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MIDEAS mitotic deacetylase associated SANT domain protein [ Homo sapiens (human) ]

Gene ID: 91748, updated on 4-Dec-2022

Summary

Official Symbol
MIDEASprovided by HGNC
Official Full Name
mitotic deacetylase associated SANT domain proteinprovided by HGNC
Primary source
HGNC:HGNC:19853
See related
Ensembl:ENSG00000156030 AllianceGenome:HGNC:19853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LSR68; ELMSAN1; C14orf43; c14_5541; C14orf117
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen (RPKM 10.0), ovary (RPKM 7.3) and 25 other tissues See more
Orthologs
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Genomic context

See MIDEAS in Genome Data Viewer
Location:
14q24.3
Exon count:
16
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (73715122..73790285, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (67922658..67994755, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (74181825..74253911, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene dynein axonemal light chain 1 Neighboring gene RNA, U6 small nuclear 240, pseudogene Neighboring gene PNMA family member 1 Neighboring gene uncharacterized LOC124903345 Neighboring gene microRNA 4505 Neighboring gene MIDEAS antisense RNA 1 Neighboring gene small nucleolar RNA U13 Neighboring gene long intergenic non-protein coding RNA 2274

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00335, FLJ98645

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitotic deacetylase-associated SANT domain protein
Names
ELM2 and Myb/SANT domain containing 1
ELM2 and Myb/SANT-like domain containing 1
ELM2 and SANT domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001043318.3NP_001036783.1  mitotic deacetylase-associated SANT domain protein isoform 1

    See identical proteins and their annotated locations for NP_001036783.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC006146, AK127785, BC006511, BC009202, BC015668, DN999792
    Consensus CDS
    CCDS9819.1
    UniProtKB/Swiss-Prot
    Q6PJG2, Q6ZS23
    UniProtKB/TrEMBL
    A0A024R689
    Related
    ENSP00000377634.2, ENST00000394071.6
    Conserved Domains (3) summary
    smart00717
    Location:837876
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:723778
    ELM2; ELM2 domain
    cl21498
    Location:832876
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  2. NM_001367710.1NP_001354639.1  mitotic deacetylase-associated SANT domain protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longer isoform (2). Variants 3 and 4 both encode the same isoform (2).
    Source sequence(s)
    AC006146
    Consensus CDS
    CCDS91901.1
    UniProtKB/TrEMBL
    A0A1C7CYX1
    Related
    ENSP00000407767.2, ENST00000423556.7
    Conserved Domains (2) summary
    pfam01448
    Location:723778
    ELM2; ELM2 domain
    cl21498
    Location:832876
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  3. NM_001394972.1NP_001381901.1  mitotic deacetylase-associated SANT domain protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 3, encodes the longer isoform (2).
    Source sequence(s)
    AC005520, AC006146
    Consensus CDS
    CCDS91901.1
    UniProtKB/TrEMBL
    A0A1C7CYX1
    Conserved Domains (2) summary
    pfam01448
    Location:723778
    ELM2; ELM2 domain
    cl21498
    Location:832876
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  4. NM_194278.4NP_919254.2  mitotic deacetylase-associated SANT domain protein isoform 1

    See identical proteins and their annotated locations for NP_919254.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (1).
    Source sequence(s)
    AC006146
    Consensus CDS
    CCDS9819.1
    UniProtKB/Swiss-Prot
    Q6PJG2, Q6ZS23
    UniProtKB/TrEMBL
    A0A024R689
    Related
    ENSP00000286523.5, ENST00000286523.9
    Conserved Domains (3) summary
    smart00717
    Location:837876
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam01448
    Location:723778
    ELM2; ELM2 domain
    cl21498
    Location:832876
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    73715122..73790285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268206.1XP_005268263.1  mitotic deacetylase-associated SANT domain protein isoform X1

    See identical proteins and their annotated locations for XP_005268263.1

    UniProtKB/TrEMBL
    A0A1C7CYX1
    Conserved Domains (2) summary
    pfam01448
    Location:723778
    ELM2; ELM2 domain
    cl21498
    Location:832876
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
  2. XM_047431913.1XP_047287869.1  mitotic deacetylase-associated SANT domain protein isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYX1
  3. XM_047431914.1XP_047287870.1  mitotic deacetylase-associated SANT domain protein isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYX1
  4. XM_047431915.1XP_047287871.1  mitotic deacetylase-associated SANT domain protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    67922658..67994755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)