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Pak2 p21 (RAC1) activated kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 224105, updated on 8-Feb-2024

Summary

Official Symbol
Pak2provided by MGI
Official Full Name
p21 (RAC1) activated kinase 2provided by MGI
Primary source
MGI:MGI:1339984
See related
Ensembl:ENSMUSG00000022781 AllianceGenome:MGI:1339984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAK-2; mKIAA4182; D16Ertd269e; 5330420P17Rik; A130002K10Rik
Summary
Enables protein serine/threonine kinase activity. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Located in postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including brain and corpus striatum. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 14.2), bladder adult (RPKM 12.7) and 28 other tissues See more
Orthologs
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Genomic context

See Pak2 in Genome Data Viewer
Location:
16 B2; 16 22.4 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (31835108..31898160, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32016290..32079342, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene SUMO/sentrin specific peptidase 5 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene high mobility group box 1, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_40638 Neighboring gene predicted gene, 26419 Neighboring gene STARR-positive B cell enhancer ABC_E7439 Neighboring gene STARR-positive B cell enhancer ABC_E4164 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:32107830-32107983 Neighboring gene centrosomal protein 19

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA4182

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adherens junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dendritic spine development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein localization to cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
PubMed 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase PAK 2
Names
gamma-PAK
p21 protein (Cdc42/Rac)-activated kinase 2
p21-activated kinase 2
NP_796300.1
XP_006522135.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177326.3NP_796300.1  serine/threonine-protein kinase PAK 2

    See identical proteins and their annotated locations for NP_796300.1

    Status: VALIDATED

    Source sequence(s)
    AK037275, AK220528
    Consensus CDS
    CCDS28112.1
    UniProtKB/Swiss-Prot
    Q8CIN4
    Related
    ENSMUSP00000023467.8, ENSMUST00000023467.9
    Conserved Domains (2) summary
    cd06655
    Location:229524
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:73127
    PBD; P21-Rho-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    31835108..31898160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522072.5XP_006522135.1  serine/threonine-protein kinase PAK 2 isoform X1

    See identical proteins and their annotated locations for XP_006522135.1

    UniProtKB/Swiss-Prot
    Q8CIN4
    Conserved Domains (2) summary
    cd06655
    Location:229524
    STKc_PAK2; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2
    pfam00786
    Location:73127
    PBD; P21-Rho-binding domain