) summary
      PTZ00121
      Location:887 → 1068
      PTZ00121; MAEBL; Provisional
      pfam01448
      Location:715 → 770
      ELM2; ELM2 domain
      cl21498
      Location:824 → 868
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. NM_001163502.1 → NP_001156974.1  mitotic deacetylase-associated SANT domain protein

      See identical proteins and their annotated locations for NP_001156974.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC125071
      Consensus CDS
      CCDS49109.1
      UniProtKB/TrEMBL
      A0A1Y7VP67, E9Q2I4
      Related
      ENSMUSP00000105923.2, ENSMUST00000110294.2
      Conserved Domains (3) summary
      PTZ00121
      Location:887 → 1068
      PTZ00121; MAEBL; Provisional
      pfam01448
      Location:715 → 770
      ELM2; ELM2 domain
      cl21498
      Location:824 → 868
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84195942..84265679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157404.1 → XP_036013297.1  mitotic deacetylase-associated SANT domain protein isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VP67
      Conserved Domains (2) summary
      pfam01448
      Location:715 → 770
      ELM2; ELM2 domain
      cl21498
      Location:824 → 868
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein Strain
    Heading Accession and Version

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