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    PAK2 p21 (RAC1) activated kinase 2 [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009535, updated on 8-Mar-2024

    Summary

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    Gene symbol
    PAK2
    Gene description
    p21 (RAC1) activated kinase 2
    See related
    Ensembl:ENSOCUG00000008224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    PAKI; Pak3
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 14 NC_067387.1 (93023713..93138606, complement)

    Chromosome 14 - NC_067387.1Genomic Context describing neighboring genes Neighboring gene NCBP2 antisense 2 (head to head) Neighboring gene nuclear cap binding protein subunit 2 Neighboring gene SUMO specific peptidase 5 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class X Neighboring gene centrosomal protein 19 Neighboring gene negative regulator of reactive oxygen species

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_067387.1 Chromosome 14 Reference UM_NZW_1.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and sequencing of the cytostatic G protein-activated protein kinase PAK I. Jakobi R, et al. J Biol Chem, 1996 Mar 15. PMID 8626411

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 2
    Names
    PAK-2
    gamma-PAK
    p21 protein (Cdc42/Rac)-activated kinase 2
    p21-activated kinase 2
    p21-activated kinase I
    p21-activated protein kinase I
    NP_001076225.1
    XP_017202139.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082756.1 → NP_001076225.1  serine/threonine-protein kinase PAK 2

      See identical proteins and their annotated locations for NP_001076225.1

      Status: PROVISIONAL

      Source sequence(s)
      U46915
      UniProtKB/Swiss-Prot
      Q29502
      Related
      ENSOCUP00000007111.2, ENSOCUT00000008227.2
      Conserved Domains (3) summary
      cd06655
      Location:229 → 524
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:249 → 500
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:73 → 128
      PBD; P21-Rho-binding domain

    RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UM_NZW_1.0 Primary Assembly

    Genomic

    1. NC_067387.1 Reference UM_NZW_1.0 Primary Assembly

      Range
      93023713..93138606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017346650.2 → XP_017202139.1  serine/threonine-protein kinase PAK 2 isoform X1

      UniProtKB/Swiss-Prot
      Q29502
      Conserved Domains (3) summary
      cd06655
      Location:229 → 524
      STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
      smart00220
      Location:249 → 500
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam00786
      Location:73 → 128
      PBD; P21-Rho-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q29502.1 GenPept UniProtKB/Swiss-Prot:Q29502

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